Transformation growth factors

S. Increased synthesis of transforming growth factor-beta , which blocks cell division and promote.s apoptosis by interacting with its own membrane recepror,... [Pg.285]

Receptor Serine/Threonine Receptor Kinase Transforming Growth Factor- 3 Superfamily... [Pg.14]

Transforming Growth Factor-Beta Ubiquitin/Proteasome... [Pg.455]

Bottner M, Krieglstein K, Unsicker K (2000) The transforming growth factor-(3s structure, signaling, and roles in nervous system development and functions. J Neurochem 75 2227-2240... [Pg.845]

In the interstitium, angiotensin II induces proliferation of mesangial cells and fibroblasts and the synthesis of collagen and other matrix molecules by these cells via the ATI receptor. Moreover, by the concomitant stimulation of chemoattractant cytokines, inflammation is induced. These processes are mediated by endothelin, transforming growth factor(3, and reactive oxygen species, and finally lead to interstitial fibrosis and glomerulosclerosis observed in hypertension and diabetes. [Pg.1067]

Hyperphosphorylation of ERAK-1 by itself and ERAK-4 causes ERAK-1 to dissociate from the membrane-bound complex. Tumour necrosis factor (TNF) receptor-associated factor-6 ( TRAF-6), a cytoplasmic protein, is activated by ERAK-1 and with TAB-2, another cytoplasmic protein, activates transforming growth factor-P (TFG-P)-activating kinase (TAK-1). During this process both TRAF-6 and TAK-1 become ubiquitinated. TAK-1 then promotes activation of the IkB kinases, or the IKK family, EKKa and EKK 3 (found in a complex with NFicB-essential modulator [NEMO]), which phosphorylate the IkB family, notably IkB-u. IkB-u is an inhibitor of NFkB as it sequesters NFkB in an... [Pg.1208]

Transforming growth factor-beta recqrtor signaling pathway TGF-beta recqrtor signaling pathway TGF-(3 recqrtor signaling pathway... [Pg.1229]

Transforming growth factor-beta (TGF- 3) proteins are multifunctional morphogens that control cell proliferation, differentiation and apoptosis, as well as cell migration and immune surveillance. TGF-(3 acts as a tumor suppressor, but can also act as a tumor promoter in... [Pg.1229]

Transforming Growth Factor-Beta. Table 1 Agents that target the TGF-(3 signaling pathway... [Pg.1232]

Danielpour D (2005) Functions and regulation of transforming growth factor-beta (TGF-beta) in the prostate. Eur J Cancer 41 846-857... [Pg.1233]

Mishra L, Derynck R, Mishra B (2005) Transforming growth factor-beta signaling in stem cells and cancer. Science 310 68-71... [Pg.1233]

Faler BJ, Macsata RA, Plummer D et al (2006) Transforming growth factor-beta and wound healing. Perspect Vase Surg Endovasc Ther 18(1) 55—62... [Pg.1233]

Transforming Growth Factor-Beta Transforming Oncogenes Transgene... [Pg.1504]

Big Chemical Encyclopedia

Chemical substances, components, reactions, process design ...