Adhesion molecule receptors

Human rhinoviruses (HRV) are members of the Picornaviridae family. The HRVs are classified according to their receptor specificity into members of the major and minor groups. The 87 members of the major-group viruses bind to the intracellular adhesion molecule receptor 1 (ICAM-1), whereas the 12 serotypes of the minor group bind to members of the low-density lipoprotein receptor family (LDLR) [42]. Rhinoviruses cause more than a billion cases of the common cold each year and are also associated with asthma exacerbations [43,44]. Statistically, one encounters one to three infections per year on the average [45]. As a result, rhinoviral infections are responsible for 25 million days of missed work in the USA [46]. 

Muller N, Riedel M, Hadjamu M, Schwai z MJ, Ackenheil M, Gruber R (1999) hicrease m expression of adhesion molecule receptors on T helper cells during antipsychotic treatment and relahoiiship to blood-braui baiiier peimeability in schizophrenia. Am J Psychiatry 156 634-636. 

Technetium ( Tc) Apeitide. This new radiotracer is a synthetic peptide that binds to the GPlIb/Illa adhesion-molecule receptors found on activated platelets. This allows the detection of acute venous thrombosis and is Food and Drug Administration (FDA)-approvcd for detection of acute lower extremity deep venous thrombosis. A lyophilized preparation of 100 yug of bibapeitide in the presence of heat will split and then complex to 20 mCi Tc-99m pertechnetate. Images of area of concern arc acquired at 10 and 60 minutes. 

YV Receptors A Growth Victors 11 Cell adhesion molecules Receptors to ECM molecules... 

Because high levels of ganglio-series gangliosides are found in neural tissues, ganglioside research has traditionally been linked with neurochemistry. However, aside from their role as cell type-specific antigens, the real function of gangliosides remains obscure (see Chapter 6). In comparison with studies of functional proteins, enzymes, antibodies, adhesion molecules, receptors, etc.,... 

Integrins, selectins, cadherins, claudins and other cell adhesion molecules are involved in the interaction of cells with other cells or with extracellular matrix components. Some of them also serve as receptors by inducing outside-in or additional inside-out signaling. 

Inhibition of inflammatory cytokines (Fig. 2) Humanized monoclonal anti-TNF antibodies (Infliximab (Remicade ), Adalimumab (Humira )) bind with high selectivity to human TNF-a and neutralize its activity. Thereby, infliximab decreases the effects of enhanced TNF levels during inflammatory disease such as production of proteases, chemokines, adhesion molecules, cyclooxygenase products (prostaglandins), and proinflammatory molecules such as interleukin-1 and -6. The antibodies may also recognize membrane-bound TNF-a on lymphocytes and other immune cells. These cells may subsequently become apoptotic or are eliminated via Fc-receptor-mediated phagocytosis. 

CD163 (Scavenger receptor) Adhesion molecules (ICAM-1, E-selectin)... 

NF-xB activates genes encoding MHC class I antigens, IL-1, TNFa, IL-6, the interleukin-2 (IL-2) receptor, some acute-phase proteins and the adhesion molecules, vascular cell adhesion molecule-1 (VCAM-1) (lademarco... 

CD44 Known to be z leucocyte adhesion molecule also known as hyaluronic acid cell adhesion molecule (H-CAM), Hermes antigen, extracellular matrix receptor III (ECMIII) present on polymorphonuclear leucocytes CI)45 Known to be z pan leucocyte marker... 

CD49 Cluster of differentiation 49 CD51 Known to be vitronectin receptor alpha chain CD54 Known to be Intercellular adhesion molecule-1 also known as ICAM-1... 

EPA Eicosapentaenoic acid EpDIF Epithelial-derived inhibitory factor also known as epithelium/derived relaxant fector EPO Eosinophil peroxidase EPOR Erythropoietin receptor EPR Effector cell protease EPX Eosinophil protein X ER Endoplasmic reticulum ERCP Endoscopic retrograde cholangiopancreatography E-selectin Endothelial selectin formerly known as endothelial leucocyte adhesion molecule-1 (ELAM-1)... 

Mac- Macrophagp-l antigen a member of the /3-2 integrin family of cell adhesion molecules (also abbreviated to M41), ako known as monocyte antigen-1 (M-1), complement receptor-3 (CR3), CDllb/CD18... 

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