Integrin family

Fibronectin receptor is a two-chain glycoprotein of the integrin family that serves as a transmembrane linker by binding to talin on the cytoplasmic side and to fibronectin on the external side of the membrane. The pull exerted by stress fibers on attached structures may be produced by bipolar assemblies of nonmuscle myosin molecules producing a sliding of actin filaments of opposite polarity. 

CD11a/CD18,CDllb/CD18, CDllc/CD18 j Adhesion molecules (members of the 1 integrin family) Deficient in leukocyte adhesion deficiency type 1 (MIM 116920)... 

LFA-1 Leucocyte function-associated antigcn-1 also known to be member of the (3-2 integrin family of cell adhesion molecules... 

Milner, R. and Campbell, I. L. The integrin family of cell adhesion molecules has multiple functions within the CNS. J. Neurosci. Res. 69 286-291,2002. 

The structure of the integrin family has been deduced largely from the cDNA sequences of the cloned genes. All integrins comprise a- and fl-subunits, and the ligand binding that occurs at the binding site comprises an interaction between the two subunits. The a-subunits can combine with dif-... 

Macromolecular complexes of proteins and carbohydrate present in the ECM serve not only as adhesive keeping cells in their correct positions but also facilitate control of cell activity by signalling through membrane proteins such as the integrin family of receptors. Glycoproteins are mainly protein with covalently attached carbohydrate whereas proteoglycans are predominantly complex carbohydrates secured on a protein framework. 

Type I collagen can interact with various other molecules in the extracellular matrix and on the cell surface. Cell receptors of type I collagen have been identified and include the heterodimeric integrin family receptors, ctl, 0 2, olO, and ol 1, especially o2/3l, the receptor tyrosine kinase discoidin domain receptor (DDR), and the heparan sulfate membrane proteoglycan syndecan family... 

The most abundant member of the platelet beta 3 integrin family is also... 

Integrins. The integrin family has been identified as excellent candidates for the development of target specific cancer therapies.29 Integrins are heterodimeric glycoproteins that consist of a and P subunits, which combine to form the various types of integrins. Currently, 18 a subunits, 8 P subunits, and approximately 22 different integrins have been identified.29,30... 

Complement proteins opsonize bacteria for phagocytosis via integrin family, a(3 het-erodimeric CRs on the macrophages. Unlike the FcR-mediated process, GR-mediated... 

Galvete, J. J., Henschen, A., and Gonzalez-Rodriguez, J. (1991). Assignment of disulphide bonds in human platelet GPllla. A disulphide pattern for the beta-subunits of the integrin family. Biochem. J. 274, 63-71. 

Shakoori AR. Phosphorylation and glycosylation interplay Protein modifications at hydroxy amino acids and prediction of signaling functions of the human beta(3) integrin family. J. Cell Biochem. 2006 99 706-718. 41. 

A functional integrin is a heterodimeric protein complex consisting of an a and a P subunit. So far, the mammalian integrin family consists of 8 P subunits and 18 a subunits, which are known to assemble into 24 distinct integrins (Fig. 1). The different combination of subunits accounts for heterodimer specificity, with certain integrins showing preference for particular ECM... 

Calvete IJ, Hensdien A, Gonzaleas-Rodriguez J Assignment of disulfide bonds in human platelet GPIHa A disulfide pattern for the b-subunits of the integrin family. Biochem J 274 63-71,1991. 

Hemler, M. E., VLA proteins in the integrin family structures, functions and their role on leucocytes, Annu. Rev. Immunol., 8, 365, 1990. 

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