DNA damage, prevention

Zempleni J, Teixeira DC, Kuroishi T, Cordonier EL, and Baier S. Biotin requirements for DNA damage prevention. Mutation Res. 733 58—60 (2012). 

These experiments clearly demonstrated that despite the occurrence of extensive DNA damage, particularly DSBs, the embryonic cells kept progressing throughout the cell cycle unaffected, demonstrating that the checkpoint pathway that normally prevents cell progression following DNA damage was not operational in these cells. 

In summary, we showed that DNA damage can elicit a variety of responses in Xenopus early embryos. While y-irradiation induces apoptosis in the embryos, DSB-containing DNA prevents initiation of DNA replication in cell-free extracts derived from eggs. 

Hasegawa R, Chujo T, Sai-Kato K, Umemura T, Tanimura A and Kurokawa Y. 1995. Preventive effects of green tea against liver oxidative DNA damage and hepatotoxicity in rats treated with 2-nitropropane. Food Chem Toxicol 33(11) 961—970. 

Deng XS, Tuo J, Poulsen HE and Loft S. 1998. Prevention of oxidative DNA damage in rats by brussels sprouts. Free Radic Res 28(3) 323-333. 

Decker P, Muller S (2002) Modulating poly (ADP-ribose) polymerase activity potential for the prevention and therapy of pathogenic situations involving DNA damage and oxidative stress. Curr Pharm Biotechnol 3 275-283... 

Acetylation levels of histone and non-histone proteins are regulated upon DNA damage. Retinoblastoma protein pRb controls Gl-S phase transition and phosphorylation of pRb regulates it function. DNA damage induced acetylation of pRb near the phosphorylation sites prevents it phosphorylation and keep pRb in active form thereby leading to growth repression. DNA damage dependant association... 

---