Maximum daily dose

Drug Initial Daily Dose Target or Maximum Daily Dose Monitoring... 

Antibiotic Pediatric Dose (mg/kg per day) Adult Maximum Daily Dose Interval (Hours)... 

Buspirone should be initiated at a dose of 7.5 mg twice daily and titrated in 5 mg/day increments (every 2-3 days) to a usual target dose of 20 to 30 mg/day.41 The maximum daily dose is considered to be 60 mg/day. 

Decongestants such as OTC pseudoephedrine are sympathomimetic agents that constrict capacitance vessels in the nasal turbinates.17 Decongestants effectively reduce nasal congestion and to some extent rhinorrhea associated with AR.8,12 The recommended dose of pseudoephedrine is 30 to 60 mg every 4 to 6 hours for a maximum daily dose of 240 mg.15 Systemic adverse effects such as irritability, dizziness, headache, tremor, tachycardia, and insomnia can occur. Additionally, use is associated with increased blood pressure and intraocular pressure and urinary obstruction.8,12... 

Drug Dosage Forms Usual Daily Dose Maximum Daily Dose... 

Diuretic therapy should be initiated with single morning doses of spironolactone, 100 mg, and furosemide, 40 mg, with a goal of 0.5-kg maximum daily weight loss. The dose of each can be increased together, maintaining the 100 40 mg ratio, to a maximum daily dose of 400 mg spironolactone and 160 mg furosemide. 

Oral tablets 25,50, or 100 mg at onset can repeat after 2 hours if needed Optimal dose is 50-100 mg maximum daily dose is 200 mg... 

Daypro , a nonsteroidal antiinflammatory agent, has a maximum daily dose requirement of 26 mg/kg/day. What is the maximum number of Daypro 600 mg tablets that can be given to a 127-lb patient ... 

Maximum daily dose (g/day) Reporting threshold (%) Identification threshold Qualification threshold... 

When used for detoxification, phenobarbital is given in equal doses four times a day. The maximum daily dose of phenobarbital is 600 mg, but much lower doses are usually sufficient. The phenobarbital dose is lowered (i.e., tapered) by about 20% per day. If the patient is too drowsy, then a dose should be skipped. If breakthrough withdrawal symptoms continue to occur, then the pace of the detoxification should be slowed. Before using phenobarbital, liver function tests should be obtained. All barbiturates depend greatly on the liver to be metabolized. Alcoholics with cirrhosis or other forms of liver impairment may have difficulty clearing phenobarbital. Phenobarbital should not be used in patients with poor liver function. In addition, the barbiturates can worsen a medical condition known as porphyria and should be avoided in those with this disorder. Phenobarbital, as noted, is seldom used today for alcohol detoxification. 

ICH Q3 A(R) [8] provides a clear guidance for the control of the organic impurities. Table 1.1 describes the hmits or thresholds for the reporting, identification, and qualification of the impurities based on the maximum daily dose of the drug substance administered per day. 

Threshold Maximum daily dose of drug product Threshold limit based on total daily intake (TDI)... 

Crystalline nicotinic acid - Usual daily dose is 1.5 to 3 g (maximum daily dose 4.5 g). 

Chiidren Safety and efficacy of metformin IR for the treatment of type 2 diabetes have been established in children 10 to 16 years of age who demonstrated a similar response in glycemic control to that seen in adults. Adverse effects were similar to those described in adults. A maximum daily dose of 2,000 mg is recommended. Safety and efficacy of metformin ER in children have not been established. 

Heart failure As adjunctive therapy with diuretics and digitalis, the recommended starting dose is 2.5 mg twice daily. The usual therapeutic dosing range for the treatment of heart failure is 2.5 to 20 mg/day given in 2 divided doses. The maximum daily dose is 40 mg. 

Serum sodium less than 130 mEq/L or with serum creatinine greater than 1.6 mg/dL Initiate at 2.5 mg/day under close medical supervision. The dose may be increased to 2.5 mg twice daily, then 5 mg twice daily and higher as needed, usually at intervals of 4 days or more. The maximum daily dose is 40 mg. 

Heart failure-The recommended starting dose is 40 mg twice daily. Up-titrate to 80 and 160 mg twice daily to the highest dose, as tolerated. Consider reducing the dose of concomitant diuretics. The maximum daily dose in clinical trials was 320 mg in divided doses. Concomitant use with an ACE inhibitor and a beta-blocker is not recommended. 

Oral-0.5 to 2 mg/day, given as a single dose. If diuretic response is not adequate, give a second or third dose at 4- to 5-hour intervals, up to a maximum daily dose of 10 mg. An intermittent dose schedule, given on alternate days or for 3 to 4 days with rest periods of 1 to 2 days in between, is the safest and most effective method for the continued control of edema. In patients with hepatic failure, keep the dose to a minimum, and if necessary, increase the dose carefully. 

Do not exceed the maximum daily dose of 8 mg with an intermittent flow nebulization system or 14 mg with a continuous flow nebulization system. 

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