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Subject immature

By all accounts, the hypothesis of formation of DNA+adamantane+amino acid nanoarchitectures is currently immature and amenable to many technical modifications. Advancement in this subject requires a challenging combination of state-of-the-art approaches of organic chemistry, biochemistry, proteomics, and surface science. [Pg.241]

The determinants of F. have been subject to experimentation mostly in field and captive studies of ungulates. These support the expected association between the frequency and occurrence of Flehmen and the seasonality of reproduction. The elicitation of F. can also depend upon the social context presentation of urine or other stimuli alone may not produce consistent displays. When conspecific urine was tested out of context (i.e. no female present) in male Black-tailed deer, there was no discrimination between urine from individual adult males or between urine from estrous/non-estrous females (Altieri, 1980). Correlation of male endocrine status in reindeer (Rangifer tarandus) showed that the elevation of testosterone during rut and the duration of F. elicited by female urine was coincident F. bouts during rat were twice as long following exposure to adult female urine as to that of immature females (Mossing and Damber, 1981). [Pg.166]

Zeibecoglou K, Ying S, Yamada T, et al. Increased mature and immature CCR3 messenger RNA+ eosinophils in bone marrow from patients with atopic asthma compared with atopic and nonatopic control subjects. J Allergy Clin Immunol 1999 103(1 Pt 1) 99-106. [Pg.253]

Adult subjects who ingested soil (particle size less than 250 im) from the Bunker Hill NPL site absorbed 26% of the resulting 250 pg/70 kg body weight lead dose when the soil was ingested in the fasted state and 2.5% when the same soil lead dose was ingested with a meal (Maddaloni et al. 1998). There are no reported measurements of the absorption of soil-bome lead in infants or children. Additional evidence for a lower absorption of soil-bome lead compared to dissolved lead is provided from studies in laboratory animal models. In immature swine that received oral doses of soil from one of four NPL sites (75 or 225 ig Pb/kg body weight), bioavailability of soil-bome lead ranged from 50% to 82% of that of a similar... [Pg.215]

Innovative methodologies for in vivo microdialysis in immature subjects have facilitated research in multiple areas. Clinically driven experimentation on neonatal anoxia, hypoxia, or ischemia indicates that perinatal manipulations of oxygen and blood flow result in acute and chronic disruptions of neurotransmission and transmitter turnover (Chen et al., 1997 Nakajima et al, 1999 Ogasawara et al., 1999). Recently, a role for toxic free radicals in brain damage induced by prenatal infection was also delineated by in vivo microdialysis in rat pups (Cambonie et al, 2000, 2004). More subtle neonatal manipulations, such as maternal separation or periodic neonatal isolation, coupled with subsequent in... [Pg.239]

DFT brings all these people together, and DFT needs all of these people, because it is an immature subject, with much research yet to be done. And yet, it has already proved itself to be highly useful both for the calculation of molecular electronic ground states and for the qualitative description of molecular behavior. It is already competitive with the best conventional methods, and it is particularly promising in the applications of quantum chemistry to problems in molecular biology which are just now beginning. This is in spite of the lack of complete development of DFT itself. In the basic researches in DFT that must go on, tiiere are a multitude of problems to be solved, and several different points of view to find full expression. [Pg.239]

The heart of modern chemistry is the correlation of the properties of substances with the structures of the atoms, molecules, ions, and crystals of which the substances are composed. As chemists have learned more and more concerning the structure of matter and the manner in which the structures of materials determine their properties, the science of chemistry has correspondingly moved steadily from the empiricism of a new and immature discipline toward the deductive character of a well-developed and mature science. For this reason and because of the excellence of Professor Ryschke-witsch s treatment of the subject, we are pleased to present Chemical Bonding and the Geometry of Molecules55 as an important addition to our series Selected Topics in Modern Chemistry. [Pg.122]

Factors that may have contributed to this metabolic acidosis included low birth weight, renal tubular immaturity, and impaired renal function, which may have resulted in systemic accumulation with repetitive dosing. This case stresses the fact that topical medications can cause systemic effects if a sufficient amount of drug is absorbed in a susceptible subject. [Pg.589]

