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Subject alkaloids

Patients receiving monoamine oxidase inhibitors (MAOI) as antidepressant therapy have been especially subject to the hypertensive effects of vasoactive amines (52). These dietary amines have also been impHcated as causative agents ia migraine. Other aaturaHy occurring alkaloids (qv) have been recognized for centuries as possessing neurological stimulant and depressant properties. [Pg.478]

Replacing one carbon atom of naphthalene with an a2omethene linkage creates the isomeric heterocycles 1- and 2-a2anaphthalene. Better known by their trivial names quinoline [91-22-5] (1) and isoquinoline [119-65-3] (2), these compounds have been the subject of extensive investigation since their extraction from coal tar in the nineteenth century. The variety of studies cover fields as diverse as molecular orbital theory and corrosion prevention. There is also a vast patent Hterature. The best assurance of continuing interest is the frequency with which quinoline and isoquinoline stmctures occur in alkaloids (qv) and pharmaceuticals (qv), for example, quinine [130-95-0] and morphine [57-27-2] (see Alkaloids). [Pg.388]

Tobacco and its alkaloids have long ceased to have any therapeutic importance, but their extensive use as insecticides and the demand for nicotine for the manufacture of nicotinic acid have stimulated interest in processes of extraction and methods of estimation. On the latter subject there is a voluminous literature, of which critical resumes have been published by various authors.Recent work on this subject has been specially concerned with (1) the development of miero- and semi-miero-methods suitable for estimating nieotine in tobacco smoke and the distribution of nieotine on sprayed garden produce, in treated soils and in tobaeeo leaves,(2) the study of conditions necessary to ensure satisfactory results in using particular processes, " and (3) methods of separation and estimation of nicotine, nomicotine and anabasine in mixtures of these bases. ) In the United States and in Russia considerable interest is being shown in the cultivation of types of tobacco rich in nicotine, in finding new industrial uses for tobacco and its alkaloids, and in possible by-products from tobacco plants such as citric and malic acids, i " Surveys of information on tobacco alkaloids have been published by Jackson, i Marion and Spath and Kuffner. ... [Pg.36]

The Corydalis and Dicentra species are distinguished by the number and variety of the alkaloids they contain, and separation and isolation of the latter is a difficult problem. General methods have been devised by Gadamer, Ziegenbein and Wagner, < Gadamer, Spath and Mosettig h ) and Manske, ( but most of the workers on these alkaloids have made contributions to this subject. [Pg.284]

Owing to the frequency with which the botanical attribution of ipecacuanha has been changed, and to the considerable number of substitutes which have from time to time appeared, it is difficult to summarise briefly the botanical distribution of the ipecacuanha alkaloids, and readers interested in this subject may be referred to Staub for information and references. Freise states that emetine and the allied bases are to be found in certain Rubiaceous spp. not usually regarded as sources of these alkaloids, and Orazi has stated that the roots of Bourreria... [Pg.395]

As the re-introduction of mixtures of cinchona alkaloids for use in medicine has given rise to some discussion, a list of the principal papers on this subject is given. Several of these provide analyses of locally produced totaquina. Applezweig and Ronzone have described an ion exchange process for the preparation of totaquina. [Pg.420]

The alkaloid has undergone changes in empirical formula, and that now given is provided by Briggs, Newbold and Stace, after a further investigation and a critical review of published work on this subject. [Pg.666]

In a comprehensive review of this subject Schopf (1937) gave a preliminary description of a number of other syntheses of this kind, including that of teloidine, already referred to. Suggestions for other alkaloidal syntheses were also made and the conditions under which such reactions might take place in plants discussed. [Pg.819]

As the alkaloid was extracted with hexane, acetone, and ethanol, subjected to column chromatography, acidified (AcOH) and then neutralized (NaOH), the cationic form was formulated as a hydroxide salt. However, only two OH groups were detectable on H NMR spectroscopy. Only slight differences were found in the UV spectra taken in methanol [kmax (loge) = 218 (4.68), 302 (4.39), 394 (4.08) nm] and methanol+NaOH [T-max (loge) = 228 (4.66), 310 (4.39) nm]. Three tautomeric forms can be formulated which are shown in Scheme 42. Two of them possess the isoquinolium-7-olate moiety. The H NMR data are presented in Table IV. They indeed unambiguously resemble the cationic species 112. [Pg.107]

A concise total synthesis of the indole alkaloid dihydrocorynantheol (101) (Scheme 19), that features two RCM steps and a zirconocene-catalyzed carbo-magnesation [68], is a further example of Martin s interest in applying RCM as a key reaction for the construction of alkaloid frameworks [69]. The first RCM step was applied to bis-allyl amide 96. The resulting intermediate 97 was directly subjected to carbomagnesation and subsequent elimination to deliver 98 in 71% yield from 96. Amide 98 was then transformed into acrylamide 99 in... [Pg.288]

