Wounds micro-organisms

When considering antimicrobial therapy in a patient with fever, one should answer the following questions. First, is the fever caused by an infection If affirmative, data are needed to determine the severity of the infection, the site of infection, and the causal micro-organism(s). Second, when the cause of the fever is infectious, one should ask is treatment with antimicrobial drugs needed Many soft tissue infections including impetigo and decubital ulcers are best treated with local antiseptics and/or wound debridement without the use of antibiotics. If the chance to cure the infection with antimicrobial... 

In the environment of the burn the compound slowly dissociates into silver and sulfadiazine (30). The silver ion is the antimicrobially active part of the compound and acts by interaction with the micro-organism. Possibly sulfadiazine has a supportive antibacterial effect, but the concentration seems to be subinhibitory (30). The role of sulfadiazine may be to create a sustained delivery of silver ions into the wound environs. 

Dextranomer has a pore size that produces an exclusion limit of 1000-8000 Da, which precludes the sorption of viruses and bacteria. Micro-organisms are removed from the wound by the capillary action between the beads, a function that is absent from the paste formulation, which however demonstrates a marked increase in absorbing capacity for malodorous elements and pain producing compounds released during the inflammatory response. 

Free silver ions are the active components of antimicrobial silvers, and it has been shown that as little as one part per million of elemental silver in solution is an effective antimicrobial. Materials such as polymers, charcoal, and hydrocolloids when formulated with silver not only aid wound management and healing but also regulate its release into the wound environment and surrounding tissues. Silver ions kill micro-organisms by inhibiting cellular respiration and cellular function. " It is known that their mode of action is exerted by binding cysteine residues on the cell walls of yeasts such as C. albicans thereby... 

Nifurprazine has a bactericidal action against micro-organisms in the logarithmic growth phase as well as in the stationary phase > . A 50 per cent content of human serum in the culture medium does not interfere with the bactericidal activity of the compound. Further clinical investigations showed that the compound is very effective against wound infections and a preparation for topical application was marketed in 1966. 

Sea water is a diluted suspension of bacteria, many of which are harmful to man and cause various infections (external otitis, gastroenteritis, pneumonia). Wounds occurring in the marine environment from any cause may therefore evolve very easily into infection. The micro-organisms isolated from infected wounds include bacteria present in sea water (vibrioni, Entero-bacter, Escherichia coli, pseudomonasy Achromobacter xylosoxidansy Acinetobacter calcoaceticus) and normal skin flora (staphylococci, streptococci). The treatment of wounds infected by marine micro-organisms includes debridement of necrotic tissue, removal of... 

---