Botulinum neurotoxin serotype

Schiavo, G., Shone, C.C., Rossetto, O., Alexander, F.C. and Montecucco, C., Botulinum neurotoxin serotype 1 is a zinc endopeptidase specific for VAMP/ synaptobrevin, J. Biol. Chern., 268, 11516-11519, 1993. [Pg.217]

The effect of administering different botulinum neurotoxin serotypes at the same time or within several months of each other is unknown. Excessive neuromuscular weakness may be exacerbated by administration of another botulinum toxin prior to the resolution of the effects of a previously administered botulinum toxin. Aminoglycosides Cautiously perform coadministration of botulinum toxin type A and aminoglycosides or other agents interfering with neuromuscular transmission (eg, curare-like nondepolarizing blockers, lincosamides, polymyxins, quinidine, magnesium sulfate, anticholinesterases, succinylcholine chloride) because the effect of the toxin may be potentiated. [Pg.1345]

Aoki KR (2001) A comparison of the safety margins of botulinum neurotoxin serotypes A, B, and F in mice. Toxicon 39 1815-20... [Pg.157]

Breidenbach MA, Brunger AT (2004) Substrate recognition strategy for botulinum neurotoxin serotype A. Nature 432 925-9... [Pg.158]

Chen F, Kuziemko GM, Amersdorfer P, Wong C, Marks JD et al. (1997) Antibody mapping to domains of botulinum neurotoxin serotype A in the complexed and uncomplexed forms. Infect Immun 65 1626-30... [Pg.159]

Chen S, Barbieri JT (2006) Unique substrate recognition by botulinum neurotoxins serotypes A and E. J Biol Chem 281 10906-11... [Pg.159]

Chen S, Kim JP, Barbieri JT (2007) Mechanism of substrate recognition by botulinum neurotoxin serotype A. J Biol Chem 282 9621-27... [Pg.159]

Eleopra R, Tugnoli V, Rossetto O, De Grandis D, Montecucco C (1998b) Different time courses of recovery after poisoning with botulinum neurotoxin serotypes A and E in humans. Neurosci Lett 256 135-8... [Pg.160]

Eleopra R, Tugnoli V, Quatrale R, Gastaldo E, Rossetto O et al. (2002) Botulinum neurotoxin serotypes A and C do not affect motor units survival in humans an electrophysiological study by motor units counting. Clin Neurophysiol 113 1258-64 Eleopra R, Tugnoli V, Quatrale R, Rossetto O, Montecucco C (2004) Different types of botulinum toxin in humans. Mov Disord 19 Suppl 8 S53-9... [Pg.160]

Smith TJ, Lou J, Geren IN, Forsyth CM, Tsai R et al. (2005) Sequence variation within botulinum neurotoxin serotypes impacts antibody binding and neutralization. Infect Immun 73 5450-7 Son YJ, Thompson WJ (1995) Schwann cell processes guide regeneration of peripheral axons. Neuron 14 125-32... [Pg.168]

Schiavo, G., Rossetto, O., Catsicas, S., Polverino de Laureto, P., DasGupta, B.R., Benfenati, F., Montecucco, C. (1993a). Identification of the nerve terminal targets of botulinum neurotoxin serotypes A, D, and E. J. Biol. Chem. 268 23784-7. [Pg.431]

Schiavo G, Poulain B, Rossetto O, Benfenati F, Tauc L, Montecucco C (1992 b) Tetanus toxin is a zinc protein and its inhibition of neurotrasmitter release and protease activity depend on zinc. In EMBOJ. 11 3577-83 Schiavo G, Rossetto O, Santucci A, DasGupta BR, Montecucco C (1992 c) Botulinum neurotoxins are zinc proteins. In J. Biol. Chem. 267 23479-83 Schiavo G, Rossetto O, Catsicas S, Polverino de Laureto P, DasGupta BR, Benfenati F, Montecucco C (1993 a) Identification of the nerve-terminal targets of botulinum neurotoxins serotypes A, D and E. In J. Biol. Chem. 268 23784-7 Schiavo G, Santucci A, DasGupta BR, Metha PP, Jontes J, Benfenati F, Wilson MC, Montecucco C (1993 b) Botulinum neurotoxins serotypes A and E cleave SNAP-25 at distinct COOH-terminal peptide bonds. In FEBS Lett. 335 99-103 Schiavo G, Shone CC, Rossetto O, Alexandre FCG, Montecucco C (1993 c) Botulinum neurotoxin serotype F is a zinc endopeptidase specific for VAMP/synOp-tobrevin. In J. Biol. Chem. 268 11516-9... [Pg.191]

Schiavo G, Santucci A, DasGupta BR et al. (1993b) Botulinum neurotoxins serotypes A and E cleave SNAP-25 at distinct COOH-terminal peptide bonds. FEBS Lett 335 99-103. [Pg.215]

Agarwal, R., Binz, T., and Swaminathan, S. 2005. Structural analysis of botulinum neurotoxin serotype F light chain implications on substrate binding and inhibitor design. Biochemistry 44 11758-11765. [Pg.414]

Charles, P.D. 2004. Botulinum neurotoxin serotype A a clinical update on non-cosmetic uses. Am. J. Health Syst. Pharm. 61 S11-S23. [Pg.415]

Merino, L, Thompson, J.D., Millard, C.B., Schmidt, J.J., and Pang, Y.P. 2006. Bis-imidazoles as molecular probes for peripheral sites of the zinc endopeptidase of botulinum neurotoxin serotype A. Bioorg. Med. Chem. 14 3583-3591. [Pg.418]

Schmidt, J.J. and Stafford, R.G. 2005. Botulinum neurotoxin serotype F identification of substrate recognition requirements and development of inhibitors with low nanomolar affinity. Biochemistry 44 4067 073. [Pg.420]

Botulism, a neuroparalytic life-threatening disease, is caused by the botulinum neurotoxin serotype A (BoNTA). Although antibodies are effective in preventing the extracellular toxin to continue the intoxication process, they have no effect on prior intoxicated neurons. Targeting the BoNTA endopeptidase (BoNTAe) could be a valid alternative, since its inhibition may potentially neutralize the intracellular BoNTA. [Pg.255]

Purcell, A. L. and Hoard-Fruchey, H. M. A capillary electrophoresis method to assay catalytic activity of botulinum neurotoxin serotypes Implications for substrate specificity, Anal. Biochem., 366, 207, 2007. [Pg.73]

Schiavo, G., Santucci, A., DasGupta, B. R., Mehta, P. R, Jontes, J., Benfenati, F.. Wilson, M. C. and Montecucco, C., 1993c, Botulinum neurotoxins serotypes A and E cleave SNAP-25 at distinct COOH-terminal peptide bonds. FEES Lett. 335 99-103. [Pg.83]

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