Type-Compound-Method Index

The Type-Compound-Method Index includes all compounds in this book and a few in the previous books [3] and [4] and in the literature. 

The indexes of the first edition have been replaced by a type-compound-method index. 

The design methods considered for multicomponent mixtures in Chap. 9 were based on a limited number of definitely known components. In some cases, the mixtures are so complex that the composition with reference to the pure component is not known. This is particularly true of the petroleum naphthas and oils which are mixtures of many series of hydrocarbons, many of the substances present having boiling points so close together that it is practically impossible to separate them into the pure components by fractional distillation or any other means. Even if it were possible to determine the composition of the mixture exactly, there are so many components present that the methods of Chap. 9 would be too laborious. It has become customary to characterize such mixtures by methods other than the amount of the individual components they contain, such as simple distillation or true-boiling-point curves, density, aromaticity (or some other factor related to types of compounds), refractive index, etc. 

Coordinate Indexing and Boolean Logic. Three methods of indexing have been prominent in the chemical Hterature in recent times. The first, articulated indexing, has been used in printed Chemicaly hstracts subject indexes from their earliest days until well into the 1990s. A number of important concepts are identified as permissible index entries, including specific compounds, material types, reactions, and processes. One or more modifying statements foUow each basic index entry. Thus, eg. 

Pure, low temperature organic Hquid viscosities can be estimated by a group contribution method (7) and a method combining aspects of group contribution and coimectivity indexes theories (222). Caution is recommended in the use of these methods because the calculated absolute errors are as high as 100% for individual species in a 150-compound, 10-family test set (223). A new method based on a second-order fit of Benson-type groups with numerous steric correctors is suggested as an alternative. Lower errors are claimed for the same test set. 

The subject index provides access to the text by way of methods, techniques, reaction types, apparatus, effects and other phenomena. Also, it lists compound classes such as organotin compounds or rare-earth hydrides which cannot be expressed by the empirical formulas of the compound index. 

This index is divided into two parts. Part 1 gives the names of compounds as used in these volumes as well as general terms for classes of compounds, types of reactions, synthetic applications, special apparatus, and unfamiliar methods. The complete names of all specific compounds are given in normal order as written in the text (e.g., ethyl cyano-acetate appears under ethyl). Some entries are common names and others are systematic Chemical Abstracts names, whichever was used in the text. 

The index lists the names of compounds in two forms. The first is the name used commonly in procedures. The second is the systematic name according to Chemical Abstracts nomenclature, accompanied by its registry number in brackets. While the systematic name is indexed separately, it also accompanies the common name. Also included are general terms for classes of compounds, types of reactions, special apparatus, and unfamiliar methods. 

Entries in capital letters in Part I and Part II indicate compounds in the title of a preparation Entries in ordinary type letters refer to principal products and major by products, special reagents or intermediates (which may or may not be isolated), compounds mentioned in the text, Notes or Discussion as having been prepared by the method given, and apparatus described in detail or illustrated by a figure. Numbers in boldface type denote the volumes Numbers in ordinary type indicate pages on which a compound or subject is mentioned in the indicated volume Compounds in the Tables given by formula only may not be indexed... 

Method C makes use of a so called dispersion analyzer, which is a particular form of stylus type surface roughness meter. The principle is that the worse the dispersion the rougher the surface. A dispersion index is obtained from the number of peaks/cm and average height of peaks measured, plus material constants obtained by method B. The object appears to be to use the analyzer as a convenient routine control method after the compound has been evaluated by the more tedious method B. 

There are many types of HPLC detectors available today with the most popular ones including UV and UV-photodiode array (PDA), fluorescence, refractive index, evaporative light scattering (ELSD), charged aerosol (CAD), and the mass spectrometer. Of these, the most commonly used detector for pharmaceutical analytical methods is the UV detector since a majority of pharmaceutical compounds have some type of chromophore. Multiple detectors in series can also be utilized in order to obtain more information per chromatographic run. For example, a PDA detector can... 

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