Marine sponges are a source of an array of polycyclic diamine alkaloids of common biogenetic origin. This class of secondary metabolites has been the subject of four previous reviews [4-7]. Therefore, the present review will include literature reports previously not discussed, dealing with the isolation, structure determination, biological activities, and total synthesis of polycycUc diamine alkaloids isolated from marine sponges. This review will not include guanidine alkaloids [8,9] or the manzamine alkaloids [10,11], since these compounds have been recently reviewed elsewhere. Only polycycUc... [Pg.212]

Further members of this class of alkaloids are the araguspongines K (10) and L (11), isolated from the marine sponge Xestospongia exigua collected at Bayadha, on the Saudi Arabian Red Sea coast [16]. After evaporation of the EtOH extract, it was partitioned between hexanes and MeCN. The polar fraction was subjected to a series of chromatographic separations by column chromatography on silica gel. The structures of both alkaloids 10 and... [Pg.215]

The role of reversed micelles in the manufacture of fine chemicals with enzymes also needs to be assessed and analysed. An outstanding example is lipase catalysed interesterification to produce cocoa butter substitute from readily available cheap materials (Luisi, 1985). This example of reversed micelles is sometimes referred to as a colloidal solution of water in organic systems. A number of water insoluble alkaloids, prostanoids, and steroids have been subjected to useful transformations (Martinek et al., 1987). Peptide synthesis has also been conducted. The advantages of two liquid phases are retained to a very great extent the amount of water can be manipulated to gain advantages from an equilibrium viewpoint. [Pg.160]

Cocoa butter is the fat obtained from subjecting chocolate liquor to pressure. Since the alkaloids are sparingly soluble in fat, only trace amounts of theobromine and caffeine in cocoa butter have been reported. The theobromine and caffeine content of four cocoa butter samples averaged 0.008% and 0.038%, respectively.33... [Pg.182]

The tropane alkaloids are a well-recognized group of structurally related natural products. Long before elucidation of the structures, the mydriatic and anesthetic action of several compounds was exploited (6). The very extensive literature covering the pharmacological properties of the tropane alkaloids will be considered only briefly in this chapter. Readers with a deeper interest in the subject are referred to other publications (7-14) and to the references given in Section VII. [Pg.2]

A biomimetic synthesis of benzo[c]phenanthridine alkaloids from a protoberberine via the equivalent of a hypothetical aldehyde enamine intermediate has been developed (130,131). The enamide 230 derived from berberine (15) was subjected to hydroboration-oxidation to give alcohol 231, oxidation of which with pyridinium chlorochromate afforded directly oxyche-lerythrine (232) instead of the expected aldehyde enamide 233. However, the formation of oxychelerythrine can be rationalized in terms of the intermediacy of 233 as shown in Scheme 41. An alternative and more efficient... [Pg.175]

The seco amide alkaloids have been subjected to various transformations, mainly for structure elucidation purposes. When treated with lithium aluminium hydride, arnottianamide (206) was converted to the tertiary amine, deoxyarnottianamide (224), which on methylation with the Rodionow reagent gave deoxy-O-methylarnottianamide (225) (172,175). Arnottianamide (206) could be O-acetylated (174) as well as O-methylated with diazomethane in HMPA (172). Isoarnottianamide (208) was O-methylated to trimethoxy derivative 226, which under Bischler-Napieralski conditions recyclized to the benzophenantridine alkaloid, chelilutine (227) (176) (Scheme 33). [Pg.297]


See other pages where Subject alkaloids is mentioned: [Pg.334]    [Pg.334]    [Pg.429]    [Pg.36]    [Pg.68]    [Pg.222]    [Pg.287]    [Pg.395]    [Pg.451]    [Pg.464]    [Pg.465]    [Pg.557]    [Pg.561]    [Pg.573]    [Pg.662]    [Pg.701]    [Pg.720]    [Pg.808]    [Pg.19]    [Pg.569]    [Pg.71]    [Pg.99]    [Pg.177]    [Pg.214]    [Pg.218]    [Pg.220]    [Pg.223]    [Pg.225]    [Pg.226]    [Pg.17]    [Pg.476]    [Pg.35]    [Pg.116]    [Pg.232]    [Pg.94]   
See also in sourсe #XX -- [ Pg.166 ]

See also in sourсe #XX -- [ Pg.96 , Pg.97 , Pg.99 , Pg.471 , Pg.566 , Pg.640 , Pg.641 ]




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