Decamethonium-bromide

C3H< N 75-50-3) see Acetylcholine chloride Betaine hydrate Bethanechol chloride Carbachol Carnitine Cetrimonium bromide Choline chloride Choline hydroxide Decamethonium bromide Hexcarbacholine bromide Miltefosine Prolonium iodide... 

Decamethonium bromide Polydimethyldiallylammonium chloride Phytic acid Ethylenediamine 1,3-diaminopropane A,lV-diethylethanolamine (V-ethyldiethylamine Morpholine, tetraazomacrocycles... 

Blockade of neuromuscular transmission produced by an intravenous dose of d-tubocurarine chloride at 0.3 mg/kg, but not that due to 0.5 mg/kg, was antagonized by intravenous 2-PAM 1 at 5 mg/kg. Edrophonium bromide (intravenously at 0.2 mg/kg) was a more potent antagonist of d-tubocurarlne than this dose of 2-PAM 1. Partial blockades of neuromuscular transmission Induced by intravenous injections of decamethonium bromide at 20 Vg/kg, neostigmine bromide at 1 mg/kg, or succinylcholine chloride at 50 Mg/kg were intensified by Intravenous Injection of 2-PAM 1 at 5 mg/kg, in about the same way in which they were enhanced by intravenous doses of edrophonium bromide at 0.2 mg/kg. Intravenous doses of 2-PAM I at up to 150 mg/kg had no effect on the muscle response to direct stimulation in anesthetized cats. 

Succinylcholine chloride, hexamethonium bromide and decamethonium bromide were purchased from Sigma (St. Louis, MO). NPOE (2-nitrophenyloctyl ether)(Fluka) and poly(vinylchloride)(Aldrich)... 

Figure 3. CZE electropherogram of a standard mixture of eight alkylphosphonates (solute concentration 20mgL ) CEPA (1), PMPA (2), CMPA (3), DMPA (4), EEPA (5), IMPA (6), EMPA (7), and MPA (8). CZE conditions 67cmL, (COcmLj x 50 pm ID V = 30 kV Buffer 5mM sorbic acid, 0.1 mM decamethonium bromide, pH 6 indirect UV detection at 254nm. (Reprinted from J.-P. Mercier, P. Morin, M. Dreux, and A. Tambute, J. Chromatogr., A, 741, 279-285 (1996), reproduced with permission from Elsevier Science)...

Alkylphosphonates CZE 5 mM sorbic acid 0.1 mM decamethonium bromide 6 Indirect UV (254) 448 14... 

Sorbic acid has also been shown to be a suitable probe for the analysis of the alkylphosphonic acids and their monoester derivatives (14). A run buffer consisting of 5 mM sorbic acid and 0.1 mM decamethonium bromide, adjusted to pH 6, was used to separate a mixture of eight alkyl alkylphospho-nates. The use of the EOF modifier decamethonium bromide reduced the EOF at pH 6 to enhance the resolution and gave complete separation of the alkylphosphonic acids and their monoester derivatives (e.g. MPA and IMPA) in less than 15 minutes, as shown in Figure 3. 

Dexchlorpheniramine Maleate 404.0 Dipipanone Hydrochloride 418.3 Decamethonium Bromide... 

Adrenaline Decamethonium Bromide Demecarium Bromide Diminazene... 

Paraquat Dichloride 56 Decamethonium Bromide 85 Tubocurarine Chloride... 

Deca-Durabolin" nandrolone. decamethonium bromide decamethonium iodide. 

Examples Suxamethonium chloride Suxethonium bromide Decamethonium bromide. 

The two onium groups present in decamethonium bromide are situated at a distance of 15 A which incidentally compares very closely to that of suxamethonium chloride. Decamethonium cannot be hydrolysed by chloinesterase and hence exerts a much more prolonged effect. 

Qi) Why decamethonium bromide exerts a much more prolonged effeet. 

Replacing the terminal diamino groups of diaminoalkanes by quaternary ammonium moieties gave rise to more efficient separations [57]. Although a similar resolution was achieved with both types of additives, lower concentrations of quaternary ammonium salts were necessary and shorter migration times were obtained, an indication of effectiveness of these bis-quaternary ammonium compounds. Quaternary ammonium salts such as hexamethonium chloride and bromide and decamethonium bromide (DcBr), having alkyl chains of 6 and 10 carbon atoms, respectively, have been used for the separation of the isoforms of OVA and hCG [57], and Tf [55]. For quaternary ammonium salts, the longer alkyl chains were shown to be more effective and chloride salts led to shorter analysis time than bromide ones. 

Decamethonium bromide is used in surgery as a muscle relaxant. It acts by preventing the enzyme acetylcholine esterase from destroying acetylcholine (see page 327), a necessary step in the transmission of nerve impulses. Show how decamethonium bromide can be synthesized from a diamine and an alkyl halide. 

The synthesis of zeolite NU-87 was first reported by Casci and Stewart in 1990 [67]. As structure directing agent, bis-quaternary organic compoimds (cf. Fig. 10) were claimed, with decane-l,10-bis-(trimethylammonium)dibromide (decamethonium-bromide, diquat DeBr2) as the preferred template. Typically, Si02/Al203 ratios from 25 to 60 and NaOH/Si02 ratios around 0.3 are applied. A recommended synthesis mixture is prepared from silica sol, sodium aluminate, sodiiun hydroxide, water and the template. In our own experiments for the... 

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