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Tandem mass spectrometry applications

MS/MS applications are plentiful, for example in elucidation of structure, determination of fragmentation mechanisms, determination of elementary compositions, applications to high-selectivity and high-sensitivity analysis, observation of ion-molecule reactions and thermochemical data determination (kinetic method). We will examine them in detail through a few examples. [Pg.204]

Raices R.S.L. et al., 2003. Determination of stavudine in human serum by online solid-phase extraction coupled to high-performance liquid chromatography with electrospray ionization tandem mass spectrometry Application to a bioequivalence study. Rapid Commun Mass Spectrom 17 1611. [Pg.296]

Mass separator, 74 443 Mass spectrometer, 75 647-648, 650-665 Mass spectrometry (ms, MS), 75 647-670. See also Tandem mass spectrometry applications of, 75 666-669 archaeological materials, 5 743 biochemical, 75 666-668 concepts and definitions related to, 75 647-650... [Pg.553]

Figure 25-8 Baseline separation of enantiomers of the drug Ritalin by HPLC with a chiral stationary phase. One enantiomer is pharmacologically active for treating attention deficit disorder and narcolepsy. The other enantiomer has little activity but could contribute to undesired side effects. Pharmaceutical companies are moving toward providing enantiomerically pure drugs, which could be safer than mixtures of optical isomers. [From R. Bakhtiar, L Ramos, and F. L. S. Tse, "Quantification of Methylphenidate in Plasma Using Chiral Uquid-Chromatography/Tandem Mass Spectrometry Application to Taxicokinetic Studies," Anal. Chim. Acta 2002, 469.261.]... Figure 25-8 Baseline separation of enantiomers of the drug Ritalin by HPLC with a chiral stationary phase. One enantiomer is pharmacologically active for treating attention deficit disorder and narcolepsy. The other enantiomer has little activity but could contribute to undesired side effects. Pharmaceutical companies are moving toward providing enantiomerically pure drugs, which could be safer than mixtures of optical isomers. [From R. Bakhtiar, L Ramos, and F. L. S. Tse, "Quantification of Methylphenidate in Plasma Using Chiral Uquid-Chromatography/Tandem Mass Spectrometry Application to Taxicokinetic Studies," Anal. Chim. Acta 2002, 469.261.]...
Z. Xie, Q. Liao, X. Xu, M. Yao, J. Wan, D. Liu, Rapid and sensitive determination of donepezil in human plasma by liquid chromatography/tandem mass spectrometry application to a pharmacokinetic study, Rapid Commun. Mass Spectrom. 20 (2006) 3193-3198. [Pg.149]

Kushnir MM, Rockwood AL, Bergquist J (2010) Liquid chromatography-tandem mass spectrometry applications in endocrinology. Mass Spectrom Rev 29 480-502... [Pg.123]

Shi BS, Yoo SD (2007) Determination of clopidogrel in human plasma by liquid chromatog-raphy/tandem mass spectrometry application to a clinical pharmacokinetic study. Biomed... [Pg.140]

Wang, X.-D., Li, J.-L., Lu, Y., Chen, X., Fluang, M., Chowbay, B., Zhou, S.-F. Rapid and simultaneous determination of nifedipine and dehydronifedipine in human plasma by liquid chromatography-tandem mass spectrometry Application to a clinical herb-drug interaction study. J. Chromatogr. B 852, 534—544 (2007)... [Pg.279]

S. Itoh, N. Kawasaki, M. Ohta, T. Hayakawa, Structural analysis of a glycoprotein by liquid chromatography-mass spectrometry and liquid chromatography with tandem mass spectrometry Application to recombinant human thrombomodulin, J. Chromatogr. A, 978 (2002)141. [Pg.543]

Vogeser M. Liquid chromatography-tandem mass spectrometry-application in the clinical laboratory. [Pg.163]

Linear Ion Trap (2D)/Hybrid Tandem Mass Spectrometry Applications... [Pg.180]

Abdel-Hamid, M.E., Sharaf, L.H., Kombian, S.B. and Diejomaoh, F.M.E. (2006) Determination of dydrogesterone in human plasma by tandem mass spectrometry application to therapeutic drug monitoring of dydrogesterone in gynecological disorders. Chromatographia, 64 (5/6), 287-292. [Pg.63]

