Urethritis nongonococcal

When compared with nongonococcal urethritis, the discharge in gonococcal urethritis is generally more profuse and purulent... 

Infection with C. trachomatis has increased dramatically in recent years. Presently, this bacterium is the most common cause of nongonococcal urethritis, accounting for as many as 50% of cases. More than half of men infected with C. trachomatis exhibit symptoms, whereas, approximately 70% to 80% of women are asymptomatic. 

Nongonococcal urethritis/cervicitis caused by Chlamydia trachomatis Single 1 g dose. 

Ofloxacin Oral levofloxacin has improved pharmacokinetics and pharmacodynamics use is limited to urinary tract infections and nongonococcal urethritis and cervicitis... 

Approximately 75% of women and 50% of men have no urogenital symptoms. Chlamydial infections should be suspected in patients who develop nongonococcal urethritis, mucopurulent cervicitis, or pelvic inflammatory disease. Ocular infection commonly occurs by autoinoculation in the infected individual. 

Chlamydia trachomatis is the primary cause of nongonococcal urethritis, followed by Ureaplasma urealyticum. Doxycycline is the tetracycline of choice for the treatment of nongonococcal urethritis because it has activity against both organisms. There are three tetracyclines that are primarily used for the treatment of infections tetracycline, doxycy-... 

B Nongonococcal urethritis is primarily caused by C. trachomatis. Infections caused by C. trachomatis can be treated with tetracyclines, azithromycin, or macrolides. Doxycyline is contraindicated in pregnant women because of the effects on fetal teeth and... 

Burstein GR, Zeiulman JM. Nongonococcal urethritis—a new paradigm. Clin Infect Dis 1999 28 S66-73. 

This chapter is a review of the antimicrobial susceptibilities of the causative organisms and the treatment of the sexually transmitted infections most prevalent in North America and Western Europe, gonorrhea, nongonococcal urethritis, genital herpes virus infections, and trichomoniasis. Because of their relative rarity or because no important advances in therapy have been made in the past decade, syphilis, lymphogranuloma venereum, chancroid, and granuloma inguinale are not considered. 

Azithromycin, an azalide macrolide antibiotic (500 mg p.o. as a single dose on day 1, followed by 250 mg daily on days 2 to 5 total accumulation dose is 1.5 g), is indicated in the treatment of acute bacterial exacerbations of chronic obstructive pulmonary disease caused by Haemophilus influenzae, Moraxella (Branhamella) catarrhalis, or Streptococcus pneumoniae mild community-acquired pneumonia caused by H. influenzae or S. pneumoniae uncomplicated skin and skin-structure infections caused by Staphylococcus aureus, Streptococcus pyogenes, or S. agalactiae second-line therapy of pharyngitis or tonsillitis caused by S. pyogenes and in nongonococcal urethritis or cervicitis caused by Chlamydia trachomatis. 

Oral/IV use for treatment of infections of the respiratory tract, skin and skin structure, and STDs caused by susceptible organisms treatment of pertussis, diphtheria, erythrasima, intestinal amebiasis, conjunctivitis of the newborn, Legionnaires disease, listeriosis, nongonococcal urethritis, pneumonia of infancy, urogenital infections during pregnancy treatment of acute pelvic inflammatory disease, syphilis, uncomplicated urethral, endocervical, or rectal infections in adults prevention of attacks of rheumatic fever prevention of bacterial endocarditis. 

Ofloxacin interferes with microbial DNA synthesis. It is indicated in the treatment of acnte bacterial exacerbations of chronic bronchitis, commnnity acquired pneumonia, uncomplicated skin and skin structure infections, acute uncomplicated urethral and cervical gonorrhea, nongonococcal urethritis, cervicitis, acute pelvic inflammatory disease, uncomplicated cystitis, complicated urinary tract infections (UTI), and prostatitis cdiV eAhy Escherichia coli. Ophthalmic use for treatment of conjunctivitis and corneal ulcer infections caused by susceptible organisms otic use for treatment of otitis externa, chronic suppurative otitis media in patients with perforated tympanic membranes, and acute otitis media in pediatric patients with tympanostomy tubes. 

Nongonococcal urethritis (NGU) is a clinical entity caused by either C. trachomatis or Ureaplasma urealyticum in 35 5% and 15-25% of the cases, respectively, while up to 30% are culture negative. Therapy for NGU has traditionally been 7 days of doxycycline. New studies evaluating the efficacy of azithromycin in men... 

Worm, A. M. (1990). Roxithromycin and erythromycin in chlamydia-negative nongonococcal urethritis. Acta Derm. Venereal. 70, 269-271. 

Lauharanta, J., Saarinen, K., Mustonen, M. T, and Happonen, H. P. (1993). Single-dose oral azithromycin versus seven-day doxycycline in the treatment of nongonococcal urethritis in males. J. Antimicrob. Chemother. 31, 177—183. 

A 22-year-old man with gonorrhea is to be treated with cefixime and will need another drug to provide coverage for possible urethritis due to C trachomatis. Which one of the following drugs is LEAST likely to be effective in nongonococcal urethritis ... 

The physician is also concerned about the possibility of a nongonococcal urethritis in this patient. Such infections are usually eradicated by the administration of a single dose of (A) Azithromycin... 

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