Inhibition ratio

Anti-edema activity. Methanol extract of the root, applied externally to mice at a dose of 2 mg/ear, produced inhibition ratio of Anti-estrogenic effect. Ethanol (95%) extract of the dried seed, administered by gastric intubation of ovariectomized mice at a dose of 40 mg/kg daily for 3 days, produced weak activity° h Petroleum ether extract of the dried seed, at a dose of 10 mg/kg, was active° k... 

Anti-edema activity. Methanol extract of the rhizome, applied topically to mice at a dose of 2 mg/ear, was active vs 12-0-tetradecanoyl-13-acetate-induced ear inflammation. The inhibition ratio was nine " . 

Various lipid fractions (800 mg/kg) were orally administered for 20 day in sarcoma 180-bearing mice. Inhibition ratio (%) was measured as tumor volume or tumor weight of various lipid fraction-treated mice/ tumor volume or tumor weights of control mice. Each value represents the means S.E. of 10 mice. P<0.05, Significantly different from sarcoma 180-bearing mice. 

An estimate of the amount of pesticide the SPCE has been exposed to in molar diazinon equivalents can be found as follows a calibration curve can be obtained by plotting the degree of inhibition (ratios of electrode responses) against the concentration of pesticide standard. Fit a curve to the data and estimate the amount of pesticide in the wool extracts from the ratios for the electrodes exposed to wool extracts. As the standard used was diazinon, this will only give the pesticide concentration in diazinon equivalents. 

Inspection of Eq. (5.29) reveals that there are two quantities besides R that control the degree of conversion x at a particular point in time, the saturation ratio [S0]/KM and the inhibition ratio Xm/Kj. Figures 5.2-5.4 elucidate the importance of both ratios. 

Inhibition ratio. The inhibition ratio JCm/K] is particularly important as it is totally outside the control of the researcher or operator. Figures 5.2-5.4 demonstrate that an inhibition ratio Km/JC] < 1 is not detrimental the substrate binds more tightly than the inhibitor and the high degrees of conversion can still be achieved with out much difficulty, maybe at longer reaction times. If 2CM/2C > 1, however, the reaction crawls to a virtual stop at intermediate degrees of conversion and the reaction will not reach completion. 

Figure 5.3 Time (in units of [S0]/vmax) as function of the extent of reaction (degree of conversion x) for competitive, noncompetitive (R = 1), and mixed (R = 0.15) product inhibition the value of the inhibition ratio /CM//C is 0.1 (L. G. Lee, 1986).

Key i.c., intracutaneous i.p., intraperitoneal i.v., intravenous. Lipopolysaccharide was injected either daily for seven days, or for three days on days 2, 4, and 6 after tumor inoculation. Mice used were dd/Y (inbred strain). Tumors were removed and weighed on the 14th day after implantation. Inhibition ratio (%) was calculated on the basis of the tumor weight given by the authors. 

Glucan Source Linkages Dose (mg/kg x number) Route of injection Complete regression Inhibition ratio (%)... 

COMPAMSON OF SUBSTRATE RaTIOS AND INHIBITION RATIOS FOR HoRSE ErYTHBOCYTE ACETYLCHOLINESTEBASE (AChE) AND HoRSE PlaSMA... 

In %. Tumor inhibition ratio (C - T)/C x 100 (C - tumor weight of control mice, T tumor weight in lentinan treated mice. 

Polysaccharide Source Linkage Dose (mg/kg X 10) Inhibition ratio (%) References... 

Polysaccharides were administered i.p. daily for 10 days, starting 24 h after tumor transplantation and the inhibition ratios of tumor-growth were calculated after 5 weeks. ... 

Tumor mice Dose mg/kg x day Inhibition ratio (% References... 

As shown in Fig. 6, DE-310 induced far less myelotoxicity than DX-895 If at doses giving similar degrees of antitumor effect with inhibition ratios (IR) over 90%. 

Ascites sarcoma 180 cells (10 ) were implanted in the armpit of ICR-JCL mice. The polysaccharide solution, with a concentration of 1-10 mg/kg mouse, was injected intraperitoneally for ten days, starting 24 hr after the im.plantation of the ascites tumor. All mice were kept under observation for 5 weeks and then sacrificed for the evaluation of the effect of the treatment on the tumor growth. The inhibition ratios were calculated by the following equation, where A is the average tumor weight of the control groups and B is that of the treated groups. 

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