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Transforming growth factor a TGFa

Transforming growth factor-a-Pseudomonas aeruginosa exotoxin A 40 (TGFa-PE40, Mr = 44,960) is a recombinant fusion protein synthesized in E. co/z.127,128 The growth factor moiety binds to surface epidermal growth factor (EGF) receptors on cancerous cells and is internalized where it releases the exotoxin domain into the cytosol.128 The toxin subunit catalytically inactivates the protein synthesis machinery of the cancer cell and the cell subsequently dies.129 It is a recombinant protein intended to be an anticancer therapeutic. [Pg.60]

BBB blood-brain barrier TGFa transforming growth factor a... [Pg.1271]

See other pages where Transforming growth factor a TGFa is mentioned: [Pg.481]    [Pg.158]    [Pg.252]    [Pg.106]    [Pg.103]    [Pg.578]    [Pg.648]    [Pg.129]    [Pg.359]    [Pg.5]    [Pg.547]    [Pg.43]    [Pg.481]    [Pg.158]    [Pg.252]    [Pg.106]    [Pg.103]    [Pg.578]    [Pg.648]    [Pg.129]    [Pg.359]    [Pg.5]    [Pg.547]    [Pg.43]    [Pg.85]    [Pg.569]    [Pg.4]    [Pg.646]    [Pg.1280]    [Pg.180]    [Pg.323]    [Pg.250]    [Pg.156]    [Pg.156]    [Pg.42]    [Pg.508]   
See also in sourсe #XX -- [ Pg.103 ]



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As a growth factor

Transformation growth factors

Transforming growth factors

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