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Pyrrolizidine alkaloids Subject

Monocrotaline (170) has been the subject of extensive metabolic study with mammalian and microbiological systems. Pyrrolizidine alkaloids such as monocrotaline require metabolic activation to the corresponding pyrrole derivatives or dehydro alkaloids before they are capable of forming covalent bonds with critical macromolecules within the cell. The X-ray structure of dehydromonocrotaline has recently been determined (226), and the ability of dihydroretronicine derived from monocrotaline to react with deoxyguanosine has been demonstrated in vitro (225). [Pg.398]

The chemical behavior and reactions of pyrrolizidine derivatives were investigated for the most part during structural analysis of naturally occurring pyrrolizidine alkaloids and in the course of the syntheses of their degradation fragments there are several publications concerned specially with this subject. Pyrrolizidine derivatives are typical tertiary amines, and consequently their chemical behavior is a combination of the properties of tertiary amines and of those of the substituent functions. However, some peculiarities of the class can be explained only in terms of the configuration of the bicyclic system. [Pg.353]

The opening of activated cyclopropanes with nitrogen nucleophiles has been widely rqiplied to the synthesis of pyrrolizidine and pyrroline alkaloids by Danishefsky this subject has been reviewed. A number of pyrroline armulations have been based on this principle, illustrated in equation (35a). Similar opening can be accomplished with halides, cuprates, and sulfur or selenium nucleophiles. ... [Pg.921]


See other pages where Pyrrolizidine alkaloids Subject is mentioned: [Pg.396]    [Pg.547]    [Pg.65]    [Pg.37]    [Pg.351]    [Pg.365]    [Pg.70]    [Pg.66]    [Pg.4462]    [Pg.213]    [Pg.164]    [Pg.476]    [Pg.171]    [Pg.135]    [Pg.107]    [Pg.111]    [Pg.405]    [Pg.56]   


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Alkaloid pyrrolizidines

Alkaloids pyrrolizidine

Pyrrolizidin

Pyrrolizidine

Subject alkaloids

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