Blood pressure, effect

Blood pressure effects were recorded from cannulized femoral arteries in anesthetized rats after subcutaneous injection. Maximal falls in blood pressure occurred within 30 minutes of injection. Small responses were seen at the 5mg/kg level, but as the dose was increased marked hypotension occurred. 

Bretylium is also an adrenergic neuron blocker which lowers blood pressure effectively, but it is also associated with unpleasant adverse reactions. 

Blood pressure effect. Fruit juice, administered intravenously hy infusion to dogs at a dose of 3 mL/minute for 100 minutes, was active. Initial effect was a decrease in hlood pressure . Oil, administered to male weanling rats at a dose of 10% of diet for 5 weeks, produced significantly higher hlood pressure than other groups. Systolic hlood pressure was found related to the dietary intakes of saturated and unsaturated fatty acids. Prenatal exposure of the rats to a maternal low-protein diet abolished the hypertensive effect of the coconut oil dieH . Butyryl cholinesterase activity. Oil was administered to rats at different doses with or without clofibrate for 15 days. The hypolipidemic action of clofibrate was not... 

No blood pressure effects, including orthostatic hypotension Potential disadvantages... 

Engleman EA, McBride WJ, Li TK, Lumeng L, Murphy JM (2003) Ethanol drinking experience attenuates (—)sulpiride-induced increases in extracellular dopamine levels in the nucleus ac-cumbens of alcohol-preferring (P) rats. Alcohol Clin Exp Res 27 424-31 Ennis C, Kemp JD, Cox B (1981) Characterisation of inhibitory 5-hydroxytryptamine receptors that modulate dopamine release in the striatum. J Neurochem 36 1515-20 Ensinger H, Majewski H, Hedler L, Starke K (1985) Neuronal and postjunctional components in the blood pressure effects of dopamine and bromocriptine in rabbits. J Pharmacol Exp Ther 234 681-90... 

In contrast, SK F 82526 is about ten times as potent as dopamine, and has about 1.6 times the maximal effect of dopamine as a renal vasodilator in anesthetized dogs. It causes a slight tachycardia, and at higher doses moderately decreases blood pressure. SK F 87516 is about three times as potent as, and shows about 80% of the maximal effect of dopamine as a renal vasodilator. However, it produces negligible blood pressure effects and exhibits a potent and profound bradycardiac effect suggesting that it may have presynaptic dopamine agonist activ-... 

No chronic-duration oral MRL was established for barium, despite the observation of a NOAEL and a LOAEL for blood pressure effects in a chronic rat study by Perry et al. (1983,1985,1989), because the resulting MRL would have been approximately 19-50-fold lower than the estimated daily intake of barium from air, water, and dietary sources combined. 

The multiple difficulties encountered in the quantification of ACE inhibitor blood pressure effects have importantly contributed to a general improvement in the antihypertensive drug development process leading up to registration by health authorities (234, 235). Definition of the dose-range that is effective in blood pressure lowering has become more and more precise with time (236). It became obvious that a placebo-controlled investigation of the effect of ACE inhibitors on... 

In addition to NF-kB, Ang II-induced vascular inflammation is critically regulated by the ETS family of transcription factors such as Ets-1. Systemic administration of Ang II to Ets-/- mice has been associated with a marked reduction in medial hypertrophy and recmitment of inflammatory cells into the vascular wall compared to that in wild-type mice, independent of the blood pressure effect (Zhan et al. 2005). 

Hydrochlorides of dibenzazonines 14b, 106,107, and 108 have been tested by Pecherer and Brossi (29) for analgesic and anti-inflammatory activity, antiappetite and blood pressure effects, and activity against a series of infections. The alkaloid protostephanine (3) exerts a moderately strong and persistent hypotensive effect. Most of the other compounds show some central nervous activity. Independent studies have also found CNS activity for compounds 107, 109, and 110, all of which behave as hypotensive agents (30). 

Kronig MH, Roose SP, Walsh BT, Woodring S, Glassman AH. Blood pressure effects of phenelzine. J Clin Psychopharmacol 1983 3(5) 307-10. 

SAFETY PROFILE Poison by ingestion, subcutaneous, intravenous, and intraperitoneal routes. Experimental reproductive effects. Chronic exposure causes central nervous system damage and blood-pressure effects. When heated to decomposition it emits toxic NOx. See other amphetamine entries. 

Why does this sort of diet work so well One theory is that a diet rich in fruits, vegetables, and nonfat and low-fat dairy foods might work as a natural diuretic, much as do certain drugs that are prescribed for lowering blood pressure. These medications have been used to fight hypertension for decades. It s still unknown whether the blood pressure effects gotten from the diet are the result of a specific food or foods or a combination of all of them. The diet is rich in potassium and calcium, both of which help the body to eliminate sodium in the urine. Yet apparently there s more to it than that because supplementation with those two minerals doesn t yield as strong a result. 

Most of the blood pressure effect occurs quickly (hours, days) but there is often a modest further decrease over several weeks. 

Two studies that compared the interaction of celecoxib with ACE inhibitors found no difference in blood pressure effects compared to placebo [58, 59]. In one study (n=359), the blood pressure (systohc and diastolic) effects of celecoxib 200 mg BID and nabumetone 1 g BID were found to be similar to placebo, but significantly different from ibuprofen 800 mg IID [58]. In the second study (n=178), the effects of celecoxib 400 mg daily and placebo on 24-hour blood pressure in hypertensive patients controlled on hsinopiil 10-40 mg daily was evaluated [59]. No difference between groups was observed in 24-hour ambulatory SBP. The difference between groups in 24-hour diastolic BP was only 1.4 mm Hg. The change from baseline in 24-hour blood pressure (1.8 mm Hg/1.4mm Hg) is less than what has been the effect of NSAIDs on the SBP (defined as an increase >20 mm Hg with an absolute value of >140 mm Hg) reported for traditional NSAIDs in ACE inhibitor-treated patients. On the other hand, co-ad-ministration of rofecoxib 25 mg daily with benazepril 10-40 mg for 4 weeks in patients with mild to moderate... 

Replacement of the amino by a hydrazine moiety preserved some of the sympathomimetic effects of the parent amines such as psychomotor stimulation and rise in the dog blood pressure. The hydrazine isosteres, on the other hand, were essentially devoid of the direct CNS stimulant and potent blood pressure effects of the sympathomimetic amines (19, 22, 52). 

Alkaloid Effect on blood pressure Effect on heart rate General effects Fatal dose mg.ptg.)... 

Triflupromazine, possessing potent sedative properties, is contraindicated in patients with disorders accompanied by coma, brain damage, CNS depression, circulatory collapse, or cerebrovascular disease (additive CNS depression and adverse blood pressure effects) and in patients taking adrenergic-blocking agents or spinal or epidural anesthetics (excessive respiratory, cardiac, and CNS depression). 

Blood pressure effects are unpredictable. The action of these drugs increases circulating levels of norepinephrine and epinephrine, which tend to raise pressure. At the same time, they stimulate the inhibition of central vasoregulatory centers that tend to decrease sympathetic activity. 

CHRONIC HEALTH RISKS weight loss weakness anemia neurological symptoms blood pressure effects affects hearing threshold and growth in children interference with vitamin D metabolism severe depression of sperm counts decrease function of the prostate impaired mental development decease IQ scores in children spontaneous abortion low birth weight. 

CHRONIC HEALTH RISKS human blood pressure effects human teratogenic effects development abnormalities of the cardiovascular system may alter genetic material target organs central nervous system, cardiovascular system, lungs, gastrointestinal tract, reproductive system. 

---