Vaccine, anti-cancer

Medical - artificial joints, blood bags , anaesthetics, disinfectants, anti-cancer dmgs, vaccines, dental fillings, contact lenses, contraceptives. 

Massa S, Franconi R, Brandi R, Muller A, Mett V, Yusibov V, Venuti A. (2007) Anti-cancer activity of plant-produced HPV16 E7 vaccine. Vaccine 25 3018-3021. 

Combating infectious diseases (viral, protozoal, fungal, bacterial, helminthic) Anti-cancer agent Alleviating allergic reactions Vaccine adjuvant... 

Polymer-based colloidal drug delivery carriers include polymeric micelles, nano- and micro- particles, or coated particles, and hydrogels [886,890,891]. These are being developed for vaccines and anti-cancer drugs, for targeting of specific treatment sites within the body, and as vehicles for ophthalmic and oral delivery. Methods for the creation of multi-layer coatings are reviewed by Sukhorukov [892] (see also Figure 14.4). Numerous examples are cited by Ravi Kumar [893]. 

Deshpande PP, Danishefsky SJ. Total synthesis of the potential anti cancer vaccine KH-1 adenocarcinoma antigen. Nature 1997 387 164-166. 

Lewis y epitope Anti-cancer Lewis y clustering vaccine Memorial Sloan-Kettering Cancer Center... 

A recently published fast-DC protocol, stimulating monocytes for only 2 days ex vivo in the presence of IFN-y and lipopolysaccharide (LPS), reported tumour-peptide-specific responses (to Her/2b) and decreased tumour volumes in vaccinated breast cancer patients [47], the mechanism being dependent on a delayed IL-12 burst. Alternatively, maturation can be induced in vivo following administration of the antigen-loaded DC with systemically applied antibodies cross-linking stimulatory molecules on DC, such as anti-CD40 antibody [48]. 

As with other health-related conditions, prevention beats intervention. The ultimate objective shared by all of us is stopping cancer from occurring in the first place through adequate screening, development of anti-cancer vaccinations, and healthful lifestyle choices. And what is plan B for those cases we cannot prevent To treat patients with therapies that make them well without harming the health and functioning of their brains and other normal tissues. 

Papilloma virus vaccine (HPV) cancer viral origin) Anti-cervical cancer vaccine 1980 2006 0.60") ... 

Therapeutic glycoprotein hormone gonadotropins and anti-cancer multivalent constructs are documented in Chapters 22 and 23, respectively, while the field of carbohydrate-based vaccines is covered in the next three chapters, focusing on anti-cancer vaccines (Chapters 24 and 25), and antibacterial and antifungal vaccines (Chapter 26). 

Le> -mucin bearing cells. Clinical evaluation of an anti-cancer vaccine based on 106 is currently well underway. 

Not only have encouraging results been obtained with models of vims infection such as the influenza vims system but they have also been reported in several cancer models The destmetion of cancer cells is often dependent on a vigorous CTL response and there is every reason to believe that efficient delivery of tumour-specific CTL epitopes could provide off the shelf cancer vaccines. A realisation of the central role that dendritic cells play in the efficient presentation of antigen to the immune system is nowhere more evident than with the development of anti-cancer vaccines and it is possible that successes in this area could provide a momentum which will benefit peptide vaccines in general. 

Belagen pu matucel-L Anti-TGF-(32 vaccine TGF- 32 Nonsmall-cell lung cancer... 

LaTemple, D.C., Abrams, J.T., Zhang, S.Y. et al. (1999) Increased immunogenicity of tumor vaccines complexed with anti-Gal studies in knockout mice for a 1,3galactosyltransferase. Cancer Research, 59 (14), 3417-3423. 

Yamaguchi S, Tatsumi T, Takehara T et al (2010) EphA2-derived peptide vaccine with amphiphilic poly(gamma-glutamic acid) nanoparticles elicits an anti-tumor effect against mouse liver tumor. Cancer Immunol Immunother 59 759-767... 

Hamdy S, Molavi O, Ma Z et al (2008) Co-delivery of cancer-associated antigen and Toll-like receptor 4 ligand in PLGA nanoparticles induces potent CD8+ T cell-mediated anti-tumor immunity. Vaccine 26 5046-5057... 

The most widely studied therapeutic proteins produced in plants include monoclonal antibodies for passive immunotherapy and antigens for use as oral vaccines [40]. Antibodies against dental caries, rheumatoid arthritis, cholera, E. coli diarrhea, malaria, certain cancers, Norwalk virus, HIV, rhinovirus, influenza, hepatitis B virus and herpes simplex virus have been produced in transgenic plants. However, the anti-Streptococcus mutans secretory antibody for the prevention of dental caries is the only plant-derived antibody currently in Phase II clinical trials [40]. Until recently, most antibodies were expressed in tobacco, potato, alfalfa, soybean, rice and wheat [9], It has been estimated that for every 170 tons of harvested tobacco, 100 tons represents harvested leaves. A single hectare could thus yield 50 kg of secretory IgA [3, 41]. Furthermore, it has been estimated that the cost of antibody production in plants is half that in transgenic animals and 20 times lower than in mammalian cell cul-... 

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