Antigen delivery systems

Thus, liposomes—with or without adjuvants—have a potential as antigen delivery systems. No clear insights exist on how to prepare liposome-based vaccines with optimum immunological properties by rationale instead of by trial and error. Therefore, much basic work is needed to unravel the mechanisms involved. [Pg.307]

E. C. (1988b). Incorporation of the major outer membrane protein of Neisseria gonorrhoeae in saponin-Upid complexes (Iscoms) Chemical analysis, some structural features, and comparison of their immunogenicity with three other antigen delivery systems, Inf. Immun., 56, 432-438. [Pg.324]

O Hagan DT (1998) Recent advances in immunological adjuvants the development of particulate antigen delivery systems. Exp Opin Invest Drugs 7 349-359... [Pg.60]

Stomi T, Kundig TM, Senti G et al (2005) Immunity in response to particulate antigen-delivery systems. Adv Drug Deliv Rev 57 333-355... [Pg.60]

Ohagan, D.T. et al., Biodegradable Microparticles as Controlled Release Antigen Delivery Systems, Immunology. 73, 239, 1991. [Pg.13]

Mestecky, J., Michalek, S. M., Moldoveanu, Z., and Russell, M. W. (1997). Routes of immunization and antigen delivery systems for optimal mucosal immune responses in humans. Behring Inst. Mitt. 98, 33-43. [Pg.152]

Bungener DT, Huckriede A, Wilschut J. Virosomes as an antigen delivery system. J Liposome Res 2000 10 329-338. [Pg.340]

It is of particular clinical relevance to test the effects of mucosal allergen application in already sensitized organisms. The obvious advantage of the use of so-called hypoallergenic molecules lies in their risk-free application. Thus, the practical consequences from such experimental studies could include the development of low-risk mucosal vaccines based on the induction of tolerance - with or without the use of certain mucosal antigen delivery systems. [Pg.20]

OHagan, D.T., D. Rafferty, S. Wharton, and L. Ilium. 1993. Intravaginal immunization in sheep using a bioadhesive microsphere antigen delivery system. Vaccine 11 660. [Pg.436]

However, in general, only low levels of antibodies have been induced by intravaginal immunizations and the antibodies generated have been predominantly localized in the genital tract, even in the presence of potent antigen delivery systems. [Pg.295]

Singh, M. O Hagan, D. The preparation and characterization of polymeric antigen delivery systems for oral administration. Adv. Drug. Delivery Rev. 1998, 34, 285-304. Wurzburg, O.B. Starch in the food industry. 1972, 1, 361-395. [Pg.3482]

Live Attenuated Organisms. Live attenuated bacteria and viruses have been used not only as vaccines but also as a delivery system that elicits humoral, mucosal, and cellular immune responses against exogenous antigens. Since the success with live attenuated oral vaccines against tuberculosis and polio more than 3 decades ago, a number of live attenuated microorganisms have been used as antigen-delivery systems. Live vaccines are relatively easy and cheap to manufacture, because they do not require purification of... [Pg.3919]

Altken R, Hirst TR (1995) Bacterial toxins os novel antigen delivery systems. In Livestock Prod. Sd. 42 163-172. [Pg.12]

Moser C, Metcalfe IC, Viret JF (2003) Virosomal adjuvanted antigen delivery systems. Expert Rev Vaccines 2 189-196... [Pg.27]

Vangala A, Bramwell VW, McNeil S, Christensen D, Agger EM, Perrie Y (2007) Comparison of vesicle based antigen delivery systems for delivery of hepatitis B surface antigen. J Contr Release 119 102-110... [Pg.76]

Kersten G, Hirschberg H (2004) Antigen delivery systems. Expert Rev Vaccines 3 453 62... [Pg.174]

The choice of the phospholipid is dependent on the actual needs of the antigen delivery system. Cationic lipid with a combination of pH-sensitive lipid can be used for DNA-based vaccines delivery or intracellular cytosolic delivery of protein molecules. They may also be used in combination vaccines or in combination with other adjuvants like MPL-A (monophosphoryl lipid A), and cytokines (IL-2, IL-4, IFN-gamma). [Pg.187]

Poly-DL-lactide-co-glycolide microspheres can be used as a controlled-release antigen delivery system - parenteral or oral. [Pg.31]

O Hagan DT, Rahman D, McGee JP, et al. Biodegradable microparticles as controlled release antigen delivery systems. Immunology 1989 73 239-242. [Pg.397]

Based on the promising data obtained using cationic peptides as adjuvant in the sense of antigen delivery systems in the context of vaccines, the question arose as to whether these systems could also be used in combination with other adjuvants. As in earlier experiments cationic peptides were used to transport DNA molecules into cells, it was clear that poly-L-arginine should be tested in combination with oli-godeoxynucleotides containing CpG-motifs (CpG-ODN), which were described to be immunostimulatory substances on their own, and to analyze the immunostimulatory effect of the combined adjuvants. [Pg.1437]

Engineered PHA beads were utilized in high-affinity bio-separation [112-114], enzyme immobilization [115], protein production [116], diagnostics [117], and as an antigen delivery system [118] which is currently being commercialized [98, 69]. Poly [(R)-3-hydroxyalkanoates] (PHAs) biopolymers can be stored by bacteria, and are currently receiving much attention because of their potential as renewable and biodegradable plastics. The best known representatives are poly (hydroxybutyrate) and its copolymers with hydroxyvalerate, which have been commercialized under the trademark Biopol . [Pg.308]

Yuba, E., Harada, A., Sakanishi, Y., Watarai, S., Kono, K. A liposome-based antigen delivery system using pH-sensitive fusogenic polymers for cancer immunotherapy. Biomaterials 34, 3042-3052 (2013)... [Pg.195]

Bhowmick, S., Mazumdar, T., Sinha, R., Ali, N. Comparison of liposome based antigen delivery systems for protection against Leishmania donovani. J. Control. Release 141, 199-207 (2010)... [Pg.195]

Lima, K.M. and Rodrigues Junior, J.M. (1999) Poly-DL-lactide-co-glycolide microspheres as a controlled release antigen delivery system. Braz. J. Med. Biol. Res., 32 (2), 171-180. [Pg.23]

P. Li, Z. Luo, P. Liu, N. Gao, Y. Zhang, H. Pan, L. Liu, C. Wang, L. Cai, Y. Ma, Bioreduc-ible alginate-poly (ethylenimine) nanogels as an antigen-delivery system robustly enhance vaccine-elicited humoral and cellular immune responses. Journal of Controlled Release 168 (2013) 271-279. [Pg.310]

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