Anticholinergic agent

The manipulation of nondopaminergic neurotransmitters can also be used as disease specific therapy in PD. Anticholinergic agents, the first effective therapy for PD, having been pre- [Pg.568]

Conditions that are contraindications to the use of atropine and related drugs are glaucoma and prostatic hypertrophy, in which cases they cause urinary retention. [Pg.205]

Atropine toxicity is characterized by dry mouth, burning sensation in the mouth, rapid pulse, mydriasis, blurred vision, photophobia, dry and flushed skin, restlessness, and excitement. [Pg.205]

Physostigmine, given intravenously, counteracts both the peripheral and central side effects of atropine and other anticholinergic drugs such as thioridazine (neuroleptic), imipramine (antidepressant), and benztropine (antiparkinsonian medication). [Pg.205]

At this writing anticholinergic agents are not widely used for the symptomatic treatment of asthma, although compounds such as atropine [51 -55-8] C17H23NO3, (18) have been used for centuries (111). Inhalation of the smoke produced by burning herbal mixtures, such as Datura Stramonium provided bronchodilation and rehef from some of the symptoms of asthma. The major active component in these preparations was atropine or other closely related alkaloids (qv). [Pg.442]

Potential oscillation was measured in the presence of cholinergic agents (acetylcholine chloride, carbamylcholine chloride, carbamyl- d-methylcholine chloride, and acetyl-/6-methylcholine chloride) and anticholinergic agents (tetramethylammonium chloride, tetra-ethylammonium chloride, succinylcholine chloride, hexamethonium chloride, scopolamine hydrobromide, atropine sulfate, homatropine hydrochloride, and tubocurarine chloride)... [Pg.714]

Administer anticholinergic agent 1-2 min before acetylcholinesterase inhibitor... [Pg.81]

Anticholinergic agents (e.g., antihistamines, atropine, tricyclic antidepressants)... [Pg.87]

Anticholinergic agents should not be abruptly withdrawn but use may be a confounding variable in the setting of hyperthermia... [Pg.148]

Intranasal anticholinergic agents (e.g., ipratropium) reduce the severity and duration of rhinorrhea but have no effect on other nasal symptoms.11,12,21 Ipratropium reduces cholinergic hyperreactivity and cholinergically mediated histamine- and antigen-induced secretion. Intranasal ipratropium acts locally, with only minimal systemic absorption. Clinical trials demonstrated that ipratropium bromide 0.3% reduced rhinorrhea in adults and children with PAR.11,12 Intranasal ipratropium is an option for patients in whom rhinorrhea is refractory to topical intranasal corticosteroids and/or antihistamines.8,12 Intranasal ipratropium is available only by prescription, and the dose is two sprays nasally two to three times daily.15 Adverse effects are minimal, but dry nasal membranes have been reported.11,12... [Pg.931]

DIARYL AND ARYLALKYL ACETIC ACIDS ANTICHOLINERGIC AGENTS... [Pg.71]

Preparation of the quaternary anticholinergic agent benzilonium bromide (47) is begun by conjugate addition of ethylamine to methylacrylate, giving aminoester 42. Alkylation of 42 with methyl bromo-acetate leads to diester 43, which is transformed into pyrrolidone 44 by Dieckmann cyclization, followed by decarboxylation. Reduction of 44 by lithium aluminum hydride leads to the corresponding amino-alcohol (45). Transesterification of alcohol 45 with methyl benzilate leads to 46. Benzilonium bromide (47) is obtained by alkylation of ester 46 with ethyl bromide. 2... [Pg.72]

Anticholinergic agents play a role in management of ulcers by decreasing the secretion of gastric acid... [Pg.92]

Phenearbamide (60) is a structural analogue of acetylcholine which acts as an anticholinergic agent, possibly by serving as a false agonist. It is made by reacting N,N-diphenylcarbamoyl chloride (59) with 2-mercapto-N,N-diethylethamine. [Pg.97]

A great many quaternary amines are active anticholinergic agents. One such parasympathetic blocking... [Pg.307]

Ranitidine (Zantac 75) Antihistaminic—anticholinergic agents Cyclizine (Marezine)... [Pg.311]

Adverse reactions that may be apparent with the use of the antihistaminic-anticholinergic agents primarily include drowsiness or confusion, blurred vision, dry mouth, urinary retention, and possibly tachycardia, particularly in elderly patients. [Pg.313]

Agents that decrease acetylcholine activity can alleviate depressive symptoms (i.e, anticholinergic agents). [Pg.771]

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