Herb-drug interactions

To what extent do environmental variables such as diet and substances have an influence in pharmacotherapy Can we minimize the adverse impact of drug-substance and drug-herb interactions ... 

Miller, L.G., Herbal medicinals Selected clinical considerations focusing on known or potential drug-herb interactions, Arch Intern Med, 158, 2200, 1998. 

Patients with cardiovascular disease (including hypertension), diabetes (risk of hyperglycemia), pregnancy (uterine contractions), prostatism, and anxiety disorders are among those who should not take ma huang at any dose. Drug-herb interactions occur with MAOIs (hypertensive crisis), phenoth-iazines (tachycardia, hypotension), (3-blockers (hypertension) and theophylline (increased CNS effects). Of course, caffeine and other stimulants have an additive effect. 

Brazier NC, Levine MA. Drug-herb interaction among commonly used conventional medicines a compendium for health care professionals. Am J Ther. 2003 10 163-169. 

Many dozens of herbal supplements are available to be purchased over-the-counter. Discussion of all these herbal supplements is beyond the scope of this article. Listed below is a brief discussion of each of the more commonly available and used supplements, including highlights of known active constituents, pharmacology, dosing, supporting clinical literature, adverse effects, and interactions with conventional medications. The known and potential drug-herb interactions are summarized in Table... 

Pennachio DL. Drug-herb interactions how vigilant should you be Patient Care 2000 19 41-68. 

Hoffman T. Ginko, Vioxx and excessive bleedii - possible drug-herb interactions case report. Hawaii Med J (2m) 60, 290. 

Information seems to be limited to these reports, but the interaction would appear to be established. The extent of the interaction may depend on the St John s wort preparation involved and dose used and seems to be correlated with the dose of hyperforin. See also Drug-herb interactions , (p.lO). Reductions in serum digoxin levels of the size seen with LI 160 could diminish the control of arrhythmias or heart failure. Digoxin serum levels should therefore be well monitored if St John s wort is either started or stopped and appropriate dosage adjustments made if necessary. The recommendation of the CSM in the UK is that St John s wort should not be used by patients taking digoxin. ... 

The mechanism for the increase in ciclosporin levels is unclear. Although the increase is not sufficiently severe to suggest that concurrent use should be avoided, it may make ciclosporin levels less stable and therefore be undesirable (see drug-herb interactions , (p.lO)). If concurrent use is undertaken it should be well monitored. 

D. auraria, 4094 D. melanogaster, 4096 Drought resistance, 1602 Drought stress, 2927 Drug(s), 978, 986, 990, 1002 abuse, 332, 334, 338,1030 bioavailability, 1400 development, 1640 resistant, 2214 susceptibility, 1295 Drug-herb interactions, 3969 Drummondita, 718 Dry distillation, 4090 Dryobalanops aromatica, 2984 DTC. See Denticin (DTC)... 

Yang XX, Hu ZP, Duan W, Zhu YZ, Zhou SF. Drug-herb interactions eliminating toxicity with hard drug design. CurrPharm Des. 2006 12 4649-64. 

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