Diamine alkaloids

Polycyclic Diamine Alkaloids from Marine Sponges... 

Marine sponges are a source of an array of polycyclic diamine alkaloids of common biogenetic origin. This class of secondary metabolites has been the subject of four previous reviews [4-7]. Therefore, the present review will include literature reports previously not discussed, dealing with the isolation, structure determination, biological activities, and total synthesis of polycycUc diamine alkaloids isolated from marine sponges. This review will not include guanidine alkaloids [8,9] or the manzamine alkaloids [10,11], since these compounds have been recently reviewed elsewhere. Only polycycUc... 

Berlinck RGS (2007) Polycyclic Diamine Alkaloids from Marine Sponges. 10 211-238 Besson T, Thiery V (2006) Microwave-Assisted Synthesis of Sulfur and Nitrogen-Containing Heterocycles. 1 59-78... 

Macrocyclic diamine alkaloids from marine sponges... 

Scheme 40. A biomimetic approach to the polycyclic diamine alkaloids model studies.

A Tetracyclic Diamine Alkaloid, Halicyclamine A, from the Marine Sponge Haliclona sp. Jaspars, M. Pasupathy, V. and Crews, P. J. Org. Ghent. 1994, 59, 3253. 

This chapter is focused on madangamines, a small group of complex diamine alkaloids Isolated from marine sponges of the order Haplosclerlda, and covers their Isolation, characterization, biogenesis, biological activity, and synthesis. Structurally, madangamines are pentacyclic alkaloids with an unprecedented skeletal type. 

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