Vascular tumor

Nibbs RJ, Kriehuber E, Ponath PD, et al. The beta-chemokine receptor D6 is expressed by lymphatic endothelium and a subset of vascular tumors. Am J Pathol 2001 158(3) 867-77. 

CD31 (54), Factor Vlll-related antigen (55), and CD34 (56) cannot often be demonstrated in poorly differentiated vascular tumors. The use of the lectin Ulex europaeus agglutinin 1 (UEA-1) (57) is a more sensitive method to detect endothelial cells. Like other lectins, however, UFA-1 reacts with many other cell types. 

No increase in tumor incidence was seen in rats fed up to 1000 ppm in the diet for 2 years in mice, results were equivocal, with high-dose animals showing an increase in vascular tumors and low-dose males showing an increase in liver tumors. The lARC has determined that there is inadequate evidence in experimental animals and humans for the carcinogenicity of chlorobenzenes. ... 

Vascular tumors in female Swiss mice after intraperitoneal injection of dimethylni-trosamine. J Natl Cancer Inst 51 201-205, 1973... 

Lipids A are generally considered to act through TNF-a secretion [112], For instance ONO-4007 was shown to be efficient only on TNF-a-sensitive tumors [171,172], therefore, only well vascularized tumors can be affected. However, in our model, we showed that TNF-a is probably not involved since this cytokine peakes after the first two injections and then returns to basal levels before tumor regression. The efficacy of OM-174 relies on an indirect induction of an autotoxic production of NO by the tumor cells [104], Perhaps a more important aspect is the immunogenicity of tumor cells. After apoptosis or necrosis of tumor... 

Spinal subarachnoid hemorrhage is very rare. It is caused by a vascular malformation, hemostatic failure, coarctation of the aorta, inflammatory vascular disease, mycotic aneurysm or a vascular tumor such as ependymoma. Accumulating hematoma may compress the spinal cord. Suspicion is aroused if the cerebral angiogram is negative and the patient develops spinal cord signs. 

Kuzu, L, Bicknell, R., Harris, A. L., Jones, M., Gatter, K. C. and Mason, D. Y. (1992). Heterogeneity of vascular endothelial cells with relevance to diagnosis of vascular tumors. J. Clin. Pathol. 45, 143-148. 

Yonezawa S, Maruyama I, Sakae K, et al. Thrombomodulin as a marker for vascular tumors Comparative study with factor VIII and Ulex europaeus I lectin. Am J Clin Pathol. 1987 88 405-411. 

Folpe AL, Veikkola T, Valtola R, et al. Vascular endothelial growth factor receptor-3 (VEGFR3) A marker of vascular tumors with presumed lymphatic differentiation, including Kaposi s sarcoma, kaposiform and Dabska-type hemangioendotheliomas, and a subset of angiosarcomas. Mod Pathol. 2000 13 180-185. 

Vascular tumors Adults. Soft tissue and various visceral organs. Angiosarcoma epithelioid and spindle cell tumor, vasoformative areas epithelioid in hemangioendothelioma FVIII+, CD31+, CD34+, FLI1+, thrombomodulin+, patchy keratin+ EM to identify endothelial cells rarely required... 

Lin BT-Y, Colby T, Gown AM, et al. Malignant vascular tumors of the serous membranes mimicking mesothelioma A report of 14 cases. Am J Surg Pathol. 1996 20 1431-1439. 

Perhaps because of the wide spectrum of morphologic images associated with vascular tumors of the skin, a great deal of attention has been paid to their immuno-... 

The usual approach to characterization of a vascular tumor is to employ a battery of endothelial-selective markers together with several reagents directed at epithelial and muscle-related determinants. That is because selected endothelial tumors may histologically simulate carcinomas or sarcomas with myogenic differentiation... 

As mentioned earlier, the distinction between EPS and ESLH principally relies on a demonstration of specific endothelial markers in the latter of those neoplasms. CD31 and FLI-1 are the most discriminatory. In fact, the same rule applies to the diagnostic separation between all vascular tumors and EPS. 

O Hara CD, Nascimento AG. Endothelial lesions of soft tissues a review of reactive and neoplastic entities with emphasis on low-grade malignant (borderline) vascular tumors. Adv Anat Pathol. 2003 10 69-87. 

Miettinen M, Fetsch JF. Distribution of keratins in normal endothelial cells and a spectrum of vascular tumors implications in tumor diagnosis. Hum Pathol. 2000 31 1062-1067. 

The FLI-1 protein is overexpressed in EWS/PNETs, which contain the EWS-FLIl/1 fusion gene, owing to the translocation t(ll 22)(q24 ql2). Nuclear FLI-1 immunoreactivity is found in approximately 70% of EWS/PNET but is also observed in nearly 90% of lymphoblastic lymphomas and in vascular tumors. TTs This antibody is useful as part of a panel for evaluation of potential EWS/PNET, when the overlap with lymphoblastic lymphomas and vascular neoplasms is considered. 

Miettinen M, Lindenmayer AE, Chaubal A. Endothelial cell markers CD31, CD34, and BNH9 antibody to H- and Y-anti-gens—Evaluation of their specificity and sensitivity in the diagnosis of vascular tumors and comparison with von Willebrand factor. Mod Pathol. 1994 7 82-90. 

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