Verification rules

If a quality record was intended to be any document generated or used by the quality system, the definition would surely have indicated this. If we decompose the definition further, requirements for quality are defined in ISO 8402 as the expression of the needs or their translation into a set of quantitatively stated requirements for the characteristics of an entity to enable its realization and examination. Clearly, such a requirement would be a contract, product specification, design requirement, etc. This implies that any product verification records are quality records, but it rules out any recorded information as being a quality record. 

Most of the synthetic work directed toward the higher annulenes was caiiied out by Franz Sondheimer and his students, first at Israel s Weizmann Institute and later at the University of London. Sondheimer s research systematically explored the chemistry of these hydrocarbons and provided experimental verification of Hiickel s rule. 

This theoretical result is completely substantiated by experiment. Goldschmidt,31 from a study of crystal structure data, observed that the radius ratio is large for fluorite type crystals, and small for those of the rutile type, and concluded as an empirical rule that this ratio is the determining factor in the choice between these structures. Using Wasastjerna s radii he decided on 0.67 as the transition ratio. He also stated that this can be explained as due to anion contact for a radius ratio smaller than about 0.74. With our radii we are able to show an even more satisfactory verification of the theoretical limit. In Table XVII are given values of the radius ratio for a large number of compounds. It is seen that the max-... 

The interdependence of the measured values, y, and the analytical values, x, is well-known a priori - mostly by natural laws - and is, therefore, not subject of verification as a rule... 

Observe that we have in this procedure worked out some of the steps previously left to the THEOREM PROVER, The previous procedure involves having the progranmer select a set of inductive assertions and critical points, and then feed this into the computer parts a VERIFICATION CONDITION GENERATOR and a THEOREM PROVER. In this alternative construction we still need inductive assertions as the nature of the Rule of Iteration for WHILE statements shows. Now the inductive assertions are fed directly into the THEOREM PROVER which las been augmented by the special axioms and rules D0,D1,D2,D3 and D4 in addition to all of the usual arithmetic axioms, rules of inference, rules for handling identities and special axioms for the primitives in question (such as the factorial axioms in our example). In effect the THEOREM PROVER works backwards from the output condition and the various inductive assertions using DO - D3 to find what amounts to path verification conditions -... 

It does not seem clear which procedure is easier to implement or more efficient (if and when it works ). Both can be augmented to handle other constructions in any particular programming language. The first procedure is augmented by changing the PATH VERIFICATION CONDITION GENERATOR and the second by adding additional axioms or rules to the THEOREM PROVER. 

Equations (4.11) and (4.26) have to be identical. Simple verification based on the rules for matrix multiplication ... 

There have been attempts to apply formal methods to the representation of organic compounds [1],[2], some attempts to apply artificial intelligence to organic synthesis [3],[4], and numerous attempts to apply the use of molecular orbital calculations to the verification of the validity of compounds in the synthesis route. This effort was a moderate attempt to examine the representation issues involved in writing production rules for Diels-Alder disconnections. 

Pharmaceutical distributors, wholesalers, importers, exporters, all those involved in the distribution chain are key players that, maybe more than others, should improve their capacity to combat counterfeit medicines. It is through the distribution chain that counterfeit medicines reach patients. It is therefore essential that distributors, wholesalers, importers, exporters develop and effectively implement business practices that make the distribution chain as impermeable as possible to counterfeits and open to appropriate verification by national authorities. It is known that in many countries unauthorized trade is widespread and that it is difficult to get unauthorized traders to respect rules and regulations. Yet, if unauthorized trade is the result of many factors, local distributors and retail pharmacists may find themselves part of the problem (for having left important areas of the country without effective supply mechanisms)... 

Special cases and examples. The conditions hitherto introduced are no restrictive, and can be shown to be satisfied in most problems of application. But it must be confessed that some of them are often rather difficult to verify rigorously. It would be desirable to replace them by simpler conditions, especially Condition C) which is rather specific and not adapted to verification. But as we failed in doing so without sacrificing generality, we shall assume them in the following according to necessity, and, as a rule, leave their verification to indivi dual cases. 

Rule 3. Continuing calibration verification must take place at regular intervals during... 

Ing do sequence alignment belong at this position Verification that model Is In agreement with all rules known about normal protein... 

W. T. Borden, H. Iwamura, J. A. Berson, Acc. Chem. Res. 27, 109 (1994). Violations of Hund s Rule in Non-Kekule Hydrocarbons Theoretical Prediction and Experimental Verification. 

Design Qualification (DQ) is the first validation element of a new facility system or equipment, where adherence to the user s specifications and to GMP rules is demonstrated. Installation Qualification (IQ) follows with the verification of adequacy of the area, installation of equipment pipelines, utilities, instrumentation, and conformity of the material used to the project specifications. At the Operational Qualification (OQ) phase, carried out after installation of all equipment, it is verified whether the system, when in operation, complies with the acceptance criteria defined in the validation plan. Once the OQ phase is successfully finalized it is possible to proceed with the calibration procedures, operation and cleaning, operator training, and preventive maintenance program. After IQ and OQ are concluded, it is time for the Performance Qualification (PQ), with the aim of verifying that what was designed, built, and operated results in a product that meets the expected specifications. Production and QC personnel are specially trained for these assessments. The tests can be done with the product of interest or a placebo, and are related to all operations, from raw material reception to product release (EC, 2001). 

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