Calcium disodium

RN 62-33-9 MF C, H,2CaN2Na20s MW 374.27 EINECS 200-529-9 calcium disodium salt hydrate... [Pg.730]

Dosages of EDTA are delivered as the calcium disodium salt, Na2[Ca(EDTA)]. The calcium complex prevents EDTA from extracting iron from the blood. Unlike iron, heavy metal ions such as preferentially... [Pg.1328]

Urinary lead levels have also been used to measure current exposure (Robinson 1974) but they are of questionable value as biomarkers of exposure because of the relatively low and fluctuating lead levels that are excreted in the urine (ACGIH 1986 Ibels and Pollock 1986 Jensen 1984). In contrast, the determination of urinary lead following a single injection of the chelating agent, calcium disodium EDTA, which mobilizes extracellular lead and produces increased urinary excretion of lead, is presumed to be indicative of an elevated body burden of lead (Cory-Slechta et al. 1987 Ibels and Pollock 1986 Janin et al. 1985). Children whose PbB levels are 45 pg/dL should not receive a provocative chelation... [Pg.313]

Cory-Slechta DA, Weiss B, Cox C. 1987. Mobilization and redistribution of lead over the course of calcium disodium ethylenediamine tetraacetate chelation therapy. J Pharmacol Exp Ther 243 804-813. [Pg.505]

A common form of EDTA used as a preservative is calcium disodium EDTA (CaNa2EDTA). What metals will this form of the sequestrant scavenge effectively The dissolution of the solid will yield calcium ions, sodium ions, and the EDTA anion. Any metal more effectively complexed than calcium will be readily scavenged, including all ions listed in Table 9.1 except silver (Ag+) and magnesium (Mg2+). (In the absence of the calcium counterion, as in the case of the acid form of EDTA, chelation of calcium in the body can occur. In fact, EDTA administered orally is an FDA-approved treatment for calcium deposits in the bloodstream that lead to cardiovascular disease.) Citric acid (Fig. 9.3.3) is another sequestrant of metal ions in foodstuffs. [Pg.121]

In mammals, phenobarbital and phenytoin increase serum ceruloplasmin concentrations (Aaseth and Norseth 1986). Chronic copper poisoning in sheep is exacerbated when diets contain heliotrope plants (Heliotropium sp., Echium spp., Senecio sp.). Aggravated effects of the heliotrope plants include reduced survival and a twofold to threefold increase in liver and kidney copper concentrations when compared to control animals fed copper without heliotropes (Howell et al. 1991). Rats given acutely toxic doses of 2,3,7,8-tetrachlorodibenzo-para-dioxin had elevated concentrations of copper in liver and kidney because of impaired biliary excretion of copper (Elsenhans et al. 1991). Morphine increases copper concentrations in the central nervous system of rats, and dithiocarbam-ates inhibit biliary excretion (Aaseth and Norseth 1986). In human patients, urinary excretion of copper is increased after treatment with D-penicillamine, calcium disodium EDTA, or calcium trisodium diethylenetriamine penta acetic acid (Flora 1991). [Pg.139]

Alkali aluminate (5-calcium disilicate monosulfate), phase in Portland cement clinker, 5 472t Alkali aluminate (8-calcium disodium trialuminate), phase in Portland cement clinker, 5 472t Alkali belite, phase in Portland cement clinker, 5 472t Alkali blue toners, 14 318 Alkali borate glasses, 12 572, 573, 584 Alkali catalysed pad-dry-bake procedure, 9 485... [Pg.29]

Calcium cyanamid process, for ammonia synthesis, 11 114, 115 Calcium cyanide, 8 194-197 Calcium cyanide diammoniate, 8 195 Calcium dichromate, molecular formula, properties, and uses, 6 561t 5-Calcium disilicate monosulfate, phase in Portland cement clinker, 5 472t 5-Calcium disilicate monocarbonate, phase in Portland cement clinker, 5 472t Calcium disilicide, 4 530 8-Calcium disodium trialuminate, phase in Portland cement clinker, 5 472t Calcium doping, 23 842-844 Calcium P-alumina, 2 406t Calcium ethylenediaminetetraacetate, 7 596t... [Pg.133]

E 385 Calcium disodium ethylene diamine tetra-acetate (Calcium disodium EDTA)... [Pg.36]

Ethylenediaminetetraacetic acid, calcium disodium salt hydrate [23411-34-9] Fenpropidin [67306-00-7] Fenpropimorph [67564-91-4] Flupropadin 81613-59-41 Haloperidol [52-86-8] 1605D EV7700000, USP EU1575000, USP... [Pg.1056]

Edetate calcium disodium Calcium Disodium Versenate) Lead... [Pg.369]

Dimercaprol, edetate calcium disodium, D-Penicillamine, succimer... [Pg.372]

Lead Calcium disodium edetate Forms inactive complete with metal... [Pg.66]

Several chelators can effectively lower the child s blood lead level. These include dimercaprol, ede-tate calcium disodium (CaNazEDTA) and suc-cimer. Protocols are available for using the chelators depending upon the severity of symptoms. [Pg.72]

Poisoning, lead (mild) IM Initially, 4 mg/kg, then 3 mg/kg q4h for 2-7 days in combination with edetate calcium disodium injection at different injection sites. Poisoning, lead (severe) IM 4 mg/kg q4h for 2-7 days in combination with edetate calcium disodium injection at different injection sites. [Pg.378]

Brand Name(s) Calcium Disodium Versenate Chemical Class Chelating agent... [Pg.414]

Specific iron binding chelating agent like desferrioxamine mesylate (5-10 g in 100 ml isotonic saline) or calcium diethylene triamine pentaacetate (DTP A) 35-40 mg/kg or calcium disodium acetate (35-40 mg/kg). [Pg.249]

Salt and chelate formation with edetate (ethylenediaminetetraacetate, EDTA). A In a solution of calcium disodium salt of EDTA, the sodium and hydrogen ions are chemically and biologically available. B In solutions of calcium disodium edetate, calcium is bound by coordinate-covalent bonds with nitrogens as well as by the usual ionic bonds. C In the lead-edetate chelate, lead is incorporated into five heterocyclic rings. [Pg.1238]

Dimercaprol is FDA-approved as single-agent treatment of acute poisoning by arsenic and inorganic mercury and for the treatment of severe lead poisoning when used in conjunction with edetate calcium disodium (EDTA see below). Although studies of its metabolism in humans are limited, intramuscularly administered dimercaprol appears to be readily absorbed, metabolized, and excreted by the kidney within 4-8 hours. Animal models indicate that it may also undergo biliary excretion, but the role of this excretory route in humans and other details of its biotransformation are uncertain. [Pg.1240]

Ethylenediaminetetraacetic acid (Figure 57-2) is an efficient chelator of many divalent and trivalent metals in vitro. To prevent potentially life-threatening depletion of calcium, the drug should be administered only as the calcium disodium salt. [Pg.1241]

Edetate calcium disodium is indicated chiefly for the chelation of lead, but it may also have usefulness in poisoning by zinc, manganese, and certain heavy radionuclides. In spite of repeated claims in the alternative medicine literature, EDTA has no demonstrated usefulness in the treatment of atherosclerotic cardiovascular disease. [Pg.1241]

Parenteral 100 mg/mL for IM injection Edetate calcium [calcium EDTA] (Calcium Disodium Versenate)... [Pg.1244]

Vancocin HC1 for oral solution contains vancomycin hydrochloride equivalent to 10 g (6.7 mmol) or 1 g (0.67 mmol) vancomycin. Calcium disodium edetate, equivalent... [Pg.205]

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