Rhinoviral infections

Human rhinoviruses (HRV) are members of the Picornaviridae family. The HRVs are classified according to their receptor specificity into members of the major and minor groups. The 87 members of the major-group viruses bind to the intracellular adhesion molecule receptor 1 (ICAM-1), whereas the 12 serotypes of the minor group bind to members of the low-density lipoprotein receptor family (LDLR) [42]. Rhinoviruses cause more than a billion cases of the common cold each year and are also associated with asthma exacerbations [43,44]. Statistically, one encounters one to three infections per year on the average [45]. As a result, rhinoviral infections are responsible for 25 million days of missed work in the USA [46]. 

Commercial pomegranate juice is being examined in numerous clinical trials to determine its potential use in controlling prostate gland hypertrophy, cancer, diabetes, the common cold, rhinoviral infections, and development of vascular disease. This is an achievement made possible almost exclusively by the dedication of manufacturers to have their juice products tested in clinical trials by independent scientists. 

The exacerbation of asthmatic responses is most frequently caused by a pulmonary viral infection, such as influenza, rhino, or adenovirus infections (81-89). Recent data has indicated that rhinoviral infections are the most common cause of severe asthma exacerbations. In addition to exacerbating asthmatic responses, severe respiratory syncytial virus (RSV) infections early in childhood appears... 

There are important differences between mice and men and between enteroviral paralytic illness and rhinoviral upper respiratory tract infections. 

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