Wounds epithelization

Obtained data demonstrate that dropping 0.8% aqueous CMS solution (pH 5.5 - 6.0) into eyes afler corneal trauma intensifies inflammatory reaction and activates early processes of elimination of necrotic tissue at the point of trauma. CMS provides limitation of pathological process development in the cornea, and everywhere stimulates processes of wound epithelization. Its use ensures histo-characteristics of the epithelium layer, and arranges orderly fibers of the corneal substance itself. This provokes full comeal recovery and prevents leukoma. 

The total ethanolic extract of the stem bark and its main constituent esculin (1) were found practically non-toxic. They inhibited the classical pathway and alternative pathway of complement activation. The total extract and 1 displayed antiinflammatory activity in both zymosan- and carrageenan-induced paw edema in mice. The extract exhibited a pronounced antioxidative activity and caused intense wound epithelization. The antimicrobial and photodynamic damage prevention properties of the extract and its fractions were dependable on their... 

For debridement of necrotic tissue and liquefication of slough in acute and chronic lesions such as pressure ulcers, varicose, diabetic, and decubitus ulcers, burns, postoperative wounds, pilonidal cyst wounds, carbuncles, and miscellaneous traumatic or infected wounds. Also stimulates vascular bed activity to improve epithelization. 

Short-time epithelization. Fast wound healing... 

A distinctive status of the eye cornea morjrfiology of animals given CMS was epithelization of the whole wound surface. Epithelium growth with immersion into sub-epithelial layer was not observed. Peripheral zones of the wound were covered with a two- to three-layer epithelium wherein a considerable quantity of cells in mitosis was observed. In this zone, collagenic fibers of the cornea itself revealed chemosis, but regulation was observed. Epithelium of adjacent zones comprised four to five layers. In the central sites of the traumatized zone, fibrillogenesis proceeded with higher activity. In contrast to the control and coimective tissue, elements at the wound base contained a few necrotized structures, and much newly formed poorly differentiated connective tissue appeared. 

Trypsin/balsam peru/castor oil is a topical enzyme combination that physiologically debrides tissue and improves epi-thelization by reducing premature epithelial desiccation and comiflcation. It is used in acute and chronic conditions such as varicose ulcers, decubital ulcers, eschar, dehiscent wounds and sunburn relieves pain and promotes healing debrides eschar and necrotic tissue stimulates vascular bed improves epithelization and reduces odor from necrotic wounds. 

Table 10. Epithelization (%) of Wounds with Respect to the Zero Day...

Influence on the proliferation of keratinocytes and thus on the epithelization of the wound. 

Winter, G.D., 1962. Formation of the scab and the rate of epithelization of superficial wounds in the skin of the young domestic pig. Nature 193, 293-294. 

In Ihe evaluation of the different healing times, the group of rats washed with DIPHOTERINE solution presented better and advanced healing of the bums area (4-5°) in comparison with saline solution (in which a 3 ° of wound healing was noted and initial re-epithelization), calcium gluconate (in which there was a 2-3° of wound healing with a delay of detersion) [15]. The evaluation scale adopted had 5° ... 

Lin et al. [110] developed porous BC/chitosan nanocomposite membranes prepared by immersing BC membranes in a chitosan solution followed by freeze-drying. Histological examinations revealed that wormds treated with these BC/chltosan membranes epithelized and regenerated faster than those treated with pure BC membranes and therefore are considered as potential candidates for wound dressing materials. 

The effects of the topically applied vitamin E acetate are very well documented in published studies increased moisturization of the homy layer improvement in skin surface relief evident anti-inflammatory properties increased epithelization of surface wounds improved enzyme activity in the skin prevention of skin damage induced by free radicals protection of properties against sunburn. Vitamin E acetate can increase the natural protection of the skin against UV radiation reduce the amount of the UV damaged cells and protect against damage by reactive oxygen radicals. 

---