Allergic rhinitis decongestants

Decongestants are used to treat the congestion associated with rhinitis, hay fever, allergic rhinitis, sinusitis, and the common cold. In addition, they are used in adjunctive therapy of middle ear infections to decrease congestion around the eustachian tube Nasal inhalers may relieve ear block and pressure pain during air travel. Many can be administered orally as well as topically, but topical application is more effective than the oral route. 

Antihistamines and intranasal corticosteroids are considered first-line therapy for allergic rhinitis, whereas decongestants, mast cell stabilizers, leukotriene modifiers, and systemic corticosteroids are secondary treatment options. 

As a nasal decongestant in allergic rhinitis, with or without the addition of antazoline or sodium chromoglycate. 

Allergic rhinitis Two percent aqueous nasal spray (EINTAL nasal spray) is used for nasal decongestion although it is not a nasal decongestant. 

Antihistamines are the most frequently used agents in the treatment of sneezing and watery rhinorrhea associated with allergic rhinitis. -Histamine receptor blockers, such as diphenhydramine, chlorpheniramine, loratadine, terfenadine and astemizole (see p. 422), are useful in treating the symptoms of allergic rhinitis caused by histamine release. Combinations of antihistamines with decongestants (see below) are effective when congestion is a feature of rhinitis. They differ in their ability to cause sedation, and their duration of action. 

Antihistamines and intranasal corticosteroids are the first-line treatments for allergic rhinitis. Sodium cromoglicate, ipratropium bromide and decongestants, are alternative or add-on treatments. Drug treatment should be selected according to the severity, frequency and duration of symptoms ... 

Use Allergic rhinitis, including hay fever and acute coryza (profuse nasal discharge). Provides longer-lasting relief than nasal decongestants Half-life 9-15 hours Onset 15-30 minutes Peaks 30-60 minutes... 

Less serious allergic rhinitis and hay fever are treated mainly with antihistamines and decongestants. 

Loratadine/pseudoephedrine sulfate is an antihistamine/ decongestant. Loratadine competitively antagonizes histamine at the Hj receptor. Pseudoephedrine causes vasoconstriction and subsequent shrinkage of nasal mucous membranes by alpha-adrenergic stimulation, promoting nasal drainage. They are indicated in the relief of seasonal allergic rhinitis. 

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