Streptococcus pyogenes diseases

The disease is caused by a single micro-organism, and the susceptibility of that organism to antimicrobial agents is predictable, e.g. scarlet fever caused by Streptococcus pyogenes. 

Gray. G.C. et al. Hyperendemic Streptococcus pyogenes Infections Despite Prophylaxis with Penicillin G Benzathine, X, Eng. J. Med., 92 (July 14, 1991). Henderson, B, M. Wilson, and A.J. Lax Cellular Microbiobg)>, Bacteria-Host Interactions m Health and Disease, John Wilev Sons, Inc., New York, NY, 1999. 

Streptococcus pyogenes is a common Gram-positive organism present in the nasopharynx that can cause severe systemic and invasive disease. In necrotizing fasciitis (also known as flesh eating bacteria), this organism (a facultative anaerobe), rapidly advances within ischemic subcutaneous tissues. ... 

Smoot LM, McCormick JK, Smoot JC, Hoe NP, Strickland I, Cole RL, Barbian KD, Earhart CA, Ohlendorf DH, Veasy LG, Hill HR, Leung DYM, Schlievert PM, Musser JM Characterization of two novel pyrogenic toxin superantigens made by an acute rheumatic fever clone of Streptococcus pyogenes associated with multiple disease outbreaks. Infect Immun 2002 70 7095-7104. 

Staphylococcus aureus and Streptococcus pyogenes in Kawasaki disease. Clin Exp Immunol 2006 143 427 134. 

Azithromycin, an azalide macrolide antibiotic (500 mg p.o. as a single dose on day 1, followed by 250 mg daily on days 2 to 5 total accumulation dose is 1.5 g), is indicated in the treatment of acute bacterial exacerbations of chronic obstructive pulmonary disease caused by Haemophilus influenzae, Moraxella (Branhamella) catarrhalis, or Streptococcus pneumoniae mild community-acquired pneumonia caused by H. influenzae or S. pneumoniae uncomplicated skin and skin-structure infections caused by Staphylococcus aureus, Streptococcus pyogenes, or S. agalactiae second-line therapy of pharyngitis or tonsillitis caused by S. pyogenes and in nongonococcal urethritis or cervicitis caused by Chlamydia trachomatis. 

Aristolochic acid I (5) was also reported to exhibit antibacterial action against Staphylococcus aureus, Diphococcus pneumoniae and Streptococcus pyogenes in infected mice at 50 pg/kg ip [415]. When, rats with wounds infected with S. aureus were treated intraperitoneally or orally with aristolochic acid I (5), they recovered much faster than control. In mice with Pneumococci infections were influenced very well by aristolochic acid I (5). Rabits after intravenous application of aristolochic acid I (5) showed an increased antibacterial action of serum. Aristolactam la (64) and aristolochic acid I (5) showed antibacterial activity against Escherichia coli, Pseudomonas aeruginosa, S. faecalis, S. aureus and S. epidermides [191]. Neurological disorders, especially Parkinson s diseases have been treated by the administration of the aristolactam taliscanine (91) to the affected patient [439]. Cepharadione A (107) exhibited antimicrobial activities [440],... 

In January 1893, Dr. William B. Coley began the administration of a heat-sterilized combined culture of Streptococcus pyogenes (the virulent cause of the disease erysipelas) and Serratia marcescens (a mild pathogen involved in eye and urinary infections), His patient was a 16 year old boy with a large inoperable abdominal sarcoma tumor (a sarcoma is a cancerous growth derived from muscle, bone, cartilage, or connective tissue). The boy developed the chills, headache, fever, local redness, and swelling of an erysipelas infection. The tumor shrank by 80% and the patient remained cancer-free for more than 20 years (Hobohm, 2009). 

Infectious disease A 48 year-old female presented with streptococcal toxic shock syndrome Streptococcus pyogenes) and was found to have ingested levamisole-adulterated cocaine [53 ]. 

Streptococcus pyogenes may get into foods from infected handlers since they are carried on airb)orne droplets from the respiratory tract of infected people who may sneeze or cough on food. The disease caus by this bacteria is commonly called strep throat. Other Streptococcal bacteria can get into the food and cause scarlet fever. However, this is uncommon in the United States today. These diseases are characterized by fever, vomiting, and sore throat. To prevent their spread, food should E)e protected from contamination by infected handlers. Once contracted, the disease responds to penicillin and other antibiotics. Occasionally streptococcal infections produ(3e cxjmplications such as rheumatic fever and glomerulonephritis. 

Musser, J.M., Hauser, A.R., Kim, M., Schlievert, P.M., Nelson, K. and Selander, R.K. 1991. Streptococcus pyogenes causing toxic shock-like syndrome and other invasive diseases clonal diversity and pyrogenic exotoxin expression. Proc. Natl Acad. Sci. USA. 88 2668-2672. 

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