Polycythemia rubra vera

Polycythemia is usually defined as a hematocrit above 0.50 in males and 0.47 in females. Polycythemia rubra vera or primary polycythemia, a myeloproliferative disorder, may be complicated by TIAs, ischemic stroke or intracranial venous thrombosis (Silverstein et at 1962 Pearson and Wetherley-Mein 1978 Markus and Hambley 1998). Ischemic complications may occur because the platelet count is raised and platelet activity enhanced, or... 

Essential thrombocythemia, or idiopathic primary thrombocytosis, is another myeloproliferative disorder in which the platelet count is raised, usually to over 1000 x lO cells/1. Secondary thrombocytosis occurs in malignancy, splenectomy, hyposplenism, surgery, trauma, hemorrhage, iron deficiency, infections, polycythemia rubra vera, myelofibrosis and the leukemias. There is a tendency for arterial and venous thrombosis and, paradoxically, intracranial hemorrhage because the platelets are hemostatically defective (ArboLx et al. 1995 Harrison et al 1998 Mosso et al. 2004 Ogata et al 2005). 

A 70-year-old woman with polycythemia rubra vera and Guillain-Barre syndrome, but no known risk factors for thrombosis, had a cerebral infarction 10 days after receiving intravenous immunoglobulin the authors wondered whether there was a relation to the polycythemia vera (48). 

Polycythemia rubra vera Renal vascular disorders Severe anoxia Snake bite Solid tumors Transplant rejection... 

Essential thrombocytosis/ polycythemia rubra vera TIMP-1 Serum/High... 

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