Animals transgenic

The production of heterologous proteins in transgenic animals has gained much attention in the recent past. The generation of transgenic animals is most often undertaken by directly microinject-ing exogenous DNA into an egg cell. In some instances, this DNA will be stably integrated into 

Protein Animal species Expression level in milk (mg 1 ) 

A number of additional general characteristics may be cited that render attractive the production of pharmaceutical proteins in the milk of transgenic farm animals. These include  

Species Annual milk yield (1) Time to first production batch (months) 

Despite the attractiveness of this system, a number of issues remain to be resolved before it is 

Protein Animal species Expression levels in milk 

Another general disadvantage of this approach relates to the use of the micro-injection technique to introduce the desired gene into the pronucleus of the fertilized egg. This approach 

Protein Caseins /1-Lactoglobulin ot-Lactalbumin Serum albumin IgG 

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Biotechnology is being appHed in the dairy industry. A significant and controversial development is the technique of producing transgenic animals, ie, animals in which hereditary deoxyribonucleic acid (DNA) has been augmented by DNA from another source, using recombinant DNA (rDNA) techniques. 

Transgenic animal models with spontaneous or induced receptor gene defects have been instrumental in elucidating the physiological roles of the LDL receptor gene family. In addition, a number of human diseases have been identified that are caused by sporadic or inherited forms of receptor deficiency (Table 1). 

Transgenic animals are genetically engineered animals, which allow the functional assessment of specific genes or proteins in health and disease. 

Transgenic Animal Models Transient Receptor Potential Transition State Translation Inhibitors Translocon... 

Chimeric DNA molecules are introduced into cells to make transfected cells or into the fertilized oocyte to make transgenic animals. 

An attempt to organize information on transgenic animals and targeted mutations generated and analyzed worldwide.)... 

In each of these studies dozens of transgenic animals were made and characterized. This is necessary because there is considerable individual variability in phenotype, presumably because of different sized transgene concatemers and different chromosomal integration sites. In some foun-... 

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