Ceftazidime Amikacin

Noninterfering acetaminophen, amikacin, ceftazidime, ceftriaxone, genteimicin, nafcillin, phenytoin, ticarcillin, tobramycin, vancomycin... 

Gram-negative cocci Non-tuberculous mycobacteria Nocardia Ceftriaxone 50 mg/mL or Ceftazidime 50 mg/mL or Fluoroquinolones 3 mg/mL Amikacin 20-40 mg/mL or Oral clarithromycin 500 mg every 12 hours Amikacin 20-40 mg/mL or Trimethoprim 16 mg/mL and sulfamethoxazole 80 mg/mL wearers as indicated... 

Warfarin sodium may be adsorbed to PVC and intravenous infusion sets but may be minimized with glass containers or polyethylene-lined containers. Warfarin sodium is incompatible with solutions of adrenaline hydrochloride, amikacin sulfate, metaraminol tartrate, oxytocin, promazine hydrochloride, tetracycline hydrochloride, aminophylline, bretylium tosylate, ceftazidime, cimetidine hydrochloride, ciprofloxacin lactate, dobutamine hydrochloride, esmolol hydrochloride, gentamicin sulfate, labetalol hydrochloride, metronidazole hydrochloride, and vancomycin hydrochloride.130131... 

Endophthalmitis Vancomycin and amikacin or vancomycin and ceftazidime Intravitreal... 

Retinal damage in the farm of macular inferction has occurred after intravitreal administration of gentamicin. Because amikacin is less toxic when injected intravitreally, the current recommendation far treatment of postoperative endophthalmitis is intravitreal amikacin (or ceftazidime) for gram-negative coverage. 

Ototoxicity was observed in three of 195 patients who received amikacin (15 mg/kg/day) with either cefepime (2 g bd) or ceftazidime (2 g tds) (5). Two patients had severe loss of hearing, which persisted after drug withdrawal and resulted in permanent disability. The other had mild ototoxicity that required no action and resolved spontaneously. 

Erman M, Akova M, Akan H, Korten V, Ferhanoglu B, Koksal I, Cetinkaya Y, Uzun O, Unal S Febrile Neutropenia Study Group of Turkey. Comparison of cefepime and ceftazidime in combination with amikacin in the empirical treatment of high-risk patients with febrile neutropenia a prospective, randomized, multicenter study. Scand J Infect Dis 2001 33(11) 827-31. 

Rolston KV, Berkey P, Bodey GP, Anaissie EJ, Khardori NM, Joshi JH, Keating MJ, Holmes FA, Cabanillas FF, Elting L. A comparison of imipenem to ceftazidime with or without amikacin as empiric therapy in febrile neutropenic patients. Arch Intern Med 1992 152(2) 283-91. 

Schaad UB, Wedgwood-Krucko J, Guenin K, Buehlmann U, Kraemer R. Antipseudomonal therapy in cystic fibrosis aztreonam and amikacin versus ceftazidime and amikacin admiuistered intravenously followed by oral ciprofloxacin. Eur J Clin Microbiol Infect Dis 1989 8(10) 858-65. 

The efficacy and safety of pefloxacin, 15-20 mg/kg bd for 14—28 days in combination with ceftazidime and amikacin, have been investigated in 21 children (aged 7-16 years) with mncoviscidosis or aplastic anemia (2). Combined therapy had good chnical efficacy. Arthropathy developed freqnently and children at risk were over 10 years old and had a history of allergies. 

In a retrospective cost analysis, the records of 527 patients with acute leukemia were studied (11). They had been treated in a multicenter, randomized trial for febrile neutropenia with ceftazidime and amikacin plus either teicoplanin (6 mg/kg in a single dose n — 275) or vancomycin (30 mg/kg/day in 2 doses n — 252). Qinical responses were equivalent. Again the higher acquisition costs for teicoplanin were counterbalanced by the lower incidence of adverse events and easier administration, resulting in overall similar costs for both regimens. A total of 8% of patients treated with vancomycin reported adverse events compared with 3.2% of patients treated with teicoplanin. Rashes occurred in 6.0 versus 1.4% respectively. Nephrotoxicity, ototoxicity, fever, and hypotension occurred in very few patients. 

In the second study [16], 62 subjects were treated with intravenous ceftazidime and amikacin. The treatment group also received aerosolized amikacin 100 mg twice daily. Treatments were given for an average of 15 days, and subjects were reevaluated four to six weeks after hospital discharge. During treatment, transient improvements in several outcome measures were noted (e.g., x-ray score, inflammation indices, and percentage underweight) however, there were no differences in any measure at the final evaluation point. As in the earlier study, eradication of bacteria from sputum was also transient. 

Schaad RB, Wedgwood-Kruko J, Suter S. Efficacy of inhaled as adjunct to intravenous combination therapy (ceftazidime and amikacin) in cystic fibrosis. J Pediatr 111 599-665, 1987. 

