Calcium edetate

Lead poisoning (withoutencephalopathy) IM/IV 1-1.5 g/m dailyfor 3-5 days (if blood lead concentration > 100 mc dl, calcium edetate usually given with dimercaprol.) Allow at least 2-4 days, up to 2-3 wk between courses of therapy Patients should not be given more than 2 courses of therapy... 

It is indicated in metallic intoxication due to arsenic, mercury, gold, bismuth, lead, nickel, thallium and antimony in conjunction with sodium calcium edetate for lead poisoning. It is also useful in hepatolenticular degeneration (Wilson s disease). It is contraindicated in iron and cadmium poisoning. 

Sodium calcium edetate, D-penicillamine Dimercaprol, D-penicillamine, BAL Ethanol... 

The treatment of lead poisoning involves the use of chelating agents to remove the lead from the soft tissues of the body. Thus, agents such as sodium calcium edetate may be used. 

T rimethobenzamide Phenethicillin Potassium 416.4 Piperazine Calcium Edetate... 

Dicobalt edetate. Cobalt forms stable, nontoxic complexes with cyanide. It is toxic (especially if the wrong diagnosis is made and no cyanide is present), causing hypertension, tachycardia and chest pain consequent cobalt poisoning is treated by giving sodium calcium edetate and i.v. glucose. 

Calcium edetate can cause mild transient hypercalcemia (4) and hypercalciuria (5). 

Sodium calcium edetate can cause the same adverse effects as the disodium salt, with the exception of hypocalcemia. 

Intravenous administration of disodium edetate can cause renal insufficiency and acute tubular necrosis (2). In children with subclinical lead poisoning, the administration of sodium calcium edetate and dimercaprol together was associated with mild and transient biochemical evidence of renal damage in 13% of patients, whereas another 3% had acute renal insufficiency (19). 

Calcium Edetate Figure 2-8. Chelation reactions in metal poisoning. 

In general, piperazine and a good munber of its salts e.g., adipate, calcium edetate, citrate, phosphate and tartrate— have been employed profusely in therapeutic treatment of roundworm and pinworm infections. Piperazine itself is a representative example of this class of compoimds ... 

Many drugs cause diuresis by influencing the secretory and resorptive properties of the kidneys which were discussed in Section 3.1. Several drugs are known which act directly on the haematopoietic system (e.g. phenindione, warfarin, sodium calcium edetate, amethopterin), on fibrous tissues (e.g. salicylates, prednisolone, cortisone), and on tumours. 

Calcium EDTA 11.28), injected as its sodium salt, sodium calcium edetate, is a most effective remedy for lead poisoning (Bessman, Rubin and Leikin, 1954). Sodium edetate (the same substance minus the calcium) was used in an attempt to decalcify stenosed valves in the heart even though it also caused a fall in blood calcium, the patients were none the worse after long courses of injections, e.g. 3 g (as a 0.5% solution) every 24 hours for 5 days a week, and 3 weeks per month (Seven, 1960). Sodium edetate has been used successfully to overcome digitalis-induced cardiac arrhythmia by restoring K /Ca - balance (Szekely and Wynne, 1963). 

Sodium calcium edetate. See Calcium disodium EDTA... 

Slow i.v. infusion of sodium calcium edetate enhances urinary excretion of lead... 

Di-Na monO Ca salt [62-33-9]. Sodium calcium edetate, BAN, INN. Edetate calcium disodium, USAN. Edathamil calcium disodium. Calcium disodium versenate. Mosatil. Antallin. Ledclair. Other proprietary names Powerful chelating agent used for treatment of lead poisoning. Powder. Forms a tetrahydrate. 

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