Automation Testing Procedures

The use of the surface ultrasonic waves seems to be convenient for these purposes. However, this method has not found wide practical application. Peculiarities of excitation, propagation and registration of surface waves created before these time great difficulties for their application in automatic systems of duality testing. It is connected with the fact that the surface waves are weakened by soil on the surface itself In addition, the methods of testing by the surface waves do not yield to automation due to the difficulties of creation of the acoustic contact. In particular, a flow of contact liquid out of the zone of an acoustic line, presence of immersion liquid, availability of chink interval leads to the adsorption and reflection of waves on tlie front meniscus of a contact layer. The liquid for the acoustic contact must be located only in the places of contact, otherwise the influence on the amplitude will be uncontrolled. This phenomenon distorts the results of testing procedure. 

Hub, L. and T. Kupr, "Heat Balance Calorimetry and Automation of the Testing Procedure," in Proceedings of the Runaway Chemical Reaction Hazard Symposium, IBC, London, England (1987). 

Direct injection of blood serum (102) or sample extracts with little or no cleanup (53) is possible, which makes HPLC procedures comparable in speed with other rapid tests With increased use of solid-phase absorption in cleanup, automation of procedures is feasible TLC is also a useful and inexpensive technique and quantitative TLC methods have been described (30,63) The following chapter describes practical application of various procedures in a drug residue monitoring program ... 

The test procedures described above (see Basic Protocols 1 and 2) have recently been simplified by utilizing advanced techniques such as ultrasonic and infrared spectroscopy. The purchase of one of these advanced analytical instruments is recommended for emulsion manufacturers that frequently conduct emulsion stability tests and require automated analysis of a large number of samples. 

The instructions embedded in computer program(s) either provide information on what the operators are supposed to do, or information on how the equipment or processes are intended to function. For example, for manufacturing operations, the batch production and control records may provide procedures, controls, instructions, specifications, and precautions to be followed when using computer systems. These programs may also contain control data for product formulation, batch size, yields, and automated in-process sampling/testing procedures. 

Preferably, tests and the documentation of results should be done automatically, always using the same set of test files. In this way, users are encouraged to perform the tests more frequently, and user specific errors are eliminated. In some cases, vendors provide test files and automated test routines for verification of a computer system s performance in the user s laboratory. Needless to say, the correct functioning of this software should also be verified. If such software is not available, the execution of the tests and the verification of actual results with prerecorded results can be done manually. Successful execution of such a procedure ensures that ... 

The flow rate of the dissolution medium through the cell must be specified for each product. The USP recommends a flow rate between 4 and 16ml/min with an allowance of 5%. Manual operation and sampling for this type of test can be tedious and the system can be automated to control the pump, heat exchanger and test procedure, and deliver samples to a fraction collector. The system can be programmed to switch between different media at predetermined time points to allow pH changes during the test. 

Varga D, Johannes T, Jainta S, et al. An automated scoring procedure for the micronucleus test by image analysis. Mutagenesis. 2004 19(5) 391-397. 

Functional high-throughput multifunctional screening of chemosensitive properties of conductive polymers was described recently.44 The authors developed a minimal test procedure consisting of two concentration pulses of an analyte at the same concentration and a sequence of concentration pulses at increased concentrations. Automated analysis of the materials responses has given the following information ... 

Testing procedure. The automated instruments (e.g., Quantachrome NOVA 1000 or Micrometries Gemini 2360) are used for rapid surface determination. The physical adsorption of nitrogen or other inert gas should be conducted at a pressure which is within the range of linearity. 

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