Giamarellou H, Bassaris HP, Petrikkos G, et al. Monotherapy with intravenous followed by oral high-dose ciprofloxacin versus combination therapy with ceftazidime plus amikacin as initial empirical therapy for granu-... 

EORTC International Antimicrobial Therapy Cooperative Group. (1987). Ceftazidime combined with short and long course amikacin for empirical therapy of gram-negative bacteraemia in cancer patients with granulocytopenia. New Eng J Med, 317, 1692-1698. 

Alfaro DV III, Hudson SJ, Kasowski EJ, et al. Experimental pseudomonal posttraumatic endophthalmitis in a swine model. Treatment with ceftazidime, amikacin, and imipenem. Retina 1997 17(2) 139-145. 

Ng EW, D Amico DT. Therapeutic efficacy of intravitreal ceftazidime, imipenem, and amikacin in a swine model of posttraumatic Pseudomonas aeruginosa endophthalmitis. Retina 1997 17(5) 464-465. 

Neutropenic patients—For suspected bacteremia in neutropenic patients, ceftazidime, imipenem, meropenem, or cefepime, each alone or in more seriously ill patients with an aminoglycoside (gentamicin, tobramycin or amikacin), would be a reasonable first choice. 

A fluoroquinolone a tetracycline gentamicin A fluoroquinolone amikacin a tetracycline trimethoprim-sulfamethoxazole cefotaxime, ceftizoxime, ceftriaxone, cefepime, or ceftazidime Gentamicin, tobramycin or amikacin trimethoprim-sulfamethoxazole ciprofloxacin, ticarcillin, mezlocillin, or piperacillin aztreonam cefotaxime ceftizoxime ceftriaxone cefepime or ceftazidime Ampicillin gentamicin, tobramycin, or amikacin carbenicillin, ticarcillin, mezlocillin, or piperacillin gentamicin, tobramycin, or amikacin amoxicillin/clavulanic acid ticarcillin/clavulanic acid piperacillin/tazobactam ampicillin/sulbactam trimethoprim-sulfamethoxazole imipenem or meropenem aztreonam a fluoroquinolone another cephalosporin... 

Gentamicin or amikacin cefotaxime, ceftizoxime, ceftriaxone, cefepime, or ceftazidime aztreonam trimethoprim-sulfamethoxazole carbenicillin, ticarcillin, mezlocillin, or piperacillin a fluoroquinolone... 

Ceftazidime, imipenem, meropenem, aztreonam, cefepime -i- tobramycin, gentamicin, or amikacin ciprofloxacin... 

Noninterfering acetaminophen, N-acetylprocainamide, amikacin, amitriptyline, ampicil-lin, carbamazepine, cefamandole, cefazolin, cefoperazone, cefotaxime, cefoxitin, ceftazidime, ceftizoxime, cephalexin, cephalothin, cephapirin, chloramphenicol, ciprofloxacin, clonazepam, (yclosporine, desipramine, digoxin, disopyramide, ethosuximide, gentamicin, haloperidol, imipramine, kanamycin, lidocaine, mezlocillin, netilmicin, nortriptyline, phenobarbital, phenytoin, primidone, procainamide, propranolol, quinidine, salicylic acid, streptomycin, sulfamethoxazole, theophylline, thiamphenicol, ticarcillin, tobramycin, trimethoprim, vancomycin... 

Noninterfering acyclovir, amikacin, amphotericin B, cefazolin, ceftazidime, clindamycin, gentamicin, metronidazole, piperacillin, trimethoprim, sulfamethoxazole... 

Guiso, G. Rambaldi, A. Dimitrova, B. Biondi, A. Caccia, S. Determination of orally administered all-trans-retinoic acid in human plasma by high-performemce liquid chromatography. J.Chromatogr.B, 1994, 656, 239—244 [all-trans-retinyl acetate (IS) extracted metabolites, isotretinoin, tretinoin LOD 10 ng/mL pharmacokinetics non-interfering allopurinol, amikacin, aracytin, ceftazidime, ciprofloxacin, doxorubicin, fluconazole, prednisone]... 

The nephrotoxicity of various combinations of antibiotics was assessed in 171 cancer palienls. In Ihose receiving an aminoglycoside with a third generation cephalosporin, the most nephrotoxic combinations were found to be gentamicin with cefotaxime (although another study did not find this combination to be nephrotoxic ) and amikacin with ceftriaxone, where 5 of 20 and 5 of 13 patients, respectively, had increased serum creatinine. The following combinations were found to be safer amikacin with cefoxitin or ceftazidime, gentamicin with cefoxitin, and netilmicin with cefotaxime. ... 

A study in healthy subjects found that ceftazidime may increase the levels of amikacin. ... 

Adamis G, Papaioannou MG, Giamarellos-Bourboulis EJ, Gargalianos P, Kosmidis J, Gia-marellouH, Pharmacokinetic interactions of ceftazidime, imipenem andaztreonam witii amikacin in healthy volunteers, IntJAntimicrob Agents (2004) 23,144-9,... 

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