Laboratory experiments showed that the water content of the muscle of small, immature cod subjected to starvation rose (reflecting protein depletion) from 80% to around 86%, beyond which level the fish died. Larger fish, however, which had spawned several times, could be depleted until the water content of the musculature was over 95% - a remarkable adaptation to the more severe depletion imposed under natural conditions (Love, unpublished). While this phenomenon differs from that described above in fatty fish, it again illustrates a change in the metabolism of fish in response to growth. Likewise, Borisov and Shatunovsky (1973) studied the possibility of using the water content to estimate the natural mortality rate of Barents Sea cod. [Pg.211]

Aging. The biochemistry of senescence is a very immature subject at this time. The majority of the changes that occur are not known, including the reason for the time clocks, but some advances have been made (59). Intimately related to the aging process are the related processes of disease. [Pg.43]

The retroviruses have been the subject of intense study because of the emergence of human immunodeficiency virus (HIV) and acquired immunodeficiency syndrome (AIDS), and this study has led to a structural understanding of complicated viruses that has been unfolding rapidly. In the immature virus, two copies of (+)ssRNA are surrounded by a spherical immature capsid that contains about 2000 copies of the Gag polyprotein (the precursor of the structural proteins), and up to a few hundred copies of larger polyproteins, the most ubiquitous being Gag-Pol, a polyprotein that in addition contains precursors of the proteinase (PR), reverse... [Pg.179]

Thymocytes produced in the bone marrow do not express the T-cellreceptor complex, CD4, or CDS. On relocation to the thymus and rearrangement of the T-cell-receptor genes, the immature thymocyte expresses all of these molecules. These cells are first subjected to positive selection (Figure 33.40). Cells for which the T-cell receptor can bind with reasonable affinity to either class I or class II MHC molecules survive this selection those for which the T-cell receptor does not participate in such an interaction undergo apoptosis and die. The affinities of interaction required to pass this selection are relatively modest, and so contacts between the T-cell receptor and the MHC molecules themselves are sufficient without any significant contribution from the bound peptides (which will be derived from proteins in the thymus). The role of the positive selection step is to prevent the production ofT cells that will not bind to any MHC complex present, regardless of the peptide bound. [Pg.1385]

The development of parallel-plate perfusion chambers [67,68] made possible the study of platelet interaction with the extracellular matrix (ECM) generated by cells in culture or with isolated subendothelial components under defined experimental conditions. The use of the ECM produced by human umbilical vein endothelial cells (HUVEC) in culture as adhesive substrate has Su tated the understanding of the mechanisms involved in primary hemostasis [68]. HUVECs are immature and not subjected to flow conditions during their culture, two Ikctors which may influence the reactivity of their ECM towards platelets [69]. Interestingly, the properties and reactivity of the underlying ECM can be modified by exposure of HUVECs to different stimuli, an experimental approach which has fevored the investigation of basic mechanisms of thrombosis [33]. [Pg.350]

Some vegetables are subject to chilling injury at refrigeration temperatures. This includes failure to ripen normally (mature-green tomatoes, immature bananas, and eggplants), susceptibility to decay (sweet potatoes), undesirable increases in sugars (potatoes), as well as an... [Pg.509]

A diametrically different picture exists in the immature heart The chronic hypoxia to which it is subjected, renders it more resistant against ischemia.17,18 Another intriguing aspect in this state is that ischemic preconditioning is not as effective.19,20 However, it has not been adequately clarified if preconditioning does not really exist or if it is difficult to demonstrate additional protection in an intrinsically resistant heart. [Pg.168]

There are many publications on the subject of neps and their detection, for example Furter and Frey, "and on the determination of the degree of maturity of cotton. " Here, only the principle of the so-called rcd/grccn test will be briefly described, since it is easy to carry out in any textile laboratory - and it gives a quick idea of the proportion of immature cotton. It does not correlate well with other tests of maturity.On the other hand, cotton samples which show the same degree of maturity after the usual maturity test with the air-flow method often show subsequent differences in depth of dyeing,thus underlining the importance of this dyeing test. [Pg.180]


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