Allergic rhinitis risks

Allergic rhinitis is a risk factor for asthma up to 78% of asthma patients have nasal symptoms, and about 38% of allergic rhinitis patients have asthma. 

The large body of epidemiological studies have clearly shown that allergic rhinitis and asthma are frequent diseases, and that both diseases obviously still increase in prevalence [4, 5]. However, without any doubt, there is a direct link between rhinitis and asthma. Several studies in a large number of patients have clearly shown that rhinitis sufferers have a 3- to 7-fold increased risk to also develop asthma within 7 years compared to normal controls. Most of this development actually lies in the early years of childhood, as was recently shown in the MAS and PAT studies [6, 7], In the first study, 5-year-old children sensitized to pollen with allergic rhinitis symptoms developed asthma within 2 years... 

It is recommended that allergic rhinitis should be considered as a risk factor for asthma along with other known risk factors. 

Dold S, Wjst M, von Mutius E, et al Genetic risk for asthma, allergic rhinitis, and atopic dermatitis. Arch Dis Child 1992 67 1018-1022. (Ill)... 

The prospective Boston Home Allergens and Asthma Study [192(IIIC)] was a birth cohort study which followed 448 infants, at high risk for atopy, from birth to 5 years. This study excluded children who were treated with antibiotics for wheezing. There was no association between antibiotic use and asthma, allergic rhinitis or eczema at age 5. 

Tobacco smoke exposure is undoubtedly an important risk factor for allergic rhinitis and asthma. However, the precise role of chemicals from smoke on IgE sensitisation is not known, and ftirther studies are necessary. Both active smokers and non-smokers exposed to ETS have been found to be affected adversely. ETS - consisting of mainstream smoke which has been inhaled and exhaled by the primary smoker, and sidestream smoke which arises directly from a burning cigarette - contains many agents that have pathological effects on human tissues [251 (IV), 252(111)]. 

The role of allergic rhinitis in the development of acute otitis media or chronic middle ear effusion remains controversial. Children with allergic rhinitis appear to be at greater risk of these conditions because of nasal obstruction, insufflation of nasal secretions into the... 

Allergic rhinitis is clearly a risk factor for asthma. As many as 78% of asthma patients have nasal symptoms, while about 38% of allergic rhinitis patients have asthma. Asthma is more common in those with perennial than seasonal allergic rhinitis, and it is less likely to be outgrown when associated with allergic rhinitis. ... 

CHRONIC HEALTH RISKS susceptible to illnesses similar to colds and allergic rhinitis disturbances of liver functions decreased number of leukocytes in blood pulmonary edema may cause genetic damage may cause cancer. 

Clemastine Fumarafe (Tavist, Dayhist, Antihist-1) [OTC] [Antihistamine] Uses Allergic rhinitis Sxs of urticaria Action Antihistamine Dose Adults Peds. >12 y 1.34 mg bid to 2.68 mg dd max 8.04 mg/d <6 y 0.335-0.67 mg/d into (max 1.34 mg/d) 2-3 d. 6-12 y 0.67-1.34 mg bid (max 4.02 /d) Caution [C, M] BOO do not take w/ MAOI Contra NAG Disp Tabs, syrup SE Drowsiness, dyscoordinadon, epigastric distress, urinary retendon Interactions T Effects V/ CNS depressants, MAOIs, EtOH i effects OF heparin, sulfonylureas EMS Use odier CNS depressants w/ caudon concuirent EtOH use can T CNS effects T risk of photosensidvity Rxns OD May cause CNS... 

Older adults are at most risk for adverse effects associated with first-generation antihistamines (68). Because second- and third-generation antihistamines have fewer sedative and anticholinergic adverse effects than first-generation antihistamines, they are generally recommended for the treatment of allergic rhinitis in older patients (66). 

Lumry W. Treatment paradigms for allergic rhinitis. IRINE Optimal Paradigms for Allergy and Asthma Managed Care Quality of Life, Outcome and Risks/Beneflts Assessments, Short Hills, NJ, April 10, 1999. 

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