Allergic rhinitis cromolyn

Cromolyn sodium and ipratropium bromide offer two additional approaches for treating allergic rhinitis. Cromolyn sodium is a mast cell stabilizer. Increased interest in this product has resulted from it becoming available without a prescription. Ipratropium bromide is an anticholinergic agent useful in pereimial allergic rhinitis. 

Intranasal corticosteroids are the most effective treatment for allergic rhinitis during pregnancy. Beclomethasone and budesonide have been used most. Nasal cromolyn and first-generation antihistamines (chlorpheniramine, tripelennamine, and hydroxyzine) are also considered first-line therapy. Loratadine and cetirizine have not been as extensively studied. 

Cromolyn sodium (Nasalcrom), a mast cell stabilizer, is available as a nonprescription nasal spray for symptomatic prevention and treatment of allergic rhinitis. 

Ratner PH, Ehrlich PM, Fineman SM, et al. Use of intranasal cromolyn sodium for allergic rhinitis. Mayo Clin Proc. 2002 77 350-354. 

Synonyms cromolyn sodium disodium cromoglycate Trade names Colimune Crolom Cromlom Cromoptic Fivent Gastrocrom (Celltech) Intal (Monarch) Nalcrom Nasalcrom (Pfizer) Opticrom (Allergan) Rynacrom Indications Allergic rhinitis, asthma, mastocytosis Category Mast cell stabilizer Half-life 80 minutes... 

Cromolyn generally is used prophylactically for bronohial asthma (as an inhaled powder), for prevention of exercise-induoed bronohospasm, and for seasonal and perennial allergic rhinitis (nasal solution). Topically, it also is used as eye drops for allergic conjunctivitis and keratitis. In... 

Intranasal cromolyn sodium is thought to inhibit mast cell degranulation and prevent the allergic reaction leading to the manifestations of allergic rhinitis (54). Clinical studies show pretreatment with intranasal cromolyn sodium 4-7 days... 

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