First Edition

Ciassicai thermodynamics with many appiications and much experimentai information. Tabies and graphs. Resuits of statisticai mechanicai caicuiations. The first edition (1923) was the first reai presentation of thermodynamics for chemists. 

Chu B 1991 Laser Light Scattering, Basic Principies and Practice 2nd edn (New York Academic) (See also the first edition (published in 1974) that contains more mathematical derivations.)... 

Readers interested in medicinal chemistry can obtain an excellent overview ft om the book The Practice of Medicinal Chemistry, edited by Wermuth [1]. The first edition is nicknamed The Green Bible by medicinal chemists. "The Red Bible written by Bbhm, Klebe, and Kubinyi describes the development of new drugs [2]. An overview of different classes of drugs and their mechanisms of action is given by Mutschler [3]. 

Assistance with the illustrations for the second edition was provided by Drs R Groot, S McGrother and V Milman. Many of the figures from the first edition are also included here and so 1 would like to thank again Dr S E Greasley, Dr M M Harm, Dr H Jhoti, Dr S N Jordan, Professor G R Luckhurst, Dr P M McMeekin, Dr A Nicholls, Dr P Popelier, Dr A Robinson and Dr T E Klein. 

In the first edition of this book I wrote, A major use of the Internet is for electronic mail, but extremely rapid growth is being observed in other areas, particularly the "World-Wide Web" (WWW).... Such a phrase seems an understatement despite the hype, the Internet has certainly made a dramatic impact, not least on the scientific community, where its... 

A second edition always needs an excuse, particularly if it follows hard upon the first. I take the obvious one a lot has happened in microcomputational chemistry in the last five years. Faster machines and better software have brought more than convenience there are projects in this book that we simply could not do at the time of the first edition. 

After Strike wrote the first edition and started up the old web site, a lot of new theories came in. The most promising was a proposition from our founding father of cyber chemistry Eleusis. This was his proposal ... 

Strike ranked it 3 in the Top Ten from the first edition because Strike didn t think people would bite at the idea of using such an expensive catalyst as PdCl2. Street chemists are often tightassed when that is the last thing they should be when it comes to production. But this has not been the case with this procedure as Strike has happily found out. At 7.00- 9.00/g, PdCb is still pretty pricey but this has not been a deterrent as many chemists have found. Nor should it be. This procedure works so well that it would, in fact, be stupid not to do it should one happen to work in an accredited, licensed research lab. The following is what Strike first wrote about it. 

METHOD 5 Could something this easy really work Actually, yesi Well, ya wanna know something Actually Strike doesn t know if this really works or not (We ll discuss this in a bit. But first read the following which was what Strike wrote in the first edition of TS). Safrole is converted to MD-P-2-P in about 8 hours with no watched chemicals and a yield of 70%-80% [19]. The reaction is shown in the accompanying diagram. 

What you have just read is what Strike wrote in the first edition. Strike laid down one day just before publishing and had this bad ass premonition regarding the recipe. But most people since then have not. Let s see what the problem is. 

When Strike wrote the first edition Strike considered there to be only one, decent reduction method for the p-Nitropropene. But since then Strike has come across quite a few new ways that make this conversion very, very easy and varied. A lot of the ways were conjured up by one, industrious lab from Tennessee. We ll get to those in a minute. But first let s start off with the basic, default recipe for the reduction of p-Nitropropenes. 

These last three theoretical methods have no real kinship to any of the major categories or precursors. The first is the one that has caused Strike more despair than any other. It was once a Top Ten recipe in the first edition. But it was a reckless gamble on Strike s part and Strike paid for it. Here is what Strike wrote last year... 

And wouldn t you know it.someone already has. Without a doubt Strike is most proud of the new testimonials that have been placed in this section for this edition. Strike had little faith that someone would actually apply the (legal) recipes here from the first edition, but one person named Merlin did Not only is Merlin the handsomest chemist around (seen a picture) but she/he has provided some experimentals for which every one of you ingrates will be thankful for years to come. Maybe not now. But someday soon. 

In order to continue to make heterocyclic chemistry as readily accessible as possible, new editions are planned for those areas where the respective volumes in the first edition have become obsolete by overwhelming progress. If, however, the changes are not too great so that the first editions can be brought up-to-date by supplementary volumes, supplements to the respective volumes will be published in the first editions. 

The principal aim of the second edition of this book remains the same as that of the first edition to give a critical exposition of the use of the adsorption methods for the assessment of the surface area and pore size distribution of finely divided and porous solids. 

A vast amount of research has been undertaken on adsorption phenomena and the nature of solid surfaces over the fifteen years since the first edition was published, but for the most part this work has resulted in the refinement of existing theoretical principles and experimental procedures rather than in the formulation of entirely new concepts. In spite of the acknowledged weakness of its theoretical foundations, the Brunauer-Emmett-Teller (BET) method still remains the most widely used procedure for the determination of surface area similarly, methods based on the Kelvin equation are still generally applied for the computation of mesopore size distribution from gas adsorption data. However, the more recent studies, especially those carried out on well defined surfaces, have led to a clearer understanding of the scope and limitations of these methods furthermore, the growing awareness of the importance of molecular sieve carbons and zeolites has generated considerable interest in the properties of microporous solids and the mechanism of micropore filling. 

The incorporation of the new material without any increase in the overall length of the book has been achieved in part by extensive re-writing, with the compression of earlier material, and in part by restricting the scope to the physical adsorption of gases (apart from a section on mercury porosimetry). The topics of chemisorption and adsorption from solution, both of which were dealt with in some detail in the first edition, have been omitted chemisorption processes are obviously dependent on the chemical nature of the surface and therefore cannot be relied upon for the determination of the total surface area and methods based on adsorption from solution have not been developed, as was once hoped, into routine procedures for surface area determination. Likewise omitted, on grounds of... 

NationalEnerg) Strategy, First Edition 1991 /1992 Department of Energy, Washington, D.C., Eeb. 1991. 

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