Succinylcholine chloride

Molecular formula C14H30CI2N2O4 Molecular weight 361.31 CAS Registry No 71-27-2,55-94-7 (bromide), 541-19-5 (iodide) 

Sample preparation Condition a Bond Elut C2 SPE cartridge with 3 mL TMAH buffer and 3 mL water. Mix 1 mL plasma with 1 mL water and 100 rL 100 ng/mL IS in 100 mM pH 5.0 phosphate buffer, add to the SPE cartridge, wash with 3 mL water, wash with 3 mL MeCN, wash with 3 mL MeOH, elute with two 250 p,L portions of TMAH buffer, inject a 150 m-L aliquot of the eluate. (Prepare TMAH buffer by dissolving 275.6 mg tetramethylammonium chloride in 1 mL water and adding 240 mL MeOH, adjust to apparent pH 3.0 with 100 mM HCl, make up to 250 mL with MeOH.) 

Mobile phase MeCN MeOH 30 mM phosphoric acid 35 25 45, adjusted to apparent pH 5.00 with concentrated ammonium hydroxide 

Detector E, ESA Coulochem II, 5010 analytical cell, detector 1 450 mV (screen), detector 2 750 mV (monitored) 

Donati, P. Varin, P. Determination of succinylcholine in human plasma by high-performance liquid chromatography with electrochemical detection, J.Chromatogr.B, 1998, 718, 129-134. 

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Potential oscillation was measured in the presence of cholinergic agents (acetylcholine chloride, carbamylcholine chloride, carbamyl- d-methylcholine chloride, and acetyl-/6-methylcholine chloride) and anticholinergic agents (tetramethylammonium chloride, tetra-ethylammonium chloride, succinylcholine chloride, hexamethonium chloride, scopolamine hydrobromide, atropine sulfate, homatropine hydrochloride, and tubocurarine chloride)... 

FIG. 18 Chemical structures of (a) acetylcholine chloride, (b) carbamylcholine chloride, (c) carba-myl-y8-methylcholine chloride, (d) acetyl-/i-methylcholine chloride, (e) tetramethylammonium chloride, (f) tetraethylamonium chloride, (g) succinylcholine chloride, (h) hexamethonium chloride, (i) scopolamine hydrobromide, 0 atropine sulfate, (k) homatropine hydrochloride, and (1) tubocurar-ine chloride. 

SUCCINYLCHOLINE CHLORIDE INJECTION USP 100MG/ML 10ML VIAL25S 6505014716410 PG 69.42 ... 

SUCCINYLCHOLINE CHLORIDE INJECTION USP 20MG/ML 10ML VIAL 12/PG 6505014667167 PG 15.83 ... 

The effect of administering different botulinum neurotoxin serotypes at the same time or within several months of each other is unknown. Excessive neuromuscular weakness may be exacerbated by administration of another botulinum toxin prior to the resolution of the effects of a previously administered botulinum toxin. Aminoglycosides Cautiously perform coadministration of botulinum toxin type A and aminoglycosides or other agents interfering with neuromuscular transmission (eg, curare-like nondepolarizing blockers, lincosamides, polymyxins, quinidine, magnesium sulfate, anticholinesterases, succinylcholine chloride) because the effect of the toxin may be potentiated. 

Succinylcholine chloride (Anectine) is the only depolar-izing-type blocker that is in widespread clinical use. It produces neuromuscular block by overstimulation, so that the end plate is unable to respond to further stimulation. Structurally, succinylcholine is equivalent to two ACh molecules joined back to back. The resulting 10-carbon atom spacing between the two quaternary ammonium heads is important for activation of the two binding sites on the AChR. Because the succinylcholine molecule is thin, binding to the two sites does not ster-ically occlude the open channel, and cations are allowed to flow and depolarize the end plate. 

Blockade of neuromuscular transmission produced by an intravenous dose of d-tubocurarine chloride at 0.3 mg/kg, but not that due to 0.5 mg/kg, was antagonized by intravenous 2-PAM 1 at 5 mg/kg. Edrophonium bromide (intravenously at 0.2 mg/kg) was a more potent antagonist of d-tubocurarlne than this dose of 2-PAM 1. Partial blockades of neuromuscular transmission Induced by intravenous injections of decamethonium bromide at 20 Vg/kg, neostigmine bromide at 1 mg/kg, or succinylcholine chloride at 50 Mg/kg were intensified by Intravenous Injection of 2-PAM 1 at 5 mg/kg, in about the same way in which they were enhanced by intravenous doses of edrophonium bromide at 0.2 mg/kg. Intravenous doses of 2-PAM I at up to 150 mg/kg had no effect on the muscle response to direct stimulation in anesthetized cats. 

Succinylcholine chloride, hexamethonium bromide and decamethonium bromide were purchased from Sigma (St. Louis, MO). NPOE (2-nitrophenyloctyl ether)(Fluka) and poly(vinylchloride)(Aldrich)... 

Succinylcholine chloride (Anectine, Quelicin, Suxcert, Sucostrin)... 

Synonyms. Choline Chloride Succinate Succicurarium Chloride Succinylcholine Chloride. 

Styrene-divinylbenzene copolymers, 205 Subliniaze, 617 SubtilisinA, 1171 Succicurarium chloride, 998 Succinic acid, 999 Succinyl-Asta, 998 Succinylcholine bromide, 998 Succinylcholine chloride, 998... 

Succinylcholine Chloride. U5P. Succinylcholinc chloride. choline chloride succinate (2 1) (Attectinc. Sucostrin). is a white odorless crystalline. suKstance that is freely soluble in water to give solutions with a pH of about 4. It is stable... 

Succinylcholine chloride should not be used with thiopental. sodium because of the high alkalinity of the latter. If used together, they should be admini.siered immediately after mixing however, separate injection is preferable. 

Chole- Relating to the biliary system, cholestasis The failure of the normal bile flow to the intestine, causing cholestatic jaundice, cholinergic Nerve fibres that release ACETYLCHOLINE, cholinesterases Enzymes that hydrolyse choline esters, especially ACETYLCHOLINE of which there are two main forms acetylcholinesterase ( true cholinesterase ) is specific for acetylcholine, rapid in this action, and has a discrete distribution being especially located near cholinergic nerve terminals (and in erythrocytes) butyrylcholinesterase ( pseudo cholinesterase) is less selective and is able to hydrolyse some drugs (e.g. SUCCINYLCHOLINE CHLORIDE). Many drugs are known that inhibit the action of these enzymes. See anticholinesterases. chromatin A protein found in the nucleus which stains with basic dyes. It is used in the study of the behaviour of... 

T. Suzuki, Studies on decomposition and stabilization of drugs in solution. X. Chemical kinetic studies on aqueous solution of succinylcholine chloride. 2. Overall velocity constants for succinylcholine chloride hydrolysis as a function of pH, Chem. Pharm. Bull. 10, 912-921(1962). 

Methohexital (1 mg/kg in 1% solution given at a rate of 1 mL/5 seconds) is used for induction of anesthesia lasting 5 to 7 minutes. Maintenance of anesthesia may be accomplished by intermittent injections of 1% solution or by continuous IV drip of a 0.2% solution. Intermittent injections of about 20 to 40 mg (2 to 4 ml of a 1% solution) may be given as required, usually every 4 to 7 minutes. For continuous drip, the average rate of administration is about 3 mL of a 0.2% solution/min (1 drop/second). Methohexital should not be mixed in the same syringe or administered simultaneously during IV infusion through the same needle with acid solutions, such as atropine sulfate, metocurine iodide, and succinylcholine chloride. 

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