5- Hydroxytryptamine receptor

HT3 receptor. 5-Hydroxytryptamine receptor a receptor for serotonin (a neurotransmitter), which activates a variety of second messenger signaling systems and through them indirectly regulates the function of ion channels. 

Samanin, R and Grignaschi, G (1996) Role of 5-hydroxytryptamine receptor subtypes in satiety and animal models of eating disorders. In Drug Receptor Subtypes and Ingestive Behaviour (Eds Cooper, SJ and Clifton, PG), Academic Press, London, pp. 39-58. 

Cheng, H.C., and Long, J.P. Effects of d- and /-amphetamine on 5-hydroxytryptamine receptors. Arch Int Pharmacodyn Ther 204 124-131, 1973. 

FDA, Combined Use of 5-Hydroxytryptamine Receptor Agonists (Triptans), Selective Serotonin Reuptake Inhibitors (SSRIs) or Selective Serotonin/Norepinephrine Reuptake Inhibitors (SNRIs) May Result in Life-Threatening Serotonin Syndrome , FDA Public Health Advisory (2006) http //www.fda.gov/Cder/Drug/advisory/ S SRI S S200607.htm... 

Ko FN, Yu SM, Su MJ, Wu YC, Teng CM. Pharmacological activity of (-)-discreta-mine, a novel vascular alpha-adrenoceptor and 5-hydroxytryptamine receptor antagonist, isolated from Fissistigma glaucescens. BrJ Pharmacol. 1993 110 882-888. 

N-methyl-actinodaphnine possesses 5-hydroxytryptamine receptor blocking activity and a selective antagonist of cq-adrenoceptors, selective for the a1B. than for the a1A-adrenoceptor subtype (14). What are the activities of N-methyl-actinodaphnine and other aporphines of Illigera and Hernandia species against topoisomerase ... 

Leccese, A.R, Lyness, W.H. The effects of putative 5-hydroxytryptamine receptor active agents on D-amphetamine self-administration in controls and rats with 5,7-dihydroxytryptamine median forebrain bundle lesions. Brain Res. 303 153, 1984. 

Blier P, Steinberg S, Chaput Y, de Montigny C. (1989). Electrophysiological assessment of putative antagonists of 5-hydroxytryptamine receptors a single-cell study in the rat dorsal raphe nucleus. Can J Physiol Pharmacol. 67(2) 98-105. 

Dennis J. McKenna, David B. Repke, Leland Lo, and Stephen J. Peroutka. "Differential interactions of indolealkylamines with 5-hydroxytryptamine receptor subtypes." Neuropharmacology 29 (1990) 193-98. 

A life-threatening condition, when selective serotonin reuptake inhibitors (SSRIs) and 5-hydroxytryptamine receptor agonists (triptans) are used together. However, many other drugs have been implicated (see below). Signs and symptoms of serotonin syndrome include the following ... 

A series of indole oxadiazoles, such as (249), have been shown to be potent antagonists of the 5-hydroxytryptamine receptors <91JMC140>. 

HTid receptors—5-hydroxytryptamine receptors (a subclass of serotonergic receptors)... 

D. N. Middlemiss, M. Hibert, J. R. Fozard (1986). Drugs acting at central 5-hydroxytryptamine receptors. Awwm. Rep. Med. Chem. 21 41-50. 

It is an alkaloid obtained from an African plant Yohimbehe. Chemically it is an indolealkylamine related to reserpine. It has selective blocking property with short duration of action and also blocks 5-hydroxytryptamine receptors. It produces increase in heart rate and blood pressure due to increase in noradrenaline release. It does not have any role in clinical practice. 

Engleman EA, McBride WJ, Li TK, Lumeng L, Murphy JM (2003) Ethanol drinking experience attenuates (—)sulpiride-induced increases in extracellular dopamine levels in the nucleus ac-cumbens of alcohol-preferring (P) rats. Alcohol Clin Exp Res 27 424-31 Ennis C, Kemp JD, Cox B (1981) Characterisation of inhibitory 5-hydroxytryptamine receptors that modulate dopamine release in the striatum. J Neurochem 36 1515-20 Ensinger H, Majewski H, Hedler L, Starke K (1985) Neuronal and postjunctional components in the blood pressure effects of dopamine and bromocriptine in rabbits. J Pharmacol Exp Ther 234 681-90... 

