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Alkaloid pyrrolizidine

Steroidal Alkaloids and Steroidal Glycoalkaloids Norditerpenoid Alkaloids Pyrrolizidine Alkaloids Indolizidine and Polyhydroxy Alkaloids Tropane Alkaloids Glycosides... [Pg.19]

L-ornithine Ornithine-derived alkaloids True alkaloids Pyrrolidine alkaloids Tropane alkaloids Pyrrolizidine alkaloids... [Pg.63]

Keywords alkaloid biosynthesis alkaloid genes nicotine tropane alkaloids pyrrolizidine alkaloids benzylisoquinoline alkaloids monoterpene indole alkaloids ergot alkaloids acridone alkaloids purine alkaloids taxol betalains... [Pg.20]

PYRROLIDINE ALKALOIDS PYRROLIZIDINE ALKALOIDS TROPANE ALKALOIDS... [Pg.229]

Pinidine and Coniine Nicotiana Alkaloids yV-Methylpelletierine Lycopodium Alkaloids Lyduraceae Alkaloids Pyrrolizidine Group Tropane and Pyrrolidine Alkaloids Quinoline and Acridme Alkaloids Benzodiazepine Alkaloids Tylophora Alkaloids Cactus Alkaloids Ephedrine... [Pg.520]

As a result of these studies we have isolated bioactive compounds belonging to several chemical classes (sesquiterpenes, diterpenes, lignans, diterpenoid alkaloids, pyrrolizidine alkaloids) with selective modes of action and low toxicity. The structure-activity relationships of these compounds have also been established. [Pg.849]

Pyrrolizidine alkaloids Pyrrolizidine Acetyl-lycopsamine Acetyl-intermedine Europine Homospermidine llamine Indicine-N-oxide Meteloidine Retronecine... [Pg.9]

Retronecine (A), which is a simple pyrrolizidine alkaloid, commonly occurs in nature. The formation of the pyrrolizidine structure is presented in Figure 2.35. Retronecine and its P, the senecionine, necine, heliotrine, indicine-A-oxide, malaxine, monocrotaline and absulin, are typical repre-sentatives of this group of alkaloids. Pyrrolizidine alkaloids... [Pg.144]

Distribution of Pyrrolizidine Alkaloids Pyrrolizidine Alkaloids in Animals Pyrrolizidine Alkaloids and Parasitic Plants ITie Role of Pyrrolizidine Alkaloids in Livestock Poisoning... [Pg.546]

If a molecule contains several asymmetric C atoms, then the diastereomers show diastereotopic shifts. Clionasterol (28a) and sitosterol (28b) for example, are two steroids that differ only in the absolute configuration at one carbon atom, C-24 Differing shifts of C nuclei close to this asymmetric C atom in 28a and b identify the two diastereomers including the absolute configuration of C-24 in both. The absolute configurations of carboxylic acids in pyrrolizidine ester alkaloids are also reflected in diastereotopic H and C shifts which is used in solving problem 54. [Pg.55]

Ill spite of their importance, basicity constants rarely figure in descriptions of alkaloids. Figures for a series of alkaloids and related substances were published by Kolthoff in 1925 and have been extensively used. Recently a few more have been added by Schoorl, and Adams and Mahan have provided figures for the whole group of necines, the amino-alcohols resulting from the hydrolysis of the pyrrolizidine group of alkaloids. ... [Pg.821]

The combination of positive and negative charges within the same molecule causes a more complicated situation, which obviously has not been well-defined to date. A quite large number of pyrrolizidine alkaloids are related to Otonecine (8) (Scheme 3). Spectroscopic investigations show that these alkaloids exist in the nonionized form in CDCI3, and in the zwitterionic form in D2O (00JNP857, 71TL3421). The dipolar structure is the result of an intramolecular interaction between a nucleophilic and an electrophilic center. [Pg.70]

Sinnlarly, f-i- -casuralme, a pentahydroxy pyrrolizidine alkaloid, is prepared by a tandem [4-i-3 /[3-i-3 cycloadchdon involving nitroalkene, chiral vinyl ether, and vinyl silane This process creates five of the six stereocenters present in this potent glycosidase inhibitor fScheme 8 35 ... [Pg.282]

Hudlicky and coworkers also reported a related 2-pyrroline formation from viny-laziridines [81], which are extremely useful for the synthesis of pyrrolizidine alkaloids such as the protected (+)-trihydroxyheliotridane 210 (Scheme 2.51). Since the pyrolysis of either diastereomer of 208 furnished the cyclized product 209 as a... [Pg.60]

Figure 10.31 Synthetic route to oxygenated pyrrolizidine alkaloids, and an aza-C-disaccharide as glycosidase inhibitors. Figure 10.31 Synthetic route to oxygenated pyrrolizidine alkaloids, and an aza-C-disaccharide as glycosidase inhibitors.
Hartmann T, Ober D (2000) Biosynthesis and Metabolism of Pyrrolizidine Alkaloids in Plants and Specialized Insect Herbivores. 209. 207-243 Haseley SR, Kamerling JP, Vliegenthart JFG (2002) Unravelling Carbohydrate Interactions with Biosensors Using Surface Plasmon Resonance (SPR) Detection. 218 93-114... [Pg.233]

