Ceftazidime

In the synthesis of ceftazidime (40) (Fig. 8), the protected, preassembled arninothiazole side chain [68672-66-2] (60) is coupled to a protected 7-ACA first and the C-3 displacement step carried out last. By way of contrast, in the synthesis of ceftriaxone (39) (Fig. 9), the preformed C-3 substituent is introduced onto the cephalosporin nucleus in the first step and then the acyl-amino side chain is introduced. This last step is noteworthy for two reasons in that it demonstrates the use of an activated thio ester in the coupling step and that no protecting group chemistry is requited (192,193). 

S. Bompadre, E. Eeixante, E. P. A16 and E. Eeone, On-line solid-phase exti action of ceftazidime in serum and determination by high-perfoimance liquid chi omatography , 7. Chromatogr. B 669 265-269 (1995). 

Z)-2-(2-tert-Butoxycarbonylprop-2-o xy im i no)-2-(2-tri ty lami no-thia20l-4-yl)acetic acid Ceftazidime... 

QHiqO 141-97-9) see Aminophenazone Baclofen Cefotaxime Ceftazidime Chloroquine Cloricromen Cloxacillin Dipyridamole Felodipine Flutoprazepam Hymecromone Kawain Lacidipine Leflunomide Methylthiouracil Nevirapine Nitrendipine Oxacillin Pentoxifylline Propyphenazone Sulfamerazine acetoacetic acid 4-(trifluoromethyl)anilide (C H (,F3N02 351-87-1) see Leflunomide acetoacetyl chloride... 

C45H44N4O7S2 73547-69-0) see Ceftazidime ( )-S-[[4-[[(2-carboxyethyl)amino]carhonyl]phenyllazo]-2-hydroxybenzoic acid... 

C,4H, N203 86499-52-7) see Benazepril ethyl (Z)-2-(2-aminathiazol-4-yl)-2-hydroxyiminoacetate (C7H(,N303S 64485-82-1) see Carumonam Ceftazidime ethyl 2-(2-amino-4-thiazolyl)-2(Z)-hydFoxyiminoacetate... 

C2 H23N303S 66338-99-6) see Ceftazidime 2-etbyl-5-hydroxy-iV-(2-(l//-indol-3-yl)ethyl]pentanamide (C H24N202 52250-53-0) see Vincamine ethyl 2-hydroxyisobutyrate... 

C,7H 5CI 76-83-5) see Candesartan cilexetil Cefotaxime Ceftazidime Indeloxacine Losartan potassium Remoxipride Zidovudine... 

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