High blood pressure, controlling, effectiveness

The most common adverse effect seen with ESA is increased blood pressure, which can occur in up to 23% of patients.31 Antihypertensive agents may be required to control blood pressure in patients receiving ESAs. Caution should be used when initiating an ESA in patients with very high blood pressures (greater than 180/100 mm Hg). If blood pressures are refractory to antihypertensive agents, ESAs may need to be withheld. 

The p-blockers are quite popular antihypertensive drugs. They are well tolerated, and serious side effects are seldom observed. When used alone over several weeks, p-blockers produce a signihcant reduction in blood pressure in approximately 30% of patients with mild to moderate hypertension. Thus, -blockers can be employed as a first step in the management of high blood pressure. However, they are often used in conjunction with a diuretic when therapy with a single agent is not satisfactory. The combination of a p-blocker, thiazide diuretic, and vasodilator provides signihcant control of moderate to severe hypertension in approximately 80% of patients. 

The control of water content has an effect on the blood pressure. Therefore drugs which can affect the balance of water or ions within the nephron can have a clinical use in the treatment of hypertension (high blood pressure). These pharmaceuticals are known as diuretics because their use results in an increased excretion of water. Since they all have the same general effect, diuresis, they represent a pharmacological class of compounds. Some may be related to each other on a structural level and be further associated as members of a structural class as well. 

Emergency treatment depends on the immediate toxic effects of BZP and TFMPP. High blood pressure, abnormal heart rate or rhythm, seizures or convulsions, fever, and abnormal movements all have specific treatments and may require hospitalization for intravenous medications and general supportive care. Coma or decreased level of consciousness, respiratory depression, difficulty breathing, and severe allergic reaction may require treatment in an intensive care unit and assisted respiration. If a user experiences any untoward effects, or if someone inadvertently takes a much larger dose of medicinal piperazines than prescribed, it is prudent to contact a doctor, emergency medical services, or poison control. 

The most common withdrawal symptoms are emotional in nature. However, the same principle—that withdrawal reactions are the opposite of the primary drug effect—also applies to physical symptoms of withdrawal. A drug that controls blood pressure is likely to result in a reaction with excessively high blood pressure during withdrawal, and a drug that controls seizures can result in seizures during withdrawal. 

Not much was known about how to prevent heart attacks and strokes back in those days, but high blood pressure was already considered a major culprit. Unfortunately, doctors knew even less about how to control hypertension other than with the first antihypertensive drugs. And, as is still the case today, those drugs had a long list of side effects, not the least of which was the nuisance my father experienced with the need for frequent urination and fatigue. Many, if not most, men had greatly diminished sexual drive, too. 

There s a far less expensive tool I can recommend that helps you to become effective with relaxed breathing. It s called RES-PeRATE and is a device that runs you through breathing exercises and has been clinically proven to be beneficial in controlling both stress and hypertension. You can learn more about RESPeRATE and can order it online at www.high-blood-pressure-help.com. 

We ve heard a lot about how cutting back on salt and sodium is essential to blood pressure control. But take that advice with the proverbial grain of salt Yes, very high salt and sodium intake can raise blood pressure. And extreme restriction can lower it. But this approach isn t practical, and many men and women are not sensitive to the effects of salt and sodium. By all means, we should practice moderation. But most of the sodium in the modern diet comes not from the salt shaker or the salt on the rim of a margarita glass but, rather, from processed and canned foods and from fast food. 

About 84% of the patients in the Reduction of Endpoints in NIDDM with the Angiotensin II Antagonist Losartan Study (RENAAL) required diuretic therapy to effect blood pressure control (31). Although not specifically reported, a similarly high proportion of patients were likely to have required diuretic therapy to reach the target blood pressure in the Irbesartan Diabetic Nephropathy Trial (IDNT) (32). These studies remind us once again of the importance of targeting volume control in order to reduce blood pressure in patients with chronic renal insufficiency. 

The dosage for all these drugs when used alone was too high to achieve adequate blood pressure control hence it was a blessing when chlorothiazide and its many derivatives appeared. These natriuretic drugs by virtue of acting in a variety of ways allowed most of the antihypertensive drugs to be much more efficient and hence smaller doses were required. This reduced the intolerable side effects in many cases. 

---