Homatropine hydrochloride

Potential oscillation was measured in the presence of cholinergic agents (acetylcholine chloride, carbamylcholine chloride, carbamyl- d-methylcholine chloride, and acetyl-/6-methylcholine chloride) and anticholinergic agents (tetramethylammonium chloride, tetra-ethylammonium chloride, succinylcholine chloride, hexamethonium chloride, scopolamine hydrobromide, atropine sulfate, homatropine hydrochloride, and tubocurarine chloride)... 

FIG. 18 Chemical structures of (a) acetylcholine chloride, (b) carbamylcholine chloride, (c) carba-myl-y8-methylcholine chloride, (d) acetyl-/i-methylcholine chloride, (e) tetramethylammonium chloride, (f) tetraethylamonium chloride, (g) succinylcholine chloride, (h) hexamethonium chloride, (i) scopolamine hydrobromide, 0 atropine sulfate, (k) homatropine hydrochloride, and (1) tubocurar-ine chloride. 

Phenylglycollyltropeine Mandelyltropeine, homatropine), CigHjiOjN. This is largely used as a substitute for atropine. It crystallises in prisms, m.p. 95-5-98-5°. The hydrobromide, the salt usually employed in medicine, is a crystalline powder, m.p. 217-8° (dec.) the hydrochloride, m.p. 224-5°, and the salicylate are also used. All tl ee are freely soluble in water. The methobromide has m.p. 192-6°. The aurichloride, B. HAUCI4, forms prisms and is sparingly soluble in water. Homatropine, unlike atropine, does not give the Vitali colour reaction (p. 70). Its mydriatic effect is more rapid and transient than that of atropine. 

D,L-Homatropine hydrobromide [51-56-9] Morphine sulfate [64-31-3] (55) Naloxone hydrochloride dihydrate [51481-60-8] 1882B I(2)286A, N(2)274C YM5602000, USP QC8750000, USP QD2275000, USP... 

Some of these agents are particularly useful in ophthalmology included in this category are homatropine hydrobromide (Isopto homatropine) (a semisynthetic derivative of atropine) cyclo-pentolate hydrochloride (Cyclogyl), and tropicamide (Mydriacyl). These agents are preferred to atropine or scopolamine because of their shorter duration of action. 

Homatropine Methobromide Oxyphenonium Bromide Phenacaine Hydrochloride Piperazine Citrate 190d Ascorbic Acid... 

Atropine sulfate Ipratropium bromide Mydriatic and Cyclopine Atropine sulfate Cyclopentolate hydrochloride Eucatropine hydrochloride Homatropine hydrobromide Scopolamine hydrobromide Tropicamide... 

Scopolamine produces the same effects in the eye as atropine, but is more powerful. It is usually administered as its hydrobromide, and a 0.2 % solution of this salt can be used instead of 1 % atropine. sulfate. The semisynthetic mandelic ester of tropine, homatropine, is useful as a transitory mydriatic. Both its mydriatic and cycloplegic effects are weaker than those of atropine and much shorter in duration. It is used as its hydrochloride or hydrobromide in 1-2 % solution. 

Ephedrine is a useful short-acting mydriatic when paralysis of accommodation is not required moreover, it does not produce an increase in intraocular pressure. Local application of a 3-5 % solution of the hydrochloride produces dilatation of the pupil within 30 to 60 min. which lasts for several hours. Since such solutions sometimes produce irritation, weaker solutions containing 0.1 % homatropine are frequently used to produce dilatation without cycloplegia. Ephedrine is apt to be ineffective in patients with dark-colored irides, e.g., in negroes (59a, 59b), and in certain eye conditions such as iritis (51). 

Eye-drops of Cocaine and Homatropine, B.P.C, Contain 1 per cent of cocaine hydrochloride and 2 per cent of homatropine hydrobromide. 

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