Hexamethonium bromide

Chemical Name N,N,N,N, N, N -Hexamethyl-1,6-hexanediaminium bromide Common Name — 

Structural Formula (CH3)3N (CH2)6N (CH3)3-2Br Chemical Abstracts Registry No. 60-26-4 (Hexamethonium) 

Hexamethylene diamine (116 g), sodium carbonate (466 g), and water (800 ml) were heated to 60°C, and dimethyl sulfate (830 g) added with stirring over 1% hours keeping the temperature below 90°C. The reaction mixture was then stirred at 90°C for 2 hours, then cooled to 20°C, acetone (1,200 ml) added and the whole cooled to 0°C. 

The solid formed was removed by filtration and washed with acetone (150 ml). Filtrate and washings were diiuted with water to 4 liters and heated to 60°C under reflux. To this was 

The resultant embonate (530 g) was filtered off, washed twice with a solution of acetone (75 ml) in water (425 ml), and dried at 100°C to give an amorphous yellow powder, MP 290°C to 291 °C (with decomp.). 588 g of the embonate was dissolved in boiling water (4 liters). 

Hydrobromic acid 50% w/w (325 g) diluted with water (2 liters) was added slowly at the boil and the precipitated embonic acid removed by filtering hot and washing twice with hot water (1 liter). The filtrate and washings were evaporated to dryness in a steam pan and the residue recrystallized from ethyl alcohol (1,200 ml), to yield the dibromide (320 g). 

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Hexamethonium bromide Hexocyclium methyl sulfate Ipronidazole Mefruside... 

Succinylcholine chloride, hexamethonium bromide and decamethonium bromide were purchased from Sigma (St. Louis, MO). NPOE (2-nitrophenyloctyl ether)(Fluka) and poly(vinylchloride)(Aldrich)... 

Uncommon IPRs were tested recently. Polymerized acyl monoglydnate surfactant was found to be as effective as sodium dodecylsulfate for the resolution of organic amines [126]. For the analysis of pyridine-based vitamins in infant formnlas, dioc-tylsulfosuccinate produced a unique retention pattern [133], Among bizarre IPRs, tris(hydroxymethyl)aminomethane was used for the determination of cyclamate in foods. It was selected over different ion-pair reagents such as triethylamine and dibu-tylamine, based on sensitivity and time economies [134]. Hexamethonium bromide, a divalent IPR, was used successfully to separate sulfonates and carboxylates [135]. 

Dose. Hexamethonium bromide has been given parenterally in doses of up to 500 mg daily. 

Codeine Hydrochloride Dequalinium Acetate Fluorometholone Hexamethonium Bromide Riboflavine Stilbazium Iodide Mianserin Hydrochloride Tacrine Hydrochloride Diclofenac Sodium Vinblastine Sulphate Cyclizine Hydrochloride Amiloride Hydrochloride Protoveratrine B Meclofenamate Sodium 5-Methyltryptamine Hydrochloride Dicoumarol Mebendazole Pipradrol Hydrochloride Carbenoxolone Flucytosine Phanquone Phenytoin... 

Diquat Dibromide Distigmine Bromide Ethyl Nicotinate Gallamine Triethiodide Hexamethonium Bromide Hydrastinine Mebezonium Iodide Neomycin Noradrenaline Paraquat Dichloride Pentolinium Tartrate Quinuronium Sulphate Streptomycin Tubocurarine Chloride... 

Hexamethone bromide, 654 Hexamethonium bromide, 654 Hexamethonium iodide, 654 Hexamethyldisilazane, 188 Hexamethylenamine, 654... 

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