Delivery, sustained

S.E. Zale, DRUG DELIVERY Sustained Delivery of Proteins for Novel Therapeutic Products. Science, 1998. 281(5380) ... 

Capsulation Controlled drug delivery Sustained drug release... 

J. R. Robinson, ed.. Sustained and Controlled Kelease Drug Delivery Systems, Marcel Dekker, Inc., New York, 1978, p. iii. 

MaePhee, M.J., Campagna, A., Best, A., Kidd, R. and Drohan, W., Fibrin sealant as a delivery vehicle for sustained and controlled release of chemotherapy agents. In Sierra, D. and Saltz, R. (Eds.), Surgical Adhesives and Sealants, Current Technology and Applications. Technomic, Lancaster, PA, 1996, pp. 145-154. 

Electric vehicle (EV) is an abbreviated term for battery electric vehicle, which is a vehicle that uses energy from a batteiy to operate an electric motor that rotates the wheels. Throughout the twentieth century, a wide array of electric cars, trucks, buses, bikes, and scooters have been developed. However, except for the golf cart and special delivery vehicles, none has experienced any sustained commercial success. 

A., and Hower, J. F., Sustained delivery of narcotic antagonists from lactic.glycolic acid copolymer implants, in Polymeric Delivery Systems (R. J. Kostelnik, ed.), Gordon and Breach, New York, 1978, Chap. 4. 

Pitt, C. G., Jeffcoat, A. R., Zweidinger, R. A., and Schindler, A., Sustained drug delivery systems. I. The permeability of poly(e-caprolactone), poly(DL-lactic acid), and their copolymers, J. Biomed. Mater. Res., 13. 497-507, 1979. 

Hendren, R. W., Reel, J. R., and Pitt, G. C., Measurement of drug release rates from sustained delivery devices in vivo. Fort Lauderdale, Florida, Controlled Release Society, Proc. 11th Int. Symp. Control. Rel. Bioact. Materials. 110-111, 1984. 

YoUes, S., and Sartori, M. F., Degradable polymers for sustained drug release, in Drug Delivery Systems (R. L. Juliano, ed.), Oxford University Press, New York, 1980, pp. 84-111. 

Partially deacetylated chitin, a cellulose-like biopolymer consisting predominantly of N-acetyl-D-glucosamine chains, in the form of films or crosslinked hydrogels has been used for the delivery of drugs (28,29). The suitability of chitin as a vehicle for the sustained release of drugs was examined using indomethacin and papaverine hydrochloride as model drugs (30). In vitro studies showed that over 80% of the indomethacin was released within 7 hr, whereas papaverine hydrochloride dissolved almost immediately. 

In light of the information presented, it appears that liposomes have much to offer as an improved delivery system for inhaled bronchodilators as they can provide sustained release, solubilization, stability, and safety in an inhalable formulation. 

A number of the water-soluble polymers also have adhesive properties which are being extensively evaluated for drug delivery (9). These polymers will adhere to the mucous coating in the gastrointestinal tract, the nose, and the mouth to delay passage and sustain drug release. Those polymers with the best adhesive properties are those with hydroxyl and carboxyl groups. Table II lists some of the bioadhesive polymers and their adhesive properties. 

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