Scopolamine hydrobromide

In a one-liter separatory funnel, 94 g (0.215 mol) of scopolamine hydrobromide trihydrate was dissolved in 250 ml of water, made alkaline by shaking with 40 g (1 mol) of sodium hydroxide in 150 ml of water, and the free base immediately extracted with ether. As scopolamine is somewhat soluble in water, the aqueous layer was saturated with potassium carbonate and again extracted with ether. The combined ether extracts were dried over anhydrous magnesium sulfate and the ether removed by distillation, leaving 65 g (0.214 mol 100% yield) of nearly colorless oil. Then 100 g (1.05 mols) of cold methyl bromide was added to a chilled, 500-ml pressure flask containing the 65 g of scopolamine, the flask stoppered tightly with a clamp, and allowed to stand at room temperature for 96 hours. [Pg.990]

The salt was recrystallized from 550 ml of alcohol first crop, 70 g, MP 212° to 214°C second crop, 6 g, MP 195° to 200°C. The combined crops were again recrystallized from 500 ml of 3-A alcohol MP 210° to 212°C. The third recrystallization from 600 ml of alcohol yielded 64 g, MP 214° to 216°C, a 75% yield based on scopolamine hydrobromide trihydrate starting material. [Pg.991]

Potential oscillation was measured in the presence of cholinergic agents (acetylcholine chloride, carbamylcholine chloride, carbamyl- d-methylcholine chloride, and acetyl-/6-methylcholine chloride) and anticholinergic agents (tetramethylammonium chloride, tetra-ethylammonium chloride, succinylcholine chloride, hexamethonium chloride, scopolamine hydrobromide, atropine sulfate, homatropine hydrochloride, and tubocurarine chloride)... [Pg.714]

FIG. 18 Chemical structures of (a) acetylcholine chloride, (b) carbamylcholine chloride, (c) carba-myl-y8-methylcholine chloride, (d) acetyl-/i-methylcholine chloride, (e) tetramethylammonium chloride, (f) tetraethylamonium chloride, (g) succinylcholine chloride, (h) hexamethonium chloride, (i) scopolamine hydrobromide, 0 atropine sulfate, (k) homatropine hydrochloride, and (1) tubocurar-ine chloride. [Pg.716]

Contac 12-hour capsules Phenylpropanolamine hydrochloride, chlorpheniramine maleate, atropine sulfate, scopolamine hydrobromide, hyoscyamine sulfate SmithKline Consumer Products... [Pg.508]

Drug solutions and implantation of osmotic mini-pumps Physostigmine hemisulphate and procyclidine hydrochlorid were obtained from Sigma (St.Louis, U.S.A.), scopolamine hydrobromid from Merck (Darmstadt, Germany), atropine sulphate was obtained from ACF (Amsterdam, The Netherlands), and diazepam from Roche (The Netherlands). HI-6 was made available by the Defence Research Establishment, Suffield, Canada. Soman (O-pinacolyl methylphosphonofluoridate) was synthesised at TNO. Alzet Osmotic Mini-pumps with a constant delivery rate of 0.55 pl/hr (Model 2002, Alza Corp., Palo Alto, USA) were used to deliver PYR, PHY and SCO. The vehicle consisted of 20% propylene glycol, 10% ethanol and 70% water. The pumps were implanted subcutaneously under isoflurane/02 inhalation anesthesia. [Pg.115]

Scopolamine hydrobromide [114-49-8] 3073B I(2)286C, N(2)274D YM4550000, USP... [Pg.1056]

Phenobarbital, Hyoscyamine Sulfate, Atropine Sulfate, and Scopolamine Hydrobromide Elixir... [Pg.168]

Weak bases and their salts (nortriptyline hydrochloride, phenelzine sulfate, chloroquine phosphate, scopolamine hydrobromide, tamoxifen citrate, etc.) approximately 45%... [Pg.404]

Scopolamine hydrobromide trihydrate Methyl bromide Silver nitrate... [Pg.2264]

Joscina hydrobromide Oscine hydrobromide Scopolamine hydrobromide Skopolamin hydrobromide... [Pg.3014]

Scopolamin Hydrobromide Inj. Hospira Healthcare Corporation Canada "... [Pg.3014]

See also in sourсe #XX -- [ Pg.19 ]

See also in sourсe #XX -- [ Pg.114 ]

See also in sourсe #XX -- [ Pg.19 , Pg.477 ]

See also in sourсe #XX -- [ Pg.19 ]

See also in sourсe #XX -- [ Pg.19 ]

See also in sourсe #XX -- [ Pg.19 ]

See also in sourсe #XX -- [ Pg.19 ]

See also in sourсe #XX -- [ Pg.19 , Pg.477 ]

See also in sourсe #XX -- [ Pg.110 ]

See also in sourсe #XX -- [ Pg.153 , Pg.154 , Pg.634 ]

See also in sourсe #XX -- [ Pg.203 ]

See also in sourсe #XX -- [ Pg.19 , Pg.477 ]

See also in sourсe #XX -- [ Pg.84 ]

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