Alginate-g-poly

Poly(A, A dimethylacrylamide) (PDMAM) is being used in many fields due to its remarkable properties such as water solubility and biocompatibility. Homo- and copolymers of DMAM have been applied in various fields such as oil recovery and slow release of dmg. Alginate-g-poly(A,A-dimethylacrylamide) (AG-g-PDMAM) was synthesized in order to increase the properties of alginate like sweUability, metal ion uptake and flocculation thereby increasing its potential applications [41]. 

Yadav, M., Sand, A., Behari, K. Synthesis and characterization of graft copolymer (alginate-g-poly(N, N-dimethylacrylamide). Chin. J. Polym. Sci. 28, 673-683 (2010)... 

Oxidised sodium alginate-g-poly(2-dimethylamino)ethyl methacyrlate... 

Alginate-g-poly(methacrylamide) Sodium alginate-g-poly(sodium acrylate)... 

Kolya H, Pal S, Pandey A, Tripathy T. Preparation of gold nanoparticles by a novel biodegradable graft copolymer sodium alginate-g-poly (N, N-dimethylacrylamide-co-acrylic acid) with anti micro bacterial application. Eur Polym J. 2015 66 139-48. 

U.S. Toti, M.Y. Kariduraganavar, K.S. Soppimath, T.M. Aminabhavi, Sorption, diffusion and pervaporation separation of water/acetic acid mixtures through the blend membranes of sodium alginate and guar gum-g-poly(acrylamide), J. Appl. Polym. Sci. 83 (2002) 259-272. 

Na-alginate is natural polysaccharide extracted from seaweeds, with a large availability in nature. Chemically, alginate composed of block polymers namely polyguluronate [poly-G], poly-mannuromate [poly-M] and their copolymer in random sequence [8, 72]. 

Many natural hydrogels are known to be constituents of the extracellular matrix, mucin, glycocalix and so on. Jelly is a well-known example of the use of hydrogels in food. Hydrogels can be obtained from many hydrophilic polymers, either natural (e.g. cellulose, dextran, alginate, hyaltuonic acid, chitosan, pectin) or synthetic (e.g. poly(vinyl alcohol) (PVA), PEG, poly(vinyl pyrrolidone) (PVP), PHEMA, polyacrylamides). 

Wang Q, Zhang JP, Wang AQ (2009) Preparation and characterization of a novel pH-sensitive chitosan-g-poly (acrylic acid)/attapulgite/sodium alginate composite hydrogel bead for controlled release of diclofenac sodium. Carbohydr Polym 78 731-737... 

Microspheres and nanoparticles often consist of biocompatible polymers and belong either to the soluble or the particle type carriers. Besides the aforementioned HPMA polymeric backbone, carriers have also been prepared using dextrans, ficoll, sepharose or poly-L-lysine as the main carrier body. More recently alginate nanoparticles have been described for the targeting of antisense oligonucleotides [28]. As with other polymeric carrier systems, the backbone can be modified with e.g. sugar molecules or antibody fragments to introduce cellular specificity. 

Research on nasal powder drug delivery has employed polymers such as starch, dextrans, polyacrylic acid derivatives (e.g., carbopol, polycarbophil), cellulose derivatives (microcrystalline cellulose, semicrystalline cellulose, hydroxypropylmethyl cellulose, hydroxypropyl cellulose, carboxymethyl cellulose), chitosan, sodium alginate, hyaluronans, and polyanhydrides such as poly(methyl vinyl ether-co-maleic anhydride) (PVM/MA). Many of these polymers have already been used as excipients in pharmaceutical formulations and are often referred to as first-generation bioadhesives [38-45], In nasal dry powder a single bioadhesive polymer or a... 

Milella, E. Barra, G. Ramires, P. A. Leo, G. Aversa, R Romito, A., Poly(L-lactide)acid/ alginate composite membranes for guided tissue regeneration.. /. Biomed. Mater. Res. 2001, 57, 248-257... 

Macromolecular properties of alginates are highly dependent on G/M ratio and sequential distribution of G and M residues within homopolymeric blocks. Poly-guluronate blocks are stiffer than polymannuronate and alternating blocks, which in turn are more soluble at low pH [6]. 

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