Metocurine iodide

Methohexital (1 mg/kg in 1% solution given at a rate of 1 mL/5 seconds) is used for induction of anesthesia lasting 5 to 7 minutes. Maintenance of anesthesia may be accomplished by intermittent injections of 1% solution or by continuous IV drip of a 0.2% solution. Intermittent injections of about 20 to 40 mg (2 to 4 ml of a 1% solution) may be given as required, usually every 4 to 7 minutes. For continuous drip, the average rate of administration is about 3 mL of a 0.2% solution/min (1 drop/second). Methohexital should not be mixed in the same syringe or administered simultaneously during IV infusion through the same needle with acid solutions, such as atropine sulfate, metocurine iodide, and succinylcholine chloride. 

Examples iTubocurarine chloride Metocurine iodide Gallamine triethiodide Pancuronium bromide Hexafluoronium bromide Fazadinium bromide Alcuronium chloride Dacuronium bromide and Stercuronium iodide. 

Metocurine iodide may be prepared by the treatment of fi -tubocurarine with methyl iodide to effeet methylation, followed by reaction with bimolar coneentration of hydroiodic acid to form the offieial eompound. 

Reaction of d-tubocurarine virith methyl iodide affords metocurine iodide (see above), in virhich the tviro phenolic hydroxyl groups of d-tubocurarine are changed to the methyl ethers and the tertiary amine becomes quaternary. This agent is approximately fourfold more potent than d-tubocurarine in neuromuscular blocking activity. Like d-tubocurarine, it has a long duration of action and is eliminated (predominantly... 

---