Dopamine modulators

Waszezak, B.L., and Walters, J.R. Dopamine modulation of the effects of y-aminobutyric acid on substantia nigra pars reticulata neurons. Science 220 218-221, 1983. 

Aripiprazole was formulated in the early 1980s to function as a potential dopamine modulator, with both antagonist and agonist activity at the D2 receptor. It is the first D2 partial agonist available for the treatment of schizophrenia and is sometimes referred to as a third-generation antipsychotic. This novel mechanism is... 

CE Crosson, RW Beuerman, SD Klyce. (1984). Dopamine modulation of active ion transport in rabbit corneal epithelium. Invest Ophthalmol Vis Sci 25 1240-1245. 

Lavin A., Grace A. A. (1998). Dopamine modulates the responsivity of mediodorsal thalamic cells recorded in vitro. J. Neurosci. 18(24), 10566-78. 

It is widely accepted that Parkinson s disease primarily results from degeneration of pigmented neurons in the substantia nigra (Gibb 1998). This causes a loss of nigrostriatal projections and lack of dopamine modulation in the striatum. In addition to loss of neurons, many of the remaining neurons contain Lewy bodies. 

We can develop two very plausible and distinct hypotheses to integrate Hofmann s LSD story with sleep and dream research (on the one hand) and with schizophrenia research (on the other). Serotonin modulation provides the link to dreaming and dopamine modulation provides the link to schizophrenia. 

Azdad K, Piet R, Poulain DA, Oliet SH (2003) Dopamine D4 receptor-mediated presynaptic inhibition of GABAergic transmission in the rat supraoptic nucleus. J Neurophysiol 90 559-65 Baimoukhametova DV, Hewitt SA, Sank CA, Bains JS (2004) Dopamine modulates use-dependent plasticity of inhibitory synapses. J Neurosci 24 5162-71 Bakker RA (2004) Histamine H3-receptor isoforms. Inflamm Res 53 509-16 Bakker RA, Lozada AF, van Marie A, Shenton FC, Drutel G, Karlstedt K, Hoffmann M, Lintunen M, Yamamoto Y, van Rijn RM, Chazot PL, Panula P, Leurs R (2006) Discovery of naturally occurring splice variants of the rat histamine H3 receptor that act as dominant-negative isoforms. Mol Pharmacol 69 1194-1206... 

Davila NG, Blakemore LJ, Trombley PQ (2003) Dopamine modulates synaptic transmission between rat olfactory bulb neurons in culture. J Neurophysiol 90 395 104 Delgado A, Sierra A, Querejeta E, Valdiosera RF, Aceves J (2000) Inhibitory control of the GABAergic transmission in the rat neostriatum by D2 dopamine receptors. Neuroscience 95 1043-8... 

Meyer DK, Krauss J (1983) Dopamine modulates cholecystokinin release in neostriatum. Nature 301 338-40... 

Kreitzer AC, Malenka RC (2005) Dopamine modulation of state-dependent endocannabinoid release and long-term depression in the striatum. J Neurosci 25(45) 10537—45 Kreitzer AC, Regehr WG (2001) Retrograde inhibition of presynaptic calcium influx by endogenous cannabinoids at excitatory synapses onto purkinje cells. Neuron 29 717-27 Kreitzer AC, Carter AG, Regehr WG (2002) Inhibition of interneuron firing extends the spread of endocannabinoid signaling in the cerebellum. Neuron 34 787-96... 

Seamans JK, Gorelova N, Durstewitz D, Yang CR. 2001a. Bidirectional dopamine modulation of GABAergic inhibition in prefrontal cortical pyramidal neurons. J Neurosci 21 3628-3638. 

Seamans JK, Yang CR. 2004. The principal features and mechanisms of dopamine modulation in the prefrontal cortex. Prog Neurobiol 74 1-58. 

Bamford NS, Robinson S, Palmiter RD, Joyce JA, Moore C, et al. 2004. Dopamine modulates release from corticostria-tal terminals. J Neurosci 24 9541-9552. 

Ohtani N, Goto T, Waeber C, Bhide PG. 2003. Dopamine modulates cell cycle in the lateral ganglionic eminence. J... 

We found that a GSH deficit reversed the direction of DA modulation of NMDA responses (Steullet et al., 2008). In control neurons, DA enhanced NMDA responses. But in neurons with a BSO-induced GSH deficit, DA decreased NMDA responses via activation of D2-type receptors. This decrease disappeared when normal GSH levels were restored by GSH-ethyl ester, a membrane-permeable GSH analog. The difference in dopamine modulation of NMDA responses in control neurons and in neurons with a GSH deficit was mostly explained by a differential modulation of L-type calcium channels. DA enhanced the function of these channels in control neurons, but decreased it in BSO-treated neurons. The redox-sensitive ryanodine receptors (RyRs), which were enhanced in BSO-treated neurons, played an essential role in altering DA signaling in neurons with a GSH deficit. These data suggest that enhancement of the function of RyRs in neurons with low GSH levels favors D2-type receptor-mediated and calcium-dependent pathways, causing a change in DA modulation of L-type calcium channels and ultimately in DA modulation of NMDA responses. 

Steullet P, Lavoie S, Kraftsik R, Guidi R, Gysin R, et al. 2008. A glutathione deficit alters dopamine modulation of L-type calcium channels via D2 and ryanodine receptors in neurons. Free Radical Biol Med 44 1042-1054. 

DOPAMINE MODULATION OF STRIATAL OUTPUT THROUGH THE DIRECT AND INDIRECT PATHWAYS... 

Gao W-J, Wang Y, Goldman-Rakic PS (2003) Dopamine modulation of perisomatic and peridendritic inhibition in prefrontal cortex. J Neurosci 23 1622-1630. 

Greif GJ, Lin YJ, Liu JC, Freedman JE (1995) Dopamine-modulated potassium channels on rat striatal neurons specific activation and cellular expression. J Neurosci /5 4533 4544. 

Levine MS, Cepeda C (1998) Dopamine modulation of responses mediated by excitatory amino acids in the neostriatum. Adv Pharmacol 42 724-729. 

Lin YJ, Chen X, Freedman JE (1998) U-37883A potently inhibits dopamine-modulated K+ channels on rat striatal neurons. Eur J Pharmacol 552 335-341. 

Davila NG, Blakemore LJ, Trombley PQ. 2003. Dopamine modulates synaptic transmission between rat olfectory bulb neurons in culture. J Neurophysiol 90 395-404. 

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