Note It is reported that the use of chlorobenzene as solvent is essential when the reagent is to be used to detect aromatic amines [1]. In the case of steroids, penicillins, diuretics and alkaloids the reaction should be accelerated and intensified by spraying afterwards with dimethylsulfoxide (DMSO) or dimethylformamide (DMF), indeed this step makes it possible to detect some substances when this would not otherwise be possible [5,9-11] this latter treatment can, like heating, cause color changes [5,9]. Penicillins and diuretics only exhibit weak reactions if not treated afterwards with DMF [10, 11]. Steroids alone also yield colored derivatives with DMSO [9]. Tlreatment afterwards with diluted sulfuric acid (c = 2 mol/L) also leads to an improvement in detection sensitivity in the case of a range of alkaloids. In the case of pyrrolizidine alkaloids it is possible to use o-chloranil as an alternative detection reagent however, in this case it is recommended that the plate be treated afterwards with a solution of 2 g 4-(dimethyl-amino)-benzaldehyde and 2 ml boron trifluoride etherate in 100 ml anhydrous ethanol because otherwise the colors initially produced with o-chloranil rapidly fade [12]. [Pg.103]

Among the many recent applications to natural products, syntheses of pyrrolizidine and indolizidine alkaloids that take advantage of the 1,3-dipolar cycloaddition methodology have been reviewed [8]. The regio- and stereochemistry [9] as well as synthetic appHcations [10] of nitrile oxide cycloadditions have also been discussed. [Pg.2]

The utility of lOOC reactions in the synthesis of fused rings containing a bridgehead N atom such as pyrrolizidines, indolizidines, and quinolizidines which occur widely in a number of alkaloids has been demonstrated [64]. Substrates 242 a-d, that possess properly positioned aldoxime and alkene functions, were prepared from proline or pipecolinic acid 240 (Eq. 27). Esterification of 240 and introduction of unsaturation on N by AT-alkylation produced 241 which was followed by conversion of the carbethoxy function to an aldoxime 242. lOOC reaction of 242 led to stereoselective formation of various tricyclic systems 243. This versatile method thus allows attachment of various unsaturated side chains that can serve for generation of functionalized five- or six-membered (possibly even larger) rings. [Pg.35]


See other pages where Alkaloid pyrrolizidine is mentioned: [Pg.102]    [Pg.419]    [Pg.20]    [Pg.5]    [Pg.12]    [Pg.271]    [Pg.141]    [Pg.102]    [Pg.419]    [Pg.20]    [Pg.5]    [Pg.12]    [Pg.271]    [Pg.141]    [Pg.478]    [Pg.246]    [Pg.799]    [Pg.822]    [Pg.824]    [Pg.254]    [Pg.345]    [Pg.312]    [Pg.329]    [Pg.129]    [Pg.131]    [Pg.259]    [Pg.493]    [Pg.864]    [Pg.866]   
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Alkaloid pyrrolizidines

Alkaloid pyrrolizidines

Alkaloids pyrrolizidine ingestion

Alkaloids, macrocyclic pyrrolizidine

Ammonium pyrrolizidine alkaloids

Asymmetric synthesis of pyrrolizidine alkaloids

Boraginaceae, pyrrolizidine alkaloids

Carcinogens pyrrolizidine alkaloids

Chelaner antarcticus pyrrolizidine alkaloids

Compositae pyrrolizidine alkaloids

Ellen W. Baxter and Patrick S. Mariano The Loline Group of Pyrrolizidine Alkaloids

Hepatic pyrrolizidine alkaloid toxicity

Herbal medicines, pyrrolizidine alkaloids

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Lepidoptera pyrrolizidine alkaloids

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Of pyrrolizidine alkaloids

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Poisoning, human, pyrrolizidine alkaloids

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Pyrrolizidin

Pyrrolizidine

Pyrrolizidine Alkaloids and Their N-Oxides

Pyrrolizidine alkaloid , toxicosis

Pyrrolizidine alkaloid detection

Pyrrolizidine alkaloid monocrotaline

Pyrrolizidine alkaloid monocrotaline metabolic activation

Pyrrolizidine alkaloid monocrotaline structure

Pyrrolizidine alkaloids (PAs)

Pyrrolizidine alkaloids Eschenmoser coupling reaction

Pyrrolizidine alkaloids Subject

Pyrrolizidine alkaloids acute

Pyrrolizidine alkaloids biosynthesis

Pyrrolizidine alkaloids chiral synthesis

Pyrrolizidine alkaloids dehydrogenation

Pyrrolizidine alkaloids derivatization

Pyrrolizidine alkaloids detoxification

Pyrrolizidine alkaloids distribution

Pyrrolizidine alkaloids from pyrrolidines

Pyrrolizidine alkaloids hepatic veno-occlusive disease

Pyrrolizidine alkaloids localization

Pyrrolizidine alkaloids mechanism

Pyrrolizidine alkaloids metabolic activation

Pyrrolizidine alkaloids poisonings

Pyrrolizidine alkaloids structural determinants

Pyrrolizidine alkaloids structural types

Pyrrolizidine alkaloids total synthesis

Pyrrolizidine alkaloids toxicity mechanism

Pyrrolizidine alkaloids via cycloaddition

Pyrrolizidine alkaloids via cyclopropane ring opening

Pyrrolizidine alkaloids, absorption

Pyrrolizidine alkaloids, hepatotoxicity

Pyrrolizidine alkaloids, synthesis

Pyrrolizidine group alkaloids

Pyrrolizidines pyrrolizidine alkaloids

Pyrrolizidines quinolizidine alkaloids

Senecio jacobaea, pyrrolizidine alkaloids

Solid pyrrolizidine alkaloids

The Pyrrolizidine Alkaloids

Thin layer chromatography pyrrolizidine alkaloids

Toxicity pyrrolizidine alkaloids

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Utetheisa ornatrix pyrrolizidine alkaloids

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