Drugs antimicrobial

It is well documented that antimicrobial agents cause cross-resistance. Use of antibiotics causes alterations in normal microbial flora of the body. The suprain-fection is a common problem associated with antibiotic therapy and is very difficult to treat. Prolonged uses of antibiotics alter the microflora of the intestine and cause vitamin deficiency. Neomycin causes morphologic abnormalities in the intestinal mucosa. 

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Antibiotic and Antimicrobial Drugs. The antimicrobial agents (119) flumequiae (160) and (161), and methylflumequiae (S-25930) (162) and (163) effectively eliminate a number of microbial pathogens via inhibition of the topoisomerase II enzyme of c-DNA containing bacteria (120) (see... 

W. B. Ptatt and R. Eekety, eds.. The Antimicrobial Drugs, Oxfotd Univetsity Ptess, London, 1986. 

A. J. Hutt, J. O Grady, Drug chirality a consideration of the significance of the stereochemistry of antimicrobial drugs, J. Antimicrobial Chemother, 1996, 37, 7-32. 

Antimicrobial drugs are used for the treatment of diseases caused by microorganisms (bacterial or viral infections). 

Unmodified antisense PNA oligomers were also recently shown to downregu-late targeted genes in an amoeba (Entamoeba histolytica) [68]. These results suggest the potential development of PNA as a new class of antimicrobial drugs. 

Rachakonda S, Cartee L. Challenges in antimicrobial drug discovery and the potential of nucleoside antibiotics. Curr Med Chem 2004 11 775-93, 2004. 

Gilbart J., Perry CR. Slocombe B. (1993) High-level mupirocin resistance in Staphylococcus aureus evidence for two distinct isoleucyl-tRNA synthetases. Antimicrob Agents Chemother, 31, 32-38. Godfrey A.J. Bryan L.E. (1984) Intrinsic resistance and whole cell factors contributing to antibiotic resistance, hv. Antimicrobial Drug Resistance (ed. L.E. Bryan), pp. 113-145. New York Academic Press. 

Dexamethasone therapy may reduce antibiotic penetration, so antimicrobial drug dosing may have to be increased (especially vancomycin) to achieve adequate CSF levels. Serum levels of vancomycin should be measured and doses titrated to ensure adequate CNS concentrations. Evaluate whether intraventricular or intrathecal antibiotics are indicated. 

M. Ruff, D. Schotik, J. Bass, and J. Vincent, Antimicrobial drug suspensions a blind comparison of taste of fourteen common pediatric drugs, Pediatr. Infect. Dis. J., 10, 30 (1991). 

J. Guban, D. R. Korver, G. E. Allison and G. W. Tannock, Relationship of dietary antimicrobial drug administration with broiler performance, decreased population levels of Lactobacillus salivarius and reduced bile salt deconjugation in the ileum of broiler chickens. Poultry Science, 2006, 85, 2186-2194. 

Johnsen PJ, Townsend JP, Bohn T et al (2009) Pactors affecting the reversal of antimicrobial-drug resistance. Lancet Infect Dis 9(6) 357-364... 

Seizinger, B., and Loferer, H., DNA microarray technology and antimicrobial drug discovery, Pharmacogenomics, 1, 169-178, 2000. 

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