Vajta, S. De Maack, F. Devant, G. Lesieur, M. Thermospray liquid chromatography tandem mass spectrometry application to the elucidation of zolpidem metabolism. Biomed.Environ. Mass.Spectrom., 1988, 15, 223-228... [Pg.1496]

Huck, J. H. Struys, E. A. Verhoeven, N. M. Jakobs, C. van der Knaap, M. S. Profiling of pentose phosphate pathway intermediates in blood spots by tandem mass spectrometry application to transaldolase deficiency. Clin. Chem. 2003, 49, 1375-1380. [Pg.28]

Sachon, E. Mohammed, S. Bache, N. Jenson, O.N. Phosphopeptide quantitation using amine-reactive tagging reagents and tandem mass spectrometry application to proteins isolated by gel electrophoresis. Rapid Commun. Mass. Spectrom. 2006, 20, 1127-1134. [Pg.116]

Tandem mass spectrometry (MS/MS) has attained an enviable status as an analytical tool to identify and quantify compounds in complex mixtures. MS/MS refers to the coupling of two stages of mass analysis, either in time or space. Of all the ionization techniques, only electron ionization (El) provides abundant sttuctural information. To obtain additional structure-specific information by other ionization techniques, it has become essential to perform MS/MS experiments [1,2]. MS/MS was first used in the late 1960s [3]. Since that time, its applications and popularity have continued to grow. Its major contributions are in the fields of structure elucidation of unknown compounds, identification of compounds in complex mixtures, elucidation of fragmentation pathways, and quantification of compounds in real-world samples. In recent times, several new generations of instruments have become available for tandem mass spectrometry applications. Basic concepts of tandem mass spectrometry and an account of these new developments are presented in this chapter. Additional reading material is listed at the end of the chapter. [Pg.119]

Becher F, Pruvost A, Clement G, Tabet JC, Ezan E. Quantification of small therapeutic proteins in plasma by liquid chromatography—tandem mass spectrometry Application to an elastase inhibitor EPI-hNE4. Anal Chem 2006 78(7) 2306—2313. [Pg.640]

Martin, P. Morden, W. Wall, P. Wilson, I. TLC combined with tandem mass spectrometry Application to the analysis for antipyrine and its metabolites in extracts of human urine. J. Planar Chromatogr.-Mod. TLC 1992, 5, 255-258. [Pg.2328]

Kim, K.B., Lee, D.I, Yeo, C.W., Shin, J.G., Bae, S.K. (2009) Simultaneous quantification of rosiglitazone and its two major metabolites, N-desmethyl and p-hydroxy rosigh-tazone in human plasma by liquid chromatography/ tandem mass spectrometry application to a pharmacokinetic study. Journal of Chromatography B. Analytical Technologies in the Biomedical and Life Sciences, 877, 1951-1956. [Pg.206]

Lafaye A, Junot C, Ramounet-Le Gall B, Fritsch P, Ezan E, Tabet JC. Profiling of sulfoconjugates in urine by using precursor ion and neutral loss scans in tandem mass spectrometry. Application to the investigation of heavy metal toxicity in rats. / Mass Spectrom. 2004 39(6) 655-664. [Pg.246]

Bootsma AH, Overmars H, van Rooj A, van Lint AE, Wanders RJ, van Gennip AH, et al. Rapid analysis of conjugated bile acids in plasma using electrospray tandem mass spectrometry application for selective screening of peroxisomal disorders. J. Inher. Metab. Dis. 1999 22(3) 307-10... [Pg.77]

Mater KM (2008) Quantification of levetirac-etam in hiunan plasma by liquid chromatography-tandem mass spectrometry application to therapeutic drug monitoring. J Pharm Biomed Anal48(3) 822-828... [Pg.210]

Tandem Mass Spectrometry Applications in FTMS 11.2 Magnetic Sector Mass Spectrometry... [Pg.366]

See other pages where Tandem mass spectrometry applications is mentioned: [Pg.204]    [Pg.205]    [Pg.207]    [Pg.209]    [Pg.211]    [Pg.137]    [Pg.68]    [Pg.45]    [Pg.674]    [Pg.127]    [Pg.399]   
See also in sourсe #XX -- [ Pg.381 ]

See also in sourсe #XX -- [ Pg.491 , Pg.492 , Pg.493 , Pg.494 , Pg.498 , Pg.500 ]



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