Baumgarten, H. G. and Goethert, M. (Eds) Serotoninergic neurons and 5-hydroxytryptamine receptors in the CNS. Handbook of Experimental Pharmacology, Vol. 129. Berlin Springer-Verlag, 1997. 

Key Words Serotonin 5-hydroxytryptamine receptor sequence database. 

Lovenberg TW, Erlander MG, Baron BM, et al. Molecular cloning and functional expression of 5-HTlE-like rat and human 5-hydroxytryptamine receptor genes. Proc Natl Acad Sci USA 1993 90 2184-2188. 

Arvidsson LE, Hacksell U, Johansson AM, et al. 8-Hydroxy-2-(alkylamino) tetralins and related compounds as central 5-hydroxytryptamine receptor agonists. J Med Chem 1984 27 45-51. 

Maswood N, Caldarola-Pastuszka M, Uphouse L. Functional integration among 5-hydroxytryptamine receptor families in the control of female rat sexual behavior. Brain Res 1998 802 98-103. 

Shenker A, Maayani S, Weinstein H, Green JP. Pharmacological characterization of two 5-hydroxytryptamine receptors coupled to adenylate cyclase in guinea pig hippocampal membranes. Mol Pharmacol 1987 31 357-367. 

Newman-Tancredi A, Wootton R, Strange PG. High-level stable expression of recombinant 5-HT1A 5-hydroxytryptamine receptors in Chinese hamster ovary cells. Biochem J 1992 285(Pt 3) 933-938. 

Saudou F, Hen R. 5-Hydroxytryptamine receptor subtypes in vertebrates and invertebrates. Neurochem Int 1994 25 503-532. 

Toumois C, Mutel V, Manivet P, Launay JM, Kellermann O. Cross-talk between 5-hydroxytryptamine receptors in a serotonergic cell line. Involvement of arachi-donic acid metabolism. J Biol Chem 1998 273 17,498—17,503. 

Parekh AB, Foguet M, Lubbert H, Stuhmer W. Ca2+ oscillations and Ca2+ influx in Xenopus oocytes expressing a novel 5-hydroxytryptamine receptor. J Physiol 1993 469 653-671. 

Dumuis A, Bouhelal R, Sebben M, Cory R, Bockaert J. A nonclassical 5-hydroxytryptamine receptor positively coupled with adenylate cyclase in the central nervous system. Mol Pharmacol 1988 34 880-887. 

Schoeffter P, Waeber C. 5-Hydroxytryptamine receptors with a 5-HT6 receptorlike profile stimulating adenylyl cyclase activity in pig caudate membranes. Naunyn Schmiedebergs Arch Pharmacol 1994 350 356-360. 

Mork A, Geisler A. 5-Hydroxytryptamine receptor agonists influence calcium-stimulated adenylate cyclase activity in the cerebral cortex and hippocampus of the rat. Eur J Pharmacol 1990 175 237-244. 

Blier P, Lista A de Montigny C. Differential properties of pre- and postsynaptic 5-hydroxytryptamine receptors in the dorsal raphe and hippocampus II.elfect of pertussis and cholera toxins. J Pharmacol Exp Ther 1993 265 16-23. 

Chaput Y, de Montigny C. Effects of the 5-hydroxytryptamine receptor antagonist BMY 7378, on 5-hydroxytryptamine neurotransmission electrophysiological studies in the rat central nervous system. J Pharmacol Exp Ther 1988 246 359-370. 

Huidobro-Toro JP, Harris RA. Brain lipids that induce sleep are novel modulators of 5-hydroxytryptamine receptors. Proc Natl Acad Sci USA 1996 93 8078-8082. 

Thomas EA, Carson MJ, Neal MJ, Sutcliffe JG. Unique allosteric regulation of 5-hydroxytryptamine receptor-mediated signal transduction by oleamide. Proc Natl Acad Sci USA 1997 94 14,115-14